Gene name: NEK2
Protein name: Serine/threonine-protein kinase Nek2
List of molecules and drugs that interact with protein P51955
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P51955_30E | 30E | n/a | 49837371 | CHEMBL1230011 | (3R,4R)-1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-3-ethylpiperidine-4-carboxylic acid | n/a | |
| 2 | P51955_430 | 430 | n/a | 50990892 | n/a | 5-(1H-benzimidazol-1-yl)-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide | n/a | |
| 3 | P51955_4SP | 4SP | DB07126 | 4566 | CHEMBL319467 | O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE | n/a | |
| 4 | P51955_4VQ | 4VQ | n/a | 46926533 | CHEMBL1230337 | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid | n/a | |
| 5 | P51955_5R1 | 5R1 | n/a | 46926532 | CHEMBL1230435 | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methoxybenzoic acid | n/a | |
| 6 | P51955_5Z5 | 5Z5 | DB07180 | 11840911 | n/a | 5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE | n/a | |
| 7 | P51955_7GG | 7GG | n/a | 137348615 | n/a | 6-[(~{Z})-2-(diethylamino)ethenyl]-~{N}-phenyl-7~{H}-purin-2-amine | n/a | |
| 8 | P51955_7GJ | 7GJ | n/a | 122199242 | n/a | 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N},~{N}-dimethyl-benzamide | n/a | |
| 9 | P51955_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 10 | P51955_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 11 | P51955_BX1 | BX1 | n/a | 46926535 | CHEMBL1231522 | 1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid | n/a | |
| 12 | P51955_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 13 | P51955_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 14 | P51955_ED8 | ED8 | n/a | 50990893 | CHEMBL1614933 | 5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-benzimidazol-1-yl}-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide | n/a | |
| 15 | P51955_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 16 | P51955_EQH | EQH | n/a | n/a | n/a | cis-4-[3-amino-6-(3-cyclopropylthiophen-2-yl)pyrazin-2-yl]cyclohexanecarboxylic acid | n/a | |
| 17 | P51955_F9N | F9N | n/a | 134693892 | n/a | 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide | n/a | |
| 18 | P51955_GGY | GGY | n/a | 56947170 | CHEMBL2042135 | 4-(2-AMINO-5-{4-[(DIMETHYLAMINO)METHYL]THIOPHEN-2-YL}PYRIDIN-3-YL)-2-{[(1R,2Z)-4,4,4-TRIFLUORO-1-METHYLBUT-2-EN-1-YL]OXY}BENZAMIDE | n/a | |
| 19 | P51955_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 20 | P51955_JUP | JUP | n/a | 56947168 | CHEMBL2042136 | 4-(2-AMINO-5-{4-[(DIMETHYLAMINO)METHYL]THIOPHEN-2-YL}PYRIDIN-3-YL)-2-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}BENZAMIDE | n/a | |
| 21 | P51955_LCB | LCB | n/a | 137643315 | CHEMBL4090226 | 4-[(6-ethyl-7~{H}-purin-2-yl)amino]benzenesulfonamide | n/a | |
| 22 | P51955_LCQ | LCQ | n/a | 146170572 | CHEMBL4755796 | 2-phenylazanyl-9~{H}-purine-6-carbonitrile | n/a | |
| 23 | P51955_LCW | LCW | n/a | 146672929 | n/a | 2-[4-[(6-ethenyl-9~{H}-purin-2-yl)amino]phenyl]ethanamide | n/a | |
| 24 | P51955_LD5 | LD5 | n/a | 146672930 | n/a | 4-[(6-ethenyl-7~{H}-purin-2-yl)amino]benzenesulfonamide | n/a | |
| 25 | P51955_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 26 | P51955_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 27 | P51955_NU6 | NU6 | n/a | 122199241 | CHEMBL4742985 | 3-[[6-(cyclohexylmethoxy)-9~{H}-purin-2-yl]amino]benzamide | n/a | |
| 28 | P51955_OL2 | OL2 | n/a | 46926529 | CHEMBL1234980 | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-ethoxybenzoic acid | n/a | |
| 29 | P51955_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 30 | P51955_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 31 | P51955_TRS | TRS | DB03754 | 3777159;88088752;152743085; | n/a | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 32 | P51955_VGK | VGK | n/a | 44475959 | n/a | 4-[2-AMINO-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL]BENZOIC ACID | n/a | |
| 33 | P51955_WCX | WCX | n/a | 50990894 | CHEMBL1615277 | 4-{5-[(1-METHYLPIPERIDIN-4-YL)OXY]-1H-BENZIMIDAZOL-1-YL}-2-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}BENZAMIDE | n/a | |
| 34 | P51955_WGZ | WGZ | n/a | 16050925 | CHEMBL1615278 | 5-{6-[(1-METHYLPIPERIDIN-4-YL)OXY]-1H-BENZIMIDAZOL-1-YL}-3-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}THIOPHENE-2-CARBOXAMIDE | n/a | |
| 35 | P51955_WI2 | WI2 | n/a | 46931216 | CHEMBL1236707 | 1-[3-amino-6-(3-methoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid | n/a | |
| 36 | P51955_XK3 | XK3 | n/a | n/a | n/a | 4-[3-AMINO-6-(3-ETHYLTHIOPHEN-2-YL)PYRAZIN-2-YL]CYCLOHEXANE-1-CARBOXYLIC ACID | n/a | |
| 37 | P51955_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 38 | P51955_T3M | T3M | n/a | 46926534 | CHEMBL1236145 | 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]benzoic acid | n/a | |
| 39 | P51955_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |