Gene name: JAK3
Protein name: Tyrosine-protein kinase JAK3
List of molecules and drugs that interact with protein P52333
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P52333_19Q | 19Q | n/a | 44192904 | CHEMBL2325904 | 2-cyclopropyl-N-[(2S)-3-hydroxy-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 2 | P52333_19R | 19R | n/a | 54674990 | CHEMBL2325905 | 2-cyclopropyl-N-[(2R)-3-hydroxy-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 3 | P52333_19S | 19S | n/a | 53385838 | CHEMBL2325909 | 2-cyclopropyl-N-[(2R)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 4 | P52333_1DT | 1DT | n/a | 71737825 | n/a | N-[(1S)-1-cyclopropylethyl]-2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 5 | P52333_1NX | 1NX | n/a | 67008828 | CHEMBL2376436 | 2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1S)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 6 | P52333_37Q | 37Q | n/a | 11152476 | n/a | N-{1-[6-(phenylamino)pyrazin-2-yl]-1H-benzimidazol-6-yl}prop-2-enamide | n/a | |
| 7 | P52333_3C9 | 3C9 | n/a | 59363349 | CHEMBL3335685 | 1-{(3S)-1-[(2-methylpropyl)sulfonyl]piperidin-3-yl}-3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)urea | n/a | |
| 8 | P52333_3QX | 3QX | n/a | 68291752 | CHEMBL3359927 | 4-{[(1R,2S)-2-fluoro-2-methylcyclopentyl]amino}pyrrolo[1,2-b]pyridazine-3-carboxamide | n/a | |
| 9 | P52333_4LH | 4LH | n/a | 92042864 | CHEMBL3601223 | N-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | n/a | |
| 10 | P52333_4ST | 4ST | n/a | 4369398 | n/a | 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE | n/a | |
| 11 | P52333_79R | 79R | n/a | 122197585 | n/a | (~{Z})-2-cyano-~{N},~{N}-dimethyl-3-[5-[3-[(1~{S},2~{R})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]prop-2-enamide | n/a | |
| 12 | P52333_79S | 79S | n/a | 122197586 | n/a | (2~{S})-2-cyano-~{N},~{N}-dimethyl-3-[5-[3-[(1~{S},2~{R})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]propanamide | n/a | |
| 13 | P52333_79T | 79T | n/a | 137348579 | n/a | 2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-~{N},~{N}-dimethyl-prop-2-enamide | n/a | |
| 14 | P52333_7H4 | 7H4 | n/a | 137348619 | n/a | 1-{(2S,5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one | n/a | |
| 15 | P52333_7KU | 7KU | n/a | 126764334 | n/a | 1-{(3R)-3-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one | n/a | |
| 16 | P52333_7KV | 7KV | n/a | 137348636 | n/a | 1-[(3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one | n/a | |
| 17 | P52333_7KX | 7KX | n/a | 137348637 | n/a | N-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propanamide | n/a | |
| 18 | P52333_933 | 933 | n/a | 54673259 | CHEMBL2325903 | 2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 19 | P52333_934 | 934 | n/a | 162423118 | CHEMBL5084809 | 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone | n/a | |
| 20 | P52333_9J4 | 9J4 | n/a | 117769575 | CHEMBL4096145 | 4-{[(1R,3S)-3-amino-2,2,3-trimethylcyclopentyl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide | n/a | |
| 21 | P52333_9T6 | 9T6 | n/a | n/a | n/a | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | n/a | |
| 22 | P52333_9YV | 9YV | n/a | 131704460 | CHEMBL4096246 | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | n/a | |
| 23 | P52333_9Z4 | 9Z4 | n/a | 137348878 | n/a | 4-({[3-(propanoylamino)phenyl]methyl}amino)pyrrolo[1,2-b]pyridazine-3-carboxamide | n/a | |
| 24 | P52333_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 25 | P52333_DTV | DTV | DB02184 | 446094 | CHEMBL1232392 | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL | n/a | |
| 26 | P52333_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 27 | P52333_F3W | F3W | n/a | 134611726 | CHEMBL4129641 | (~{E})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | n/a | |
| 28 | P52333_F48 | F48 | n/a | 134611728 | CHEMBL4127590 | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | n/a | |
| 29 | P52333_F4B | F4B | n/a | 134611727 | CHEMBL4128266 | (~{E})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | n/a | |
| 30 | P52333_FHX | FHX | DB16133 | 50914062 | CHEMBL4297507 | 3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | inhibitor | |
| 31 | P52333_G4V | G4V | n/a | n/a | n/a | (Z)-1-{2,2-difluoro-6-[5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-4H-1,4-benzoxazin-4-yl}methanimine | n/a | |
| 32 | P52333_G4Y | G4Y | n/a | 137349396 | n/a | N-[(1S)-6-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]imidoformamide | n/a | |
| 33 | P52333_G54 | G54 | n/a | 137349398 | CHEMBL4279720 | [(1S)-1-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | n/a | |
| 34 | P52333_G9B | G9B | n/a | 137349415 | n/a | N-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrazin-2-yl}-1H-benzimidazol-1-yl)phenyl]propanamide | n/a | |
| 35 | P52333_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 36 | P52333_GYW | GYW | n/a | 54766427 | CHEMBL4467503 | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | n/a | |
| 37 | P52333_HB4 | HB4 | n/a | 137349497 | n/a | N-[(1S)-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]imidoformamide | n/a | |
| 38 | P52333_IZA | IZA | DB04716 | 5494425 | CHEMBL21156 | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE | inhibitor | IC50(nM) = 5.0 |
| 39 | P52333_MI1 | MI1 | DB08895 | 9926791 | CHEMBL221959 | 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | inhibitor | |
| 40 | P52333_OV5 | OV5 | n/a | 164885970 | n/a | 6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrrolo[3,4-b]pyridin-4-yl]amino}-N-ethylpyridine-3-carboxamide | n/a | |
| 41 | P52333_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 42 | P52333_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 43 | P52333_PHU | PHU | n/a | 6145 | CHEMBL168445 | 1-phenylurea | n/a | |
| 44 | P52333_PJC | PJC | n/a | 49817363 | CHEMBL1235315 | 3-(1H-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrrole-2,5-dione | n/a | |
| 45 | P52333_RQT | RQT | n/a | 155804528 | n/a | ~{N}-[3-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | n/a | |
| 46 | P52333_RQZ | RQZ | n/a | 155804529 | n/a | 3-[3-(propanoylamino)phenyl]-1~{H}-pyrrolo[2,3-b]pyridine-5-carboxamide | n/a | |
| 47 | P52333_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 48 | P52333_VFC | VFC | n/a | 71285696 | CHEMBL2376147 | N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | n/a | |
| 49 | P52333_Z3A | Z3A | n/a | 68291755 | CHEMBL4447360 | 4-{[(2R,3R)-1,3-dihydroxybutan-2-yl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide | n/a | |
| 50 | P52333_DB06321 | n/a | DB06321 | n/a | n/a | R-348 | n/a | |
| 51 | P52333_RXT | RXT | DB08877 | 25126798 | CHEMBL1789941 | Ruxolitinib | inhibitor | Ki(nM) = 3.2 IC50(nM) = 2.0 Kd(nM) = 2.0 |
| 52 | P52333_3JW | 3JW | DB11817 | 44205240 | CHEMBL2105759 | Baricitinib | inhibitor | |
| 53 | P52333_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 54 | P52333_D7D | D7D | DB14973 | n/a | CHEMBL3655081 | Abrocitinib | inhibitor | |
| 55 | P52333_DB15035 | n/a | DB15035 | n/a | n/a | Zanubrutinib | inhibitor |