Gene name: PLK1
Protein name: Serine/threonine-protein kinase PLK1
List of molecules and drugs that interact with protein P53350
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P53350_071 | 071 | n/a | 24993189 | CHEMBL1094408 | 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | n/a | |
| 2 | P53350_1J3 | 1J3 | n/a | 25253376 | CHEMBL2392544 | 4-{[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino}-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide | n/a | |
| 3 | P53350_1J4 | 1J4 | n/a | 53357478 | CHEMBL2392545 | 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide | n/a | |
| 4 | P53350_1PE | 1PE | n/a | 62551 | CHEMBL1229766 | PENTAETHYLENE GLYCOL | n/a | |
| 5 | P53350_3TA | 3TA | n/a | 46233889 | CHEMBL1945804 | 9-chloro-2-({5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thi one | n/a | |
| 6 | P53350_626 | 626 | DB07186 | 11963557 | n/a | 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE | n/a | |
| 7 | P53350_664 | 664 | n/a | 25210579 | CHEMBL1933582 | 1-METHYL-2-(2-{[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO}PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | n/a | |
| 8 | P53350_79C | 79C | n/a | 25015677 | CHEMBL2392553 | 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | n/a | |
| 9 | P53350_79D | 79D | n/a | 124201651 | CHEMBL4074778 | 4-{[(6R)-7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | n/a | |
| 10 | P53350_8VB | 8VB | n/a | 137348757 | n/a | 2-[[3-[[5-(3-iodanylphenyl)carbonylthiophen-2-yl]carbonylamino]phenyl]methyl]propanedioic acid | n/a | |
| 11 | P53350_8X7 | 8X7 | DB11740 | 24856436 | CHEMBL1976040 | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | n/a | |
| 12 | P53350_8Z5 | 8Z5 | n/a | 2759361 | n/a | Alpha-Bromo-3-Iodotoluene | n/a | |
| 13 | P53350_937 | 937 | DB15110 | 49792852 | CHEMBL1738758 | 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE | inhibitor | |
| 14 | P53350_939 | 939 | n/a | 54759168 | CHEMBL1933576 | 1-METHYL-5-(2-{[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO}PYRIMIDIN-4-YL)-1H-PYRROLE-3-CARBOXAMIDE | n/a | |
| 15 | P53350_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 16 | P53350_ADM | ADM | DB03627 | n/a | n/a | ADAMANTANE | n/a | |
| 17 | P53350_AML | AML | DB02045 | 8060 | n/a | AMYLAMINE | n/a | |
| 18 | P53350_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 19 | P53350_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 20 | P53350_CXS | CXS | DB02219 | 70815;12546061; | n/a | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID | n/a | |
| 21 | P53350_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 22 | P53350_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 23 | P53350_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 24 | P53350_IBI | IBI | DB12062 | n/a | CHEMBL1233528 | N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide | inhibitor | |
| 25 | P53350_IMW | IMW | DB16447 | 10281 | CHEMBL1672002 | 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione | n/a | |
| 26 | P53350_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 27 | P53350_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 28 | P53350_PG0 | PG0 | n/a | 8134 | CHEMBL1235250 | 2-(2-METHOXYETHOXY)ETHANOL | n/a | |
| 29 | P53350_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 30 | P53350_PXE | PXE | n/a | n/a | n/a | 2-methyl-5-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione 1-oxime | n/a | |
| 31 | P53350_R78 | R78 | DB16107 | 11364421 | CHEMBL513909 | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | inhibitor | |
| 32 | P53350_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 33 | P53350_TAR | TAR | DB01694 | 439655 | CHEMBL1200861 | D(-)-TARTARIC ACID | n/a | |
| 34 | P53350_TLA | TLA | DB09459 | 444305 | CHEMBL1236315 | L(+)-TARTARIC ACID | n/a | |
| 35 | P53350_VIH | VIH | n/a | 168451714 | n/a | 7-chloro-4-(cyclopropylmethyl)-1-thioxo-2,4-dihydrothieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one | n/a | |
| 36 | P53350_Z24 | Z24 | n/a | 132275015 | n/a | (3~{R},5~{R})-1-[2,4-bis(fluoranyl)phenyl]-5-oxidanyl-pyrrolidine-3-carboxylic acid | n/a | |
| 37 | P53350_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 38 | P53350_ZOY | ZOY | n/a | 162679640 | n/a | N-[(4S)-4,5-diamino-5-oxopentyl]-10-phenyldecanamide | n/a | |
| 39 | P53350_SRT | SRT | DB14756 | 447315 | CHEMBL225983 | S,R MESO-TARTARIC ACID | n/a | |
| 40 | P53350_1FR | 1FR | DB06897 | 24941248 | CHEMBL490814 | 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol | n/a | IC50(nM) = 99.0 |
| 41 | P53350_2FR | 2FR | DB06963 | 24941249 | n/a | 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide | n/a | |
| 42 | P53350_FRS | FRS | DB07789 | 24875313 | CHEMBL1092830 | 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea | n/a | |
| 43 | P53350_KWT | KWT | DB08059 | 312145 | CHEMBL428496 | Wortmannin | n/a | Ki(nM) = 1500.0 IC50(nM) = 5.8 |
| 44 | P53350_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |