Gene name: MAPK10
Protein name: Mitogen-activated protein kinase
List of molecules and drugs that interact with protein P53779
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P53779_0EI | 0EI | n/a | n/a | n/a | 4-(dimethylamino)-N-[(5Z)-9-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]-11,12-dihydrobenzo[c][1,2]benzodiazocin-2-yl]butanamide | n/a | |
| 2 | P53779_0F0 | 0F0 | n/a | 72200709 | n/a | 3-{[4-(dimethylamino)butanoyl]amino}-N-(4-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide | n/a | |
| 3 | P53779_0G3 | 0G3 | n/a | 137652755 | CHEMBL4092482 | N-[4-[[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-imidazol-4-yl]pyridin-2-yl]amino]phenyl]-3-(propanoylamino)benzamide | n/a | |
| 4 | P53779_1RQ | 1RQ | n/a | 71584212 | CHEMBL2334705 | cyclopropyl[(3R)-3-({4-[6-hydroxy-2-(naphthalen-2-yl)-1H-benzimidazol-1-yl]pyrimidin-2-yl}amino)piperidin-1-yl]methanone | n/a | |
| 5 | P53779_255 | 255 | DB06933 | 16750106 | CHEMBL250409 | N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide | n/a | IC50(nM) = 150.0 |
| 6 | P53779_33A | 33A | DB07010 | 135449325 | CHEMBL220320 | N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE | n/a | Ki(nM) = 550.0 |
| 7 | P53779_34I | 34I | n/a | 46869880 | CHEMBL1682015 | N-[4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | n/a | |
| 8 | P53779_3EL | 3EL | n/a | n/a | n/a | N-{4-[(3-{2-[(trans-4-aminocyclohexyl)amino]pyrimidin-4-yl}pyridin-2-yl)oxy]naphthalen-1-yl}benzenesulfonamide | n/a | |
| 9 | P53779_3H8 | 3H8 | n/a | 87057579 | CHEMBL3355165 | 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide | n/a | |
| 10 | P53779_3HJ | 3HJ | n/a | 87057580 | n/a | N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide | n/a | |
| 11 | P53779_3HN | 3HN | n/a | 87057581 | n/a | 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide | n/a | |
| 12 | P53779_3HQ | 3HQ | n/a | 87057582 | n/a | 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide | n/a | |
| 13 | P53779_3NL | 3NL | n/a | 86278577 | n/a | 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-{1-[(3S)-pyrrolidin-3-yl]-1H-pyrazol-4-yl}benzamide | n/a | |
| 14 | P53779_3WH | 3WH | n/a | 92044057 | n/a | N-ethyl-4-{[4-(1H-indol-3-yl)-5-iodopyrimidin-2-yl]amino}piperidine-1-carboxamide | n/a | |
| 15 | P53779_446 | 446 | n/a | 10153026 | CHEMBL261014 | 4-[(4-{[6-bromo-3-(methoxycarbonyl)-1-oxo-4-phenylisoquinolin-2(1H)-yl]methyl}phenyl)amino]-4-oxobutanoic acid | n/a | |
| 16 | P53779_46C | 46C | n/a | 10195059 | CHEMBL259554 | 4-[(6-chloro-1-oxo-4-phenyl-3-propanoylisoquinolin-2(1H)-yl)methyl]benzoic acid | n/a | |
| 17 | P53779_4F2 | 4F2 | n/a | n/a | CHEMBL3577877 | 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea | n/a | |
| 18 | P53779_519 | 519 | n/a | n/a | CHEMBL3577868 | 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea | n/a | |
| 19 | P53779_537 | 537 | DB01782 | 8515 | CHEMBL7064 | 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE | inhibitor | IC50(nM) = 90.0 Kd(nM) = 22.0 |
| 20 | P53779_589 | 589 | n/a | 50941538 | CHEMBL1644639 | 5-[2-(cyclohexylamino)pyridin-4-yl]-4-naphthalen-2-yl-2-(tetrahydro-2H-pyran-4-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one | n/a | |
| 21 | P53779_738 | 738 | DB07217 | 766948 | CHEMBL234838 | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide | n/a | IC50(nM) = 398.11 |
| 22 | P53779_86C | 86C | n/a | 156155310 | CHEMBL4845770 | 4-[5-(2-chloro-6-fluoroanilino)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-(oxetan-3-yl)thiophene-2-carboxamide | n/a | |
| 23 | P53779_880 | 880 | DB02388 | 447873 | CHEMBL437747 | CYCLOHEXYL-{4-[5-(3,4-DICHLOROPHENYL)-2-PIPERIDIN-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE | n/a | IC50(nM) = 1.6 |
| 24 | P53779_932 | 932 | n/a | 46869741 | CHEMBL1614820 | N-[4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide | n/a | |
| 25 | P53779_984 | 984 | DB03084 | 447872 | CHEMBL252967 | CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE | n/a | IC50(nM) = 1.6 |
| 26 | P53779_9HP | 9HP | DB03623 | n/a | CHEMBL248643 | 9-(4-HYDROXYPHENYL)-2,7-PHENANTHROLINE | inhibitor | IC50(nM) = 590.0 |
| 27 | P53779_ACP | ACP | DB03909 | 91532 | CHEMBL133463 | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | n/a | |
| 28 | P53779_AIZ | AIZ | n/a | 9549178 | CHEMBL1092764 | 3-{6-[(2-CHLOROPHENYL)AMINO]-1H-INDAZOL-3-YL}-5-{[4-(DIMETHYLAMINO)BUTANOYL]AMINO}BENZOIC ACID | n/a | |
| 29 | P53779_AMP | AMP | DB00131 | 6083 | CHEMBL752 | ADENOSINE MONOPHOSPHATE | n/a | |
| 30 | P53779_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 31 | P53779_B9K | B9K | n/a | 134693850 | CHEMBL5194871 | 4-(4-methyl-2-methylsulfanyl-1~{H}-imidazol-5-yl)-~{N}-(4-morpholin-4-ylphenyl)pyridin-2-amine | n/a | |
| 32 | P53779_BGE | BGE | n/a | 134693851 | n/a | 4-(4-methyl-1~{H}-imidazol-5-yl)-~{N}-(4-morpholin-4-ylphenyl)pyridin-2-amine | n/a | |
| 33 | P53779_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | |
| 34 | P53779_BZ9 | BZ9 | n/a | 16733534 | CHEMBL458023 | N-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-1H-benzimidazol-2-amine | n/a | |
| 35 | P53779_C0M | C0M | n/a | 15991561 | CHEMBL232599 | N-{3-CYANO-6-[3-(1-PIPERIDINYL)PROPANOYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDIN-2-YL}1-NAPHTHALENECARBOXAMIDE | n/a | |
| 36 | P53779_C15 | C15 | DB02643 | 84704;101619250; | n/a | N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE | n/a | |
| 37 | P53779_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 38 | P53779_CQQ | CQQ | n/a | 72200707 | n/a | 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide | n/a | |
| 39 | P53779_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 40 | P53779_FMY | FMY | n/a | 25222038 | CHEMBL585951 | N-[(2Z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1H)-ylidene]-4-(3-morpholin-4-yl-1H-1,2,4-triazol-1-yl)aniline | n/a | |
| 41 | P53779_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 42 | P53779_J07 | J07 | DB08005 | 16129582 | CHEMBL248176 | 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide | n/a | IC50(nM) = 57.0 |
| 43 | P53779_J67 | J67 | DB08010 | 45268539 | CHEMBL561540 | (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime | n/a | |
| 44 | P53779_J6F | J6F | n/a | 607855;3097501; | n/a | 7-hexyl-3-methyl-8-sulfanylidene-9H-purine-2,6-dione | n/a | |
| 45 | P53779_J72 | J72 | DB08011 | 46937116 | n/a | (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime | n/a | |
| 46 | P53779_J88 | J88 | DB08015 | 45270264 | CHEMBL549385 | (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime | n/a | |
| 47 | P53779_JBI | JBI | n/a | 11647397 | CHEMBL1946325 | 9-cyclopentyl-N~8~-(2-fluorophenyl)-N~2~-(4-methoxyphenyl)-9H-purine-2,8-diamine | n/a | |
| 48 | P53779_JK1 | JK1 | n/a | 49867175 | CHEMBL1233747 | 3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}-N-(3,4,5-trimethoxyphenyl)benzamide | n/a | |
| 49 | P53779_JK2 | JK2 | n/a | 25174103 | CHEMBL1233748 | 3-{5-[(2-fluorophenyl)amino]-1H-indazol-1-yl}-N-(3,4,5-trimethoxyphenyl)benzamide | n/a | |
| 50 | P53779_JK3 | JK3 | DB08021 | 44224261 | CHEMBL1233749 | 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide | n/a | IC50(nM) = 160.0 |
| 51 | P53779_JNF | JNF | DB08023 | 24801862 | CHEMBL482708 | N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine | n/a | IC50(nM) = 3.0 |
| 52 | P53779_JNK | JNK | DB08025 | n/a | CHEMBL203631 | N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE | n/a | IC50(nM) = 235.0 |
| 53 | P53779_JNO | JNO | DB08026 | 24801863 | CHEMBL485323 | 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide | n/a | IC50(nM) = 270.0 |
| 54 | P53779_KBI | KBI | DB11798 | n/a | CHEMBL1950289 | trans-4-({9-[(3S)-tetrahydrofuran-3-yl]-8-[(2,4,6-trifluorophenyl)amino]-9H-purin-2-yl}amino)cyclohexanol | modulator | |
| 55 | P53779_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 56 | P53779_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 57 | P53779_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 58 | P53779_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 59 | P53779_SNB | SNB | DB08555 | 25203945 | CHEMBL1083185 | 1-(3-BROMOPHENYL)-7-CHLORO-6-METHOXY-3,4-DIHYDROISOQUINOLINE | n/a | IC50(nM) = 398.11 |
| 60 | P53779_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 61 | P53779_TFA | TFA | n/a | 6422;23138861; | CHEMBL506259 | trifluoroacetic acid | n/a | |
| 62 | P53779_UNX | UNX | n/a | |||||
| 63 | P53779_WNK | WNK | n/a | 165411755 | n/a | N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide | n/a | |
| 64 | P53779_X3S | X3S | n/a | 155803725 | CHEMBL4784092 | 4-(4-{[(2-chloro-6-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-5-methyl-N-(oxetan-3-yl)thiophene-2-carboxamide | n/a | |
| 65 | P53779_X3V | X3V | n/a | 155803727 | CHEMBL4753641 | 4-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(oxetan-3-yl)thiophene-2-carboxamide | n/a | |
| 66 | P53779_X3Y | X3Y | n/a | 155803726 | CHEMBL4778645 | 4-(4-{[(2-chloro-6-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(oxetan-3-yl)thiophene-2-carboxamide | n/a | |
| 67 | P53779_SWM | SWM | n/a | 168433033 | CHEMBL5419704 | 2-bromanyl-2,2-bis(fluoranyl)-~{N}-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)ethanamide | n/a | |
| 68 | P53779_SYY | SYY | n/a | 2808202 | CHEMBL1288895 | methyl 3-[(thiophen-2-ylacetyl)amino]thiophene-2-carboxylate | n/a | |
| 69 | P53779_A0P | A0P | DB04395 | 44462678 | n/a | Phosphoaminophosphonic Acid-Adenylate Ester | n/a | |
| 70 | P53779_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |