Gene name: EPHB4
Protein name: Ephrin type-B receptor
List of molecules and drugs that interact with protein P54760
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P54760_1N1 | 1N1 | DB01254 | 3062316 | CHEMBL1421 | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | inhibitor | Kd(nM) = 0.34 |
| 2 | P54760_30K | 30K | n/a | n/a | n/a | (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1H-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2H-indol-2-one | n/a | |
| 3 | P54760_32W | 32W | n/a | 24891645 | CHEMBL2335864 | N-(2-methoxyethyl)-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide | n/a | |
| 4 | P54760_7X1 | 7X1 | DB07249 | 5330197 | CHEMBL169186 | N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | n/a | IC50(nM) = 350.0 |
| 5 | P54760_7X2 | 7X2 | DB07250 | 24836813 | CHEMBL256725 | N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE | n/a | IC50(nM) = 240.0 |
| 6 | P54760_7X3 | 7X3 | DB07251 | 24836812 | CHEMBL403673 | N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE | n/a | IC50(nM) = 16000.0 |
| 7 | P54760_7X4 | 7X4 | DB07252 | 25011728 | CHEMBL257553 | 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide | n/a | IC50(nM) = 40.0 |
| 8 | P54760_7X5 | 7X5 | DB07253 | 25011729 | CHEMBL445162 | N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | n/a | IC50(nM) = 25.0 |
| 9 | P54760_7X6 | 7X6 | DB07254 | 25011730 | CHEMBL496574 | N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE | n/a | IC50(nM) = 741.0 |
| 10 | P54760_7X7 | 7X7 | DB07255 | 25011731 | CHEMBL255874 | N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE | n/a | IC50(nM) = 580.0 |
| 11 | P54760_7X8 | 7X8 | DB07256 | 24861080 | CHEMBL500724 | 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE | n/a | IC50(nM) = 220.0 |
| 12 | P54760_AS6 | AS6 | n/a | 25014684 | CHEMBL1738764 | {4-METHYL-3-[(1-METHYLETHYL)(2-{[3-(METHYLSULFONYL)-5-MORPHOLIN-4-YLPHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENYL}METHANOL | n/a | |
| 13 | P54760_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 14 | P54760_DWT | DWT | n/a | 117602383 | n/a | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 15 | P54760_DXH | DXH | n/a | 16747388 | CHEMBL3752910 | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 16 | P54760_DXK | DXK | n/a | 134693866 | n/a | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 17 | P54760_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 18 | P54760_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 19 | P54760_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 20 | P54760_X9F | X9F | n/a | 15980171 | CHEMBL1236772 | N^4^-1H-INDAZOL-4-YL-N^2^-[3-(METHYLSULFONYL)PHENYL]PYRIMIDINE-2,4-DIAMINE | n/a | |
| 21 | P54760_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 22 | P54760_DB11973 | n/a | DB11973 | n/a | n/a | Tesevatinib | modulator | |
| 23 | P54760_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |