Gene name: NR1H2
Protein name: Oxysterols receptor LXR-beta
List of molecules and drugs that interact with protein P55055
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P55055_0KS | 0KS | n/a | 10112384 | CHEMBL203682 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylbenzenesulfonamide | n/a | |
| 2 | P55055_0KT | 0KT | n/a | 56844264 | n/a | N-methyl-N-(4-{(1S)-2,2,2-trifluoro-1-hydroxy-1-[1-(2-methoxyethyl)-1H-pyrrol-2-yl]ethyl}phenyl)benzenesulfonamide | n/a | |
| 3 | P55055_444 | 444 | DB07080 | 447912 | CHEMBL62136 | N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE | n/a | Ki(nM) = 17.0 IC50(nM) = 9.0 Kd(nM) = 103.0 EC50(nM) = 0.108 |
| 4 | P55055_44B | 44B | DB07082 | 447911 | n/a | 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL | n/a | |
| 5 | P55055_61X | 61X | n/a | 25100472 | CHEMBL593241 | 4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)quinoline | n/a | |
| 6 | P55055_652 | 652 | n/a | 59251511 | CHEMBL3360975 | 2-{2-[2-(2-chlorophenyl)propan-2-yl]-1-[3'-(methylsulfonyl)biphenyl-4-yl]-1H-imidazol-4-yl}propan-2-ol | n/a | |
| 7 | P55055_668 | 668 | n/a | 118987028 | CHEMBL3809850 | 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide | n/a | |
| 8 | P55055_67S | 67S | n/a | 91827457 | CHEMBL3814206 | {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol | n/a | |
| 9 | P55055_6OX | 6OX | n/a | 49787490 | CHEMBL3945199 | 2-[2-[2-[2,6-bis(chloranyl)phenyl]propan-2-yl]-1-[2-fluoranyl-4-[3-fluoranyl-4-(hydroxymethyl)-5-methylsulfonyl-phenyl] phenyl]imidazol-4-yl]propan-2-ol | n/a | |
| 10 | P55055_6Y4 | 6Y4 | n/a | 121596966 | CHEMBL3932169 | [2-[(6~{R})-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-4-(trifluoromethyl)pyrimidin-5-yl]methanol | n/a | |
| 11 | P55055_6Y8 | 6Y8 | n/a | 121596967 | CHEMBL3972392 | (6~{R})-5-(5-fluoranyl-2-methoxy-pyrimidin-4-yl)-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazole | n/a | |
| 12 | P55055_965 | 965 | DB03791 | 447905;72199895; | CHEMBL59030 | [3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid | inhibitor | |
| 13 | P55055_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 14 | P55055_BNS | BNS | DB03848 | 7371;122424353; | CHEMBL1422641 | benzenesulfonic acid | n/a | |
| 15 | P55055_BQ3 | BQ3 | n/a | 22061016 | CHEMBL4522789 | tert-butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate | n/a | |
| 16 | P55055_BU1 | BU1 | DB01955 | 8064 | CHEMBL171623 | 1,4-BUTANEDIOL | n/a | |
| 17 | P55055_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 18 | P55055_CO1 | CO1 | n/a | 3247059 | CHEMBL434302 | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL | n/a | |
| 19 | P55055_D3R | D3R | n/a | 146020554 | CHEMBL4756418 | ~{tert}-butyl (2'~{R},3~{R})-2'-[3-[4-(hydroxymethyl)-3-methylsulfonyl-phenyl]phenyl]-2-oxidanylidene-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate | n/a | |
| 20 | P55055_D40 | D40 | n/a | 146020555 | n/a | ~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-phenyl-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate | n/a | |
| 21 | P55055_D43 | D43 | n/a | 146170530 | n/a | ~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-propan-2-yl-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate | n/a | |
| 22 | P55055_G58 | G58 | n/a | 45100506 | CHEMBL1092952 | N-(2-chloro-6-fluorobenzyl)-1-methyl-N-{[3'-(methylsulfonyl)biphenyl-4-yl]methyl}-1H-imidazole-4-sulfonamide | n/a | |
| 23 | P55055_IPA | IPA | DB02325 | 3776 | CHEMBL582 | ISOPROPYL ALCOHOL | inhibitor | |
| 24 | P55055_KUW | KUW | n/a | 140430661 | n/a | 2-[5-chloranyl-6-[4-[[1,1,3-tris(oxidanylidene)-5-phenyl-2-propan-2-yl-1,2-thiazol-4-yl]amino]piperidin-1-yl]pyridin-3-yl]ethanoic acid | n/a | |
| 25 | P55055_KVB | KVB | n/a | 11627859 | CHEMBL214719 | 2-[4-[[3-[3-(phenylmethyl)-8-(trifluoromethyl)quinolin-4-yl]phenoxy]methyl]phenyl]ethanoic acid | n/a | |
| 26 | P55055_KVK | KVK | n/a | n/a | n/a | 6-[4-[[3-oxidanyl-1,1-bis(oxidanylidene)-5-phenyl-2-propan-2-yl-3~{H}-1,2-thiazol-4-yl]amino]butyl]pyridine-2-sulfonamide | n/a | |
| 27 | P55055_KWE | KWE | n/a | 145707018 | n/a | 3-(4-phenylbutylamino)-1,4-bis(phenylmethyl)pyrrole-2,5-dione | n/a | |
| 28 | P55055_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 29 | P55055_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 30 | P55055_DB03848 | n/a | DB03848 | n/a | n/a | Benzenesulfinic acid | n/a | |
| 31 | P55055_DB11994 | n/a | DB11994 | n/a | n/a | Diacerein | inhibitor | |
| 32 | P55055_RHN | RHN | DB13174 | 10168 | CHEMBL418068 | Rhein | inhibitor |