Gene name: Mapk1
Protein name: Mitogen-activated protein kinase
List of molecules and drugs that interact with protein P63086
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P63086_2H1 | 2H1 | n/a | 73441665 | n/a | 3-[2-(benzyloxy)-8-methylquinolin-6-yl]-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 2 | P63086_38Z | 38Z | n/a | 24866313 | CHEMBL3590107 | (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide | n/a | |
| 3 | P63086_390 | 390 | n/a | 11634725 | CHEMBL583042 | 4-{2-[(2-chloro-4-fluorophenyl)amino]-5-methylpyrimidin-4-yl}-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide | n/a | |
| 4 | P63086_3G7 | 3G7 | n/a | 58985201 | CHEMBL3356117 | (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide | n/a | |
| 5 | P63086_42A | 42A | n/a | 10313195 | CHEMBL4075970 | 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | n/a | |
| 6 | P63086_620 | 620 | n/a | 833835 | CHEMBL1389441 | N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine | n/a | |
| 7 | P63086_6PB | 6PB | n/a | 53338880 | n/a | 6-(3-bromophenyl)-7H-purin-2-amine | n/a | |
| 8 | P63086_6S9 | 6S9 | n/a | 71555247 | CHEMBL2408788 | 1-[3-(2-methylpyridin-4-yl)-1~{H}-pyrazolo[4,3-c]pyridin-6-yl]-3-(phenylmethyl)urea | n/a | |
| 9 | P63086_81Y | 81Y | n/a | 90400979 | CHEMBL4100904 | 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole | n/a | |
| 10 | P63086_A3N | A3N | n/a | 56835775 | CHEMBL2171184 | 5'-deoxy-5'-(prop-2-yn-1-ylamino)adenosine | n/a | |
| 11 | P63086_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 12 | P63086_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 13 | P63086_AOC | AOC | n/a | 22885211 | n/a | 5'-O-prop-2-yn-1-yladenosine | n/a | |
| 14 | P63086_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 15 | P63086_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | |
| 16 | P63086_DF8 | DF8 | n/a | 14408979 | n/a | (2~{R},3~{R},4~{S},5~{R})-2-(6-azanyl-8-diazanyl-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | n/a | |
| 17 | P63086_DJ2 | DJ2 | n/a | 54111948 | n/a | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-(azanyloxymethyl)oxolane-3,4-diol | n/a | |
| 18 | P63086_DKW | DKW | n/a | 3039710 | n/a | (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-prop-2-ynyl-oxolane-2-carboxamide | n/a | |
| 19 | P63086_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 20 | P63086_DQ2 | DQ2 | n/a | 137322690 | n/a | [(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[3-(2-azanylethylamino)-3-oxidanylidene-propyl]sulfanyl-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylimino-azanylidene-azanium | n/a | |
| 21 | P63086_DTW | DTW | n/a | 137322692 | n/a | [(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-(4-diazanyl-4-oxidanylidene-butyl)sulfanyl-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylimino-azanylidene-azanium | n/a | |
| 22 | P63086_DU8 | DU8 | n/a | 138753167 | n/a | 3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(azidomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]sulfanylpropanoic acid | n/a | |
| 23 | P63086_DVZ | DVZ | n/a | 137530087 | n/a | [(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-(2-hydroxy-2-oxoethylsulfanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylimino-azanylidene-azanium | n/a | |
| 24 | P63086_DX4 | DX4 | DB00352 | 1537;2723601; | CHEMBL727 | 2-amino-1,9-dihydro-6H-purine-6-thione | n/a | |
| 25 | P63086_E2K | E2K | n/a | 138753173 | n/a | 4-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(azidomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]sulfanylbutanoic acid | n/a | |
| 26 | P63086_E3K | E3K | n/a | 137530093 | n/a | azanylidene-[[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[2-oxidanylidene-2-(2-sulfanylethylamino)ethyl]sulfanyl-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylimino]azanium | n/a | |
| 27 | P63086_E9W | E9W | n/a | 137551982 | n/a | azanylidene-[[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[2-oxidanylidene-2-(prop-2-ynylamino)ethyl]sulfanyl-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylimino]azanium | n/a | |
| 28 | P63086_F8V | F8V | n/a | 57686268 | CHEMBL4215228 | (3S)-N-[3-(4-fluorophenyl)-1H-indazol-5-yl]-3-(methylsulfanyl)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidine-3-carboxamide | n/a | |
| 29 | P63086_G17 | G17 | n/a | 71598536 | n/a | N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | n/a | |
| 30 | P63086_G67 | G67 | n/a | 58282870 | CHEMBL4213970 | (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide | n/a | |
| 31 | P63086_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 32 | P63086_HMY | HMY | DB07905 | 131676399 | n/a | (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione | n/a | |
| 33 | P63086_KJ4 | KJ4 | n/a | n/a | n/a | N-{3-[(2Z,4S)-1-(2-{[2-(2-amino-1H-imidazol-1-yl)ethyl](methyl)amino}ethyl)-3-(3-cyclohexylpropyl)-2-iminoimidazolidin-4-yl]propyl}guanidine | n/a | |
| 34 | P63086_KJ7 | KJ7 | n/a | 12014150 | n/a | (5S)-5-benzyl-4,5-dihydro-1H-imidazol-2-amine | n/a | |
| 35 | P63086_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 36 | P63086_OLO | OLO | DB02116 | 4592 | CHEMBL280074 | OLOMOUCINE | n/a | IC50(nM) = 27000.0 |
| 37 | P63086_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 38 | P63086_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 39 | P63086_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 40 | P63086_S91 | S91 | DB08513 | 24871491 | n/a | [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID | n/a | |
| 41 | P63086_SB4 | SB4 | DB04338 | 5164 | CHEMBL274064 | 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE | n/a | IC50(nM) = 18000.0 |
| 42 | P63086_SCN | SCN | n/a | 9322 | n/a | THIOCYANATE ION | n/a | |
| 43 | P63086_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 44 | P63086_TT4 | TT4 | n/a | 98510 | n/a | 1-phenyl-1H-1,2,4-triazole-3,5-diamine | n/a | |
| 45 | P63086_Z8B | Z8B | n/a | 86704393 | n/a | 5'-azido-8-bromo-5'-deoxyadenosine | n/a | |
| 46 | P63086_ZAS | ZAS | n/a | 44432644 | CHEMBL232751 | 5'-azido-5'-deoxyadenosine | n/a |