Gene name: ADAM17
Protein name: Disintegrin and metalloproteinase
List of molecules and drugs that interact with protein P78536
# | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
---|---|---|---|---|---|---|---|---|
1 | P78536_002 | 002 | n/a | 5487524 | n/a | N-[(2R)-2-BENZYL-4-(HYDROXYAMINO)-4-OXOBUTANOYL]-L-ISOLEUCYL-L-LEUCINE | n/a | |
2 | P78536_283 | 283 | DB06943 | 9861547 | CHEMBL243024 | (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL | n/a | Ki(nM) = 33.0 |
3 | P78536_403 | 403 | n/a | 11640694 | CHEMBL605764 | (2R,3R)-4-[4-(2-chlorophenyl)piperazin-1-yl]-2,3-dihydroxy-4-oxo-N-(2-thiophen-2-ylethyl)butanamide | n/a | |
4 | P78536_440 | 440 | DB07079 | 23627203 | CHEMBL402747 | 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol | n/a | Ki(nM) = 10.0 |
5 | P78536_4NH | 4NH | DB07121 | 6102708 | CHEMBL202839 | 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE | n/a | IC50(nM) = 67.0 |
6 | P78536_50X | 50X | n/a | 46829300 | CHEMBL1230339 | (2R,3R)-4-[(2R)-2-(3-chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(5-{[2-(trifluoromethyl)-1H-benzimidazol-1-yl]methyl}thiophen-2-yl)methyl]butanamide | n/a | |
7 | P78536_541 | 541 | DB07145 | 6914621 | CHEMBL148169 | (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE | inhibitor | Ki(nM) = 0.06 IC50(nM) = 0.56 |
8 | P78536_550 | 550 | DB07147 | 24800833 | CHEMBL410462 | methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate | n/a | Ki(nM) = 8.0 |
9 | P78536_615 | 615 | n/a | 24978491 | CHEMBL461221 | (1R,2S)-N~2~-hydroxy-1-{4-[(2-phenylquinolin-4-yl)methoxy]benzyl}cyclopropane-1,2-dicarboxamide | n/a | |
10 | P78536_642 | 642 | DB07189 | 25049750 | n/a | (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid | n/a | |
11 | P78536_724 | 724 | n/a | 44631853 | n/a | (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-methylimidazolidine-2,4-dione | n/a | |
12 | P78536_727 | 727 | n/a | 49786962 | n/a | (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-phenylimidazolidine-2,4-dione | n/a | |
13 | P78536_786 | 786 | n/a | 51035425 | CHEMBL1738754 | (2R,3R)-2,3-dihydroxy-4-{(2R)-2-[2-(methylamino)-5-(methylsulfonyl)-1,3-thiazol-4-yl]pyrrolidin-1-yl}-4-oxo-N-{(1R)-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}butanamide | n/a | |
14 | P78536_792 | 792 | DB07233 | 42627769 | CHEMBL527018 | N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan | n/a | IC50(nM) = 140.0 |
15 | P78536_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
16 | P78536_CIT | CIT | DB04272 | 311;19782904;88113319; | CHEMBL1261 | CITRIC ACID | n/a | |
17 | P78536_IH6 | IH6 | DB07964 | 5288615 | CHEMBL207729 | (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE | n/a | IC50(nM) = 8.0 |
18 | P78536_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | |
19 | P78536_INN | INN | n/a | 444587 | n/a | N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide | n/a | |
20 | P78536_IPA | IPA | DB02325 | 3776 | CHEMBL582 | ISOPROPYL ALCOHOL | n/a | |
21 | P78536_KGY | KGY | n/a | 11963536 | CHEMBL234567 | 4-({[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}METHYL)-1-[(3,5-DIMETHYLISOXAZOL-4-YL)SULFONYL]-N-HYDROXYPIPERIDINE-4-CARBOXAMIDE | n/a | |
22 | P78536_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
23 | P78536_Z59 | Z59 | n/a | 44517651 | n/a | (2R,3R)-2,3-dihydroxy-4-oxo-4-[(2R)-2-phenylpyrrolidin-1-yl]-N-(thiophen-2-ylmethyl)butanamide | n/a | |
24 | P78536_Z93 | Z93 | n/a | 49867892 | n/a | 2-{[(4R)-2,5-dioxo-4-(4-pyridin-3-ylphenyl)imidazolidin-4-yl]methyl}-6-methoxy-1-oxo-1H-isoindolium | n/a | |
25 | P78536_Z94 | Z94 | n/a | 44631852 | n/a | N-{4-[(4S)-2,5-dioxoimidazolidin-4-yl]phenyl}acetamide | n/a | |
26 | P78536_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a |