P78536 ADA17_HUMAN
Gene name: ADAM17
Protein name: Disintegrin and metalloproteinase

List of molecules and drugs that interact with protein P78536

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 P78536_002 002 n/a 5487524 n/a N-[(2R)-2-BENZYL-4-(HYDROXYAMINO)-4-OXOBUTANOYL]-L-ISOLEUCYL-L-LEUCINE n/a
2 P78536_283 283 DB06943 9861547 CHEMBL243024 (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL n/a Ki(nM) = 33.0
3 P78536_403 403 n/a 11640694 CHEMBL605764 (2R,3R)-4-[4-(2-chlorophenyl)piperazin-1-yl]-2,3-dihydroxy-4-oxo-N-(2-thiophen-2-ylethyl)butanamide n/a
4 P78536_440 440 DB07079 23627203 CHEMBL402747 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol n/a Ki(nM) = 10.0
5 P78536_4NH 4NH DB07121 6102708 CHEMBL202839 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE n/a IC50(nM) = 67.0
6 P78536_50X 50X n/a 46829300 CHEMBL1230339 (2R,3R)-4-[(2R)-2-(3-chlorophenyl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(5-{[2-(trifluoromethyl)-1H-benzimidazol-1-yl]methyl}thiophen-2-yl)methyl]butanamide n/a
7 P78536_541 541 DB07145 6914621 CHEMBL148169 (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE inhibitor Ki(nM) = 0.06
IC50(nM) = 0.56
8 P78536_550 550 DB07147 24800833 CHEMBL410462 methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate n/a Ki(nM) = 8.0
9 P78536_615 615 n/a 24978491 CHEMBL461221 (1R,2S)-N~2~-hydroxy-1-{4-[(2-phenylquinolin-4-yl)methoxy]benzyl}cyclopropane-1,2-dicarboxamide n/a
10 P78536_642 642 DB07189 25049750 n/a (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid n/a
11 P78536_724 724 n/a 44631853 n/a (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-methylimidazolidine-2,4-dione n/a
12 P78536_727 727 n/a 49786962 n/a (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-phenylimidazolidine-2,4-dione n/a
13 P78536_786 786 n/a 51035425 CHEMBL1738754 (2R,3R)-2,3-dihydroxy-4-{(2R)-2-[2-(methylamino)-5-(methylsulfonyl)-1,3-thiazol-4-yl]pyrrolidin-1-yl}-4-oxo-N-{(1R)-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}butanamide n/a
14 P78536_792 792 DB07233 42627769 CHEMBL527018 N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan n/a IC50(nM) = 140.0
15 P78536_CA CA n/a 271 n/a CALCIUM ION n/a
16 P78536_CIT CIT DB04272 311;19782904;88113319; CHEMBL1261 CITRIC ACID n/a
17 P78536_IH6 IH6 DB07964 5288615 CHEMBL207729 (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE n/a IC50(nM) = 8.0
18 P78536_IMD IMD DB03366 444234;4434133;21983501; n/a IMIDAZOLE n/a
19 P78536_INN INN n/a 444587 n/a N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide n/a
20 P78536_IPA IPA DB02325 3776 CHEMBL582 ISOPROPYL ALCOHOL n/a
21 P78536_KGY KGY n/a 11963536 CHEMBL234567 4-({[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}METHYL)-1-[(3,5-DIMETHYLISOXAZOL-4-YL)SULFONYL]-N-HYDROXYPIPERIDINE-4-CARBOXAMIDE n/a
22 P78536_NA NA n/a 923 n/a SODIUM ION n/a
23 P78536_Z59 Z59 n/a 44517651 n/a (2R,3R)-2,3-dihydroxy-4-oxo-4-[(2R)-2-phenylpyrrolidin-1-yl]-N-(thiophen-2-ylmethyl)butanamide n/a
24 P78536_Z93 Z93 n/a 49867892 n/a 2-{[(4R)-2,5-dioxo-4-(4-pyridin-3-ylphenyl)imidazolidin-4-yl]methyl}-6-methoxy-1-oxo-1H-isoindolium n/a
25 P78536_Z94 Z94 n/a 44631852 n/a N-{4-[(4S)-2,5-dioxoimidazolidin-4-yl]phenyl}acetamide n/a
26 P78536_ZN ZN n/a 32051 CHEMBL1236970 ZINC ION n/a