Gene name: XIAP
Protein name: E3 ubiquitin-protein ligase
List of molecules and drugs that interact with protein P98170
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P98170_0BU | 0BU | n/a | 4466;136775316; | CHEMBL1206126 | 8-({3-[({3-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)amino]benzoyl}amino)naphthalene-1,3,5-trisulfonic acid | n/a | |
| 2 | P98170_0O6 | 0O6 | n/a | 70678411 | CHEMBL2220359 | (3S,6S,7S,9aS,3'S,6'S,7'S,9a'S)-N,N'-(benzene-1,4-diylbis{butane-4,1-diyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethanediyl]})bis[7-(hydroxymethyl)-6-{[(2S)-2-(methylamino)butanoyl]amino}-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide] | n/a | |
| 3 | P98170_15P | 15P | n/a | 16755630 | n/a | POLYETHYLENE GLYCOL (N=34) | n/a | |
| 4 | P98170_1AQ | 1AQ | n/a | 50913339 | CHEMBL2316217 | (3S,7R,8aR)-2-{(2S)-2-(4,4-difluorocyclohexyl)-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxyoctahydropyrrolo[1,2-a]pyrazine-3-carboxamide | n/a | |
| 5 | P98170_1RH | 1RH | n/a | 71819719 | CHEMBL3040508 | N-{(3S)-5-(4-aminobenzoyl)-1-[(2-methoxynaphthalen-1-yl)methyl]-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N~2~-methyl-L-alaninamide | n/a | |
| 6 | P98170_1RK | 1RK | n/a | 71819720 | CHEMBL3040866 | 6-methoxy-5-({(3S)-3-[(N-methyl-L-alanyl)amino]-4-oxo-2',3,3',4,5',6'-hexahydro-5H-spiro[1,5-benzoxazepine-2,4'-pyran]-5-yl}methyl)naphthalene-2-carboxylic acid | n/a | |
| 7 | P98170_2PE | 2PE | n/a | 4867 | n/a | NONAETHYLENE GLYCOL | n/a | |
| 8 | P98170_4WJ | 4WJ | n/a | 52191620 | n/a | 4-(4-bromo-1H-pyrazol-1-yl)piperidinium | n/a | |
| 9 | P98170_4WK | 4WK | n/a | 7019980 | n/a | (2S)-1-{[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino}-1-oxopropan-2-aminium | n/a | |
| 10 | P98170_4XE | 4XE | n/a | 28378486;91826681; | n/a | 4-[2-oxo-2-(piperidin-1-yl)ethyl]piperazin-1-ium | n/a | |
| 11 | P98170_4XF | 4XF | n/a | 91826682 | n/a | (2S)-1-[(6-aminopyridin-2-yl)amino]-1-oxopropan-2-aminium | n/a | |
| 12 | P98170_4YC | 4YC | n/a | 91826689 | n/a | (2R)-4-[2-(6-chloro-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium | n/a | |
| 13 | P98170_4YD | 4YD | n/a | 91826687 | n/a | (2R)-2-methyl-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-ium | n/a | |
| 14 | P98170_4YE | 4YE | n/a | 91826686 | n/a | (2R)-4-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium | n/a | |
| 15 | P98170_4YF | 4YF | n/a | 91826690 | n/a | (2R)-4-[2-(6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium | n/a | |
| 16 | P98170_4YL | 4YL | n/a | 91826692 | n/a | (2R,5R)-4-[2-(6-chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-5-(methoxymethyl)-2-methylpiperazin-1-ium | n/a | |
| 17 | P98170_4YN | 4YN | n/a | 91826691 | n/a | (2R,5R)-4-[2-(6-benzyl-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-5-(methoxymethyl)-2-methylpiperazin-1-ium | n/a | |
| 18 | P98170_7H8 | 7H8 | n/a | 126970794 | n/a | 1-[[(2~{R},5~{R})-1-[2-[3,3-dimethyl-6-(phenylmethyl)-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-oxidanylidene-ethyl]-5-methyl-piperazin-4-ium-2-yl]methyl]pyrrolidin-2-one | n/a | |
| 19 | P98170_7H9 | 7H9 | n/a | 126970793 | n/a | 1-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2~{R},5~{R})-5-methyl-2-[[(3~{R})-3-methylmorpholin-4-yl]methyl]piperazin-4-ium-1-yl]ethanone | n/a | |
| 20 | P98170_7HT | 7HT | n/a | 126970790 | n/a | 1-[3,3-dimethyl-6-(phenylmethyl)-2~{H}-pyrrolo[3,2-c]pyridin-1-yl]-2-[(2~{R},5~{R})-5-methyl-2-[(4-methylpyrazol-1-yl)methyl]piperazin-4-ium-1-yl]ethanone | n/a | |
| 21 | P98170_7HU | 7HU | n/a | 126970791 | n/a | 1-[3,3-dimethyl-6-(phenylmethyl)-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2~{R},5~{R})-2-(methoxymethyl)-5-methyl-piperazin-4-ium-1-yl]ethanone | n/a | |
| 22 | P98170_7J6 | 7J6 | n/a | 126970792 | n/a | 1-[3,3-dimethyl-6-(phenylmethyl)-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2~{R},5~{R})-5-methyl-2-morpholin-4-ylcarbonyl-piperazin-4-ium-1-yl]ethanone | n/a | |
| 23 | P98170_7PE | 7PE | n/a | 526557 | n/a | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL | n/a | |
| 24 | P98170_997 | 997 | DB04612 | 5388929 | CHEMBL1230661 | 1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE | n/a | Kd(nM) = 5.0 |
| 25 | P98170_998 | 998 | DB02628 | 4369343 | CHEMBL1230662 | N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE | n/a | Kd(nM) = 12.0 |
| 26 | P98170_9JZ | 9JZ | n/a | 42609700 | CHEMBL1230673 | (3S)-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-3-methyl-N-(2-pyrimidin-2-ylphenyl)-L-prolinamide | n/a | |
| 27 | P98170_A4E | A4E | n/a | 134611691 | n/a | 1-[6-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2~{R},5~{R})-5-methyl-2-[[(3~{R})-3-methylmorpholin-4-yl]methyl]piperazin-4-ium-1-yl]ethanone | n/a | |
| 28 | P98170_BI6 | BI6 | n/a | 163187301 | n/a | (3S,6S,7Z,10AS)-N-(DIPHENYLMETHYL)-6-{[(2S)-2-(METHYLIDENEAMINO)BUTANOYL]AMINO}-5-OXO-1,2,3,5,6,9,10,10A-OCTAHYDROPYRROLO[1,2-A]AZOCINE-3-CARBOXAMIDE | n/a | |
| 29 | P98170_C3T | C3T | n/a | 134693853 | n/a | (3~{S},6~{S},7~{S},9~{a}~{S})-~{N}-[(4-~{tert}-butylphenyl)methyl]-7-(hydroxymethyl)-6-[[(2~{S})-2-(methylamino)butanoyl]amino]-5-oxidanylidene-1,2,3,6,7,8,9,9~{a}-octahydropyrrolo[1,2-a]azepine-3-carboxamide | n/a | |
| 30 | P98170_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 31 | P98170_CO9 | CO9 | n/a | 15991584;24916924; | CHEMBL393164 | 1-({2-[(1S)-1-AMINOETHYL]-1,3-OXAZOL-4-YL}CARBONYL)-L-PROLYL-L-TRYPTOPHAN | n/a | |
| 32 | P98170_CZ3 | CZ3 | n/a | 6918787 | n/a | 1,1'-{hexa-2,4-diyne-1,6-diylbis[oxy{(2S,3R)-2-[(N-methyl-L-alanyl)amino]-1-oxobutane-3,1-diyl}(2S)pyrrolidine-1,2-diylmethanediyl]}bis[5-(phenylsulfanyl)-1H-tetrazole] | n/a | |
| 33 | P98170_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 34 | P98170_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 35 | P98170_EOH | EOH | DB00898 | 702 | CHEMBL545 | ETHANOL | n/a | |
| 36 | P98170_F2H | F2H | n/a | 138753194 | n/a | 4-[[3-[[3-[(4,8-disulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]phenyl]carbonylamino]naphthalene-1,5-disulfonate | n/a | |
| 37 | P98170_FUE | FUE | n/a | 73673026 | CHEMBL4175992 | 2-[[(2~{R},5~{R})-1-[2-[6-[(4-fluorophenyl)methyl]-3,3-dimethyl-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]-2-oxidanylidene-ethyl]-5-methyl-piperazin-2-yl]methyl]-3~{H}-isoindol-1-one | n/a | |
| 38 | P98170_FUK | FUK | n/a | 73672620 | CHEMBL4170539 | 2-[(2~{R},5~{R})-2-[[(3~{R},5~{R})-3,5-dimethylmorpholin-4-yl]methyl]-5-methyl-piperazin-1-yl]-1-[6-[(~{S})-(4-fluorophenyl)-oxidanyl-methyl]-3,3-dimethyl-2~{H}-pyrrolo[3,2-b]pyridin-1-yl]ethanone | n/a | |
| 39 | P98170_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 40 | P98170_GT6 | GT6 | DB11782 | 49836020 | CHEMBL3039522 | (2S,2'S)-N,N'-[(6,6'-difluoro-1H,1'H-2,2'-biindole-3,3'-diyl)bis{methanediyl[(2R,4S)-4-hydroxypyrrolidine-2,1-diyl][(2S)-1-oxobutane-1,2-diyl]}]bis[2-(methylamino)propanamide] | modulator | |
| 41 | P98170_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 42 | P98170_NI | NI | n/a | 934 | n/a | NICKEL (II) ION | n/a | |
| 43 | P98170_P33 | P33 | DB03394 | 79718 | n/a | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL | n/a | |
| 44 | P98170_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 45 | P98170_SMK | SMK | n/a | 25058143 | CHEMBL574027 | (3S,6S,7R,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-7-(2-aminoethyl)-N-(diphenylmethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide | n/a | |
| 46 | P98170_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 47 | P98170_X22 | X22 | n/a | 25011737 | CHEMBL573550 | (3S,6S,7S,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-N-(diphenylmethyl)-7-(hydroxymethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide | n/a | |
| 48 | P98170_X23 | X23 | n/a | 25011738 | CHEMBL575807 | (3S,6S,7R,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-7-(aminomethyl)-N-(diphenylmethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide | n/a | |
| 49 | P98170_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 50 | P98170_DEQ | DEQ | DB04209 | 2993 | CHEMBL333826 | Dequalinium | antagonist | |
| 51 | P98170_DB12816 | n/a | DB12816 | n/a | n/a | Terpinen-4-ol | downregulator |