Gene name: CDK6
Protein name: Cyclin-dependent kinase 6
List of molecules and drugs that interact with protein Q00534
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q00534_0RS | 0RS | n/a | 49785477 | CHEMBL2089064 | {5-[4-(dimethylamino)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl}[2-(isoquinolin-4-yl)pyridin-4-yl]methanone | n/a | |
| 2 | Q00534_24V | 24V | n/a | 44132585 | CHEMBL3237442 | 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine | n/a | |
| 3 | Q00534_3NU | 3NU | n/a | 49800099 | CHEMBL1230169 | 4-[3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(1-methylpiperidin-4-yl)pyrimidin-2-amine | n/a | |
| 4 | Q00534_3NV | 3NV | n/a | 49800100 | CHEMBL1230170 | 4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine | n/a | |
| 5 | Q00534_4AU | 4AU | n/a | 70689160 | CHEMBL2089060 | 1H-benzimidazol-2-yl(1H-pyrrol-2-yl)methanone | n/a | |
| 6 | Q00534_6ZV | 6ZV | DB12001 | 46220502 | CHEMBL3301610 | N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine | inhibitor | |
| 7 | Q00534_6ZZ | 6ZZ | DB11730 | 44631912 | CHEMBL3545110 | 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | antagonist | |
| 8 | Q00534_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 9 | Q00534_AP9 | AP9 | DB07379 | 6914609 | n/a | (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL | n/a | |
| 10 | Q00534_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 11 | Q00534_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 12 | Q00534_FSE | FSE | DB07795 | 5281614 | CHEMBL31574 | 3,7,3',4'-TETRAHYDROXYFLAVONE | inhibitor | IC50(nM) = 850.0 |
| 13 | Q00534_LQQ | LQQ | DB09073 | 5330286 | CHEMBL189963 | 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | inhibitor | Ki(nM) = 27.0 IC50(nM) = 5.0 |
| 14 | Q00534_N1A | N1A | n/a | 146681117 | CHEMBL4440980 | 5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[(4R)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine | n/a | |
| 15 | Q00534_N1J | N1J | n/a | 138911331 | CHEMBL4545456 | N-[5-(6-ethyl-2,6-diazaspiro[3.3]heptan-2-yl)pyridin-2-yl]-5-fluoro-4-[(4R)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine | n/a | |
| 16 | Q00534_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 17 | Q00534_CPB | CPB | DB03496 | 5287969 | CHEMBL428690 | Alvocidib | n/a | IC50(nM) = 20.0 |
| 18 | Q00534_DB15442 | n/a | DB15442 | n/a | n/a | Trilaciclib | inhibitor |