Q02127 PYRD_HUMAN
Gene name: DHODH
Protein name: Dihydroorotate dehydrogenase (quinone),

List of molecules and drugs that interact with protein Q02127

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 Q02127_03U 03U n/a 54728132 CHEMBL1929435 methyl 4-{[(2Z)-2-cyano-3-hydroxypent-2-enoyl]amino}-4'-fluorobiphenyl-2-carboxylate n/a
2 Q02127_18X 18X n/a 118988340 n/a methyl (2Z)-cyano[3-(3-fluorobiphenyl-4-yl)-4-oxo-1,3-thiazolidin-2-ylidene]acetate n/a
3 Q02127_1EA 1EA n/a 71816353 CHEMBL2385512 6-fluoro-2-[2-methyl-4-phenoxy-5-(propan-2-yl)phenyl]quinoline-4-carboxylic acid n/a
4 Q02127_1KL 1KL n/a 121231465 n/a methyl (2Z)-(3-{4-[(4-tert-butylphenyl)carbamoyl]phenyl}-4-oxo-1,3-thiazolidin-2-ylidene)(cyano)acetate n/a
5 Q02127_1SU 1SU n/a 46209401 CHEMBL3125890 N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide n/a
6 Q02127_1X5 1X5 n/a 44631844 CHEMBL1084928 2-[(cyclopropylcarbonyl)amino]-5-[methyl(pyridin-3-ylmethyl)amino]benzoic acid n/a
7 Q02127_201 201 DB04583 5287459 CHEMBL203836 3-AMIDO-5-BIPHENYL-BENZOIC ACID n/a Ki(nM) = 2800.0
8 Q02127_238 238 n/a 13960674 n/a 6-CHLORO-2-(2'-FLUOROBIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID n/a
9 Q02127_2V6 2V6 n/a 51031042 CHEMBL3289672 N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine n/a
10 Q02127_3FT 3FT n/a 9547914 CHEMBL154493 2-({[3-FLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID n/a
11 Q02127_3RV 3RV n/a 137348167 n/a 5-fluoro-2-{[(5Z)-5-(naphthalen-1-ylmethylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]amino}benzoic acid n/a
12 Q02127_3RY 3RY n/a n/a n/a 2-{[5-(naphthalen-1-ylmethyl)-4-oxo-4H-1lambda~4~,3-thiazol-2-yl]amino}benzoic acid n/a
13 Q02127_3SH 3SH n/a 91995955 CHEMBL3410596 ethyl 2-[(3-chloro-4-methylphenyl)amino]-4-phenyl-1,3-thiazole-5-carboxylate n/a
14 Q02127_3V1 3V1 n/a 92045110 n/a 2-chloro-N-[3-(4-{[(2Z)-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enoyl]amino}phenoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxamide n/a
15 Q02127_3X2 3X2 n/a 129892319 CHEMBL3896992 2-[(E)-{2-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid n/a
16 Q02127_3XS 3XS n/a 129892276 n/a 2-[(E)-{2-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid n/a
17 Q02127_4JG 4JG n/a 118732495 CHEMBL3410576 1-[4-methyl-2-(naphthalen-2-ylamino)-1,3-thiazol-5-yl]ethanone n/a
18 Q02127_4R5 4R5 n/a 118988341 n/a 1-(3,5-difluoro-3'-methoxybiphenyl-4-yl)-3-(1,3-thiazol-5-yl)urea n/a
19 Q02127_52Y 52Y n/a 118796337 n/a methyl (2Z)-cyano[3-(3-fluoro-4'-methoxybiphenyl-4-yl)-4-oxo-1,3-thiazolidin-2-ylidene]acetate n/a
20 Q02127_64B 64B n/a 121232409 CHEMBL4283316 methyl (2Z)-cyano[3-(2-fluoro-4-methoxyphenyl)-4-oxo-1,3-thiazolidin-2-ylidene]acetate n/a
21 Q02127_6X1 6X1 n/a 44631845 CHEMBL1088742 2-{[(3,5-dichlorophenyl)carbamoyl]amino}benzoic acid n/a
22 Q02127_7GF 7GF n/a 137348614 n/a methyl (2Z)-3-azanyl-2-[3-(4-bromophenyl)-4-oxidanylidene-1,3-thiazolidin-2-ylidene]propanoate n/a
23 Q02127_7L7 7L7 n/a 129012054 CHEMBL4290037 methyl (2~{Z})-2-cyano-2-[3-(2-fluorophenyl)-4-oxidanylidene-1,3-thiazolidin-2-ylidene]ethanoate n/a
24 Q02127_7Z5 7Z5 n/a 44631846 CHEMBL1084927 5-[methyl(pyridin-3-ylmethyl)amino]-2-(propanoylamino)benzoic acid n/a
25 Q02127_951 951 n/a 9663654 CHEMBL1088743 2-[(2E)-2-{[5-(2-chlorophenyl)furan-2-yl]methylidene}hydrazino]benzoic acid n/a
26 Q02127_9AU 9AU n/a 54679300 CHEMBL268393 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one n/a
27 Q02127_9BL 9BL n/a 72196240 n/a methyl (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-2,6-dimethylocta-2,6-dienoate n/a
28 Q02127_9BO 9BO n/a 137348800 n/a (2S,3E,7E)-9-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,7-dimethylnona-3,7-dien-2-yl acetate n/a
29 Q02127_9BR 9BR n/a 6445117 n/a 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzaldehyde n/a
30 Q02127_9BU 9BU n/a 57330511 n/a (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethylocta-2,6-dien-1-yl 2-methylpropanoate n/a
31 Q02127_9BX 9BX n/a 137348801 n/a 3-chloro-4,6-dihydroxy-5-[(2Z,6Z,8E)-11-hydroxy-3,7,11-trimethyl-10-oxododeca-2,6,8-trien-1-yl]-2-methylbenzaldehyde n/a
32 Q02127_A26 A26 DB08880 54684141 CHEMBL973 (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide inhibitor
33 Q02127_ACT ACT DB14511 175 n/a ACETATE ION n/a
34 Q02127_ACY ACY DB03166 176;21980959;160748163; CHEMBL539 ACETIC ACID n/a
35 Q02127_AVQ AVQ n/a n/a CHEMBL2177858 2-[(2,5-DICHLOROBENZYL)SULFANYL]-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL n/a
36 Q02127_AYR AYR DB12582 638024 CHEMBL43185 (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one n/a
37 Q02127_B3B B3B n/a 9630277 CHEMBL2178104 2-{(E)-[2-(4-phenyl-1,3-thiazol-2-yl)hydrazinylidene]methyl}benzaldehyde n/a
38 Q02127_B5O B5O n/a 138857393 n/a (6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one n/a
39 Q02127_B5X B5X n/a 138857394 n/a (6R)-1-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one n/a
40 Q02127_B6O B6O n/a 154700496 CHEMBL4647465 3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione n/a
41 Q02127_B6R B6R n/a 154700495 CHEMBL4648164 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione n/a
42 Q02127_B6U B6U n/a 154700494 CHEMBL4635115 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione n/a
43 Q02127_BCE BCE DB07443 54727972 CHEMBL519160 (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide n/a
44 Q02127_BRE BRE DB03480 1543 CHEMBL220467 2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARBOXYLIC ACID n/a IC50(nM) = 7.0
45 Q02127_BVO BVO n/a 145997863 CHEMBL4637493 3-[3,5-bis(fluoranyl)-4-[3-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione n/a
46 Q02127_BVU BVU n/a 145997864 CHEMBL4646288 3-[3,5-bis(fluoranyl)-4-(2-fluorophenyl)phenyl]benzo[f]benzotriazole-4,9-dione n/a
47 Q02127_CE9 CE9 DB06811 656641 CHEMBL1231723 DODECYL NONA ETHYLENE GLYCOL ETHER n/a
48 Q02127_CHW CHW n/a 78225359 n/a 3-chloro-4,6-dihydroxy-5-[(2E,6E,8S)-8-hydroxy-3,7-dimethylnona-2,6-dien-1-yl]-2-methylbenzaldehyde n/a
49 Q02127_CIH CIH DB07559 54727980 CHEMBL484780 (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide n/a
50 Q02127_CJH CJH DB07561 54727985 CHEMBL483995 (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide n/a
51 Q02127_CL CL n/a 312 n/a CHLORIDE ION n/a
52 Q02127_DDQ DDQ DB02613 62452 CHEMBL1232157 DECYLAMINE-N,N-DIMETHYL-N-OXIDE n/a
53 Q02127_DET DET DB07646 4112111 n/a UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE n/a
54 Q02127_DMS DMS DB01093 679 CHEMBL504 DIMETHYL SULFOXIDE n/a
55 Q02127_DOR DOR DB02129 439216 n/a (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID n/a
56 Q02127_DUH DUH n/a 134686803 CHEMBL4173846 2-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide n/a
57 Q02127_EZO EZO n/a 132157920 CHEMBL3980486 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid n/a
58 Q02127_F1W F1W n/a 24772043 CHEMBL595354 4-~{tert}-butyl-~{N}-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide n/a
59 Q02127_F51 F51 n/a 133107895 CHEMBL4227722 2-([1,1'-biphenyl]-4-yl)-3-methyl-1,7-naphthyridine-4-carboxylic acid n/a
60 Q02127_F54 F54 n/a 133107894 CHEMBL4228971 2-[4-(2-chloro-6-methylpyridin-3-yl)phenyl]-6-fluoro-3-methylquinoline-4-carboxylic acid n/a
61 Q02127_FMN FMN DB03247 643976 CHEMBL1201794 FLAVIN MONONUCLEOTIDE n/a
62 Q02127_FNR FNR n/a 445395;101960650;136749967; n/a 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL n/a
63 Q02127_GOL GOL DB09462 753 CHEMBL692 GLYCEROL n/a
64 Q02127_HYT HYT n/a 124220265 CHEMBL4062046 2-methyl-5-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,3-triazole-4-carboxamide n/a
65 Q02127_IEQ IEQ n/a 146269042 CHEMBL5192490 ~{N}-(5-methyl-4-phenoxy-2-propan-2-yl-phenyl)-2-oxidanyl-pyrazolo[1,5-a]pyridine-3-carboxamide n/a
66 Q02127_ILB ILB DB07975 10342449 CHEMBL157105 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID n/a IC50(nM) = 33.0
67 Q02127_ILC ILC DB07976 15942657 CHEMBL371732 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID n/a IC50(nM) = 44.0
68 Q02127_ILF ILF DB07977 15942658 CHEMBL202431 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID n/a IC50(nM) = 2.0
69 Q02127_ILH ILH DB07978 46937112 n/a 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID n/a
70 Q02127_JJE JJE n/a 134470179 CHEMBL5077508 ~{N}-(2-chloranyl-6-fluoranyl-phenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxidanylidene-1,2,4-triazol-1-yl]-5-fluoranyl-2-[(2~{S})-1,1,1-tris(fluoranyl)propan-2-yl]oxy-benzamide n/a
71 Q02127_JS3 JS3 n/a 850573 CHEMBL1432218 2-chloro-4-methyl-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide n/a
72 Q02127_JTS JTS n/a 73330339 n/a 4-methyl-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide n/a
73 Q02127_JTT JTT n/a 26087388 n/a 2,4-dimethyl-N-(naphthalen-2-yl)-1,3-thiazole-5-carboxamide n/a
74 Q02127_JTU JTU n/a 7026732 n/a 6-bromo-2-{4-[(2R)-butan-2-yl]phenyl}-3-methylquinoline-4-carboxylic acid n/a
75 Q02127_KFZ KFZ n/a n/a CHEMBL2177861 2-{[(2,5-DICHLOROPHENYL)METHYL]SULFANYL}-5-ETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL n/a
76 Q02127_LDA LDA DB04147 15433 CHEMBL1233973 LAURYL DIMETHYLAMINE-N-OXIDE n/a
77 Q02127_M0B M0B n/a 118430456 CHEMBL3589752 2-[4-[2,6-bis(fluoranyl)phenoxy]-5-methyl-3-propan-2-yloxy-pyrazol-1-yl]-5-cyclopropyl-3-fluoranyl-pyridine n/a
78 Q02127_M4J M4J n/a 10027278 CHEMBL1650595 N-{4-[5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}glycinamide n/a
79 Q02127_MD7 MD7 DB08169 54723327 CHEMBL142996 (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide n/a
80 Q02127_MDY MDY DB08172 54727975 CHEMBL483161 (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide n/a
81 Q02127_MLJ MLJ n/a 71768304 CHEMBL3184132 ~{N}-[3-oxidanylidene-3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propyl]-4-(trifluoromethyloxy)benzamide n/a
82 Q02127_NA NA n/a 923 n/a SODIUM ION n/a
83 Q02127_ORO ORO DB02262 967;5280334; CHEMBL1235017 OROTIC ACID n/a
84 Q02127_P6G P6G n/a 17472 CHEMBL1235082 HEXAETHYLENE GLYCOL n/a
85 Q02127_PGE PGE DB02327 8172 CHEMBL1235259 TRIETHYLENE GLYCOL n/a
86 Q02127_PO4 PO4 DB14523 1061 n/a PHOSPHATE ION n/a
87 Q02127_R2C R2C n/a 24794393 n/a 5-METHOXY-2-[(4-PHENOXYPHENYL)AMINO]BENZOIC ACID n/a
88 Q02127_R4P R4P n/a 77461001 n/a 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid n/a
89 Q02127_SDV SDV n/a 132472268 n/a N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydroindazol-4-yl]-2,1-benzoxazole-3-carboxamide n/a
90 Q02127_SO4 SO4 DB14546 1117 n/a SULFATE ION n/a
91 Q02127_TMK TMK n/a 154642342 CHEMBL5193821 (6M)-N-(3-chloro-2-methoxy-5-methylpyridin-4-yl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide n/a
92 Q02127_U91 U91 n/a 124220267 CHEMBL4088968 1,5-dimethyl-3-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazole-4-carboxamide n/a
93 Q02127_VGN VGN n/a 46850851 n/a 2-ACETAMIDO-5-(4-PHENYLPHENYL)BENZOIC ACID n/a
94 Q02127_VU7 VU7 n/a 154702659 CHEMBL4744558 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-N-methoxy-3-methylquinoline-4-carboxamide n/a
95 Q02127_W7A W7A n/a 73010357 CHEMBL3990960 2,6-dioxo-5-[2-(4-phenylphenyl)ethyl]-1,2,3,6- tetrahydropyrimidine-4-carboxylic acid n/a
96 Q02127_Y9B Y9B n/a 124220266 CHEMBL4105330 4-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,5-thiadiazole-3-carboxamide n/a
97 Q02127_ZWI ZWI n/a 161111 CHEMBL1213508 3-[decyl(dimethyl)ammonio]propane-1-sulfonate n/a
98 Q02127_T6L T6L n/a 154642261 CHEMBL5180161 (6M)-N-(2-chloro-6-fluorophenyl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide n/a
99 Q02127_T78 T78 n/a 154642303 CHEMBL5193591 (6M)-N-(2-chloro-4-methylpyridin-3-yl)-6-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}pyridine-3-carboxamide n/a
100 Q02127_DB01097 n/a DB01097 n/a n/a Leflunomide inhibitor IC50(nM) = 800.0
101 Q02127_AOQ AOQ DB01117 n/a CHEMBL1450 Atovaquone inhibitor
102 Q02127_BRF BRF DB03523 57030 CHEMBL38434 Brequinar modulator Ki(nM) = 12.0
IC50(nM) = 0.48
103 Q02127_DB04281 n/a DB04281 n/a n/a 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone n/a
104 Q02127_DB06481 n/a DB06481 n/a n/a Manitimus n/a
105 Q02127_J4Z J4Z DB08006 24882195 CHEMBL475814 N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine n/a IC50(nM) = 200000.0
106 Q02127_J5Z J5Z DB08008 25263414 CHEMBL492529 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine n/a IC50(nM) = 30000.0
107 Q02127_N8E N8E DB08249 159866 n/a 3,6,9,12,15-PENTAOXATRICOSAN-1-OL n/a