Gene name: MAP2K1
Protein name: Dual specificity mitogen-activated
List of molecules and drugs that interact with protein Q02750
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q02750_1CX | 1CX | DB06892 | n/a | n/a | (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide | n/a | |
| 2 | Q02750_22T | 22T | n/a | 59229792 | CHEMBL2391620 | 7-chloranyl-6-[(3S)-pyrrolidin-3-yl]oxy-2H-isoquinolin-1-one | n/a | |
| 3 | Q02750_2P7 | 2P7 | n/a | 16223325 | CHEMBL2146887 | [3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-(3-OXIDANYLAZETIDIN-1-YL)METHANONE | n/a | |
| 4 | Q02750_3BM | 3BM | DB07046 | 25163987 | CHEMBL573819 | 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide | n/a | |
| 5 | Q02750_3EW | 3EW | DB11689 | 10127622 | CHEMBL1614701 | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide | inhibitor | |
| 6 | Q02750_3EX | 3EX | n/a | 78333433 | n/a | 3-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)furo[3,2-c]pyridine-2-carboxamide | n/a | |
| 7 | Q02750_3EY | 3EY | n/a | 44137223 | n/a | 8-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-7-carboxamide | n/a | |
| 8 | Q02750_3OR | 3OR | DB12933 | 11548630 | CHEMBL1614766 | 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(3-oxo-1,2-oxazinan-2-yl)methyl]benzamide | n/a | |
| 9 | Q02750_3OS | 3OS | n/a | 11430524 | CHEMBL1684486 | 2-[(4-ethynyl-2-fluorophenyl)amino]-3,4-difluoro-N-(2-hydroxyethoxy)-5-{[(2-hydroxyethoxy)imino]methyl}benzamide | n/a | |
| 10 | Q02750_3V0 | 3V0 | n/a | 24743899 | CHEMBL2087077 | N-{[(2R)-2,3-dihydroxypropyl]oxy}-3-[(2-fluoro-4-iodophenyl)amino]furo[3,2-c]pyridine-2-carboxamide | n/a | |
| 11 | Q02750_4BM | 4BM | DB07101 | 9826528 | CHEMBL507361 | N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide | n/a | IC50(nM) = 0.6 Kd(nM) = 0.4 |
| 12 | Q02750_4W5 | 4W5 | n/a | 1501980 | n/a | ethyl 2H-indazole-5-carboxylate | n/a | |
| 13 | Q02750_573 | 573 | n/a | 46926364 | CHEMBL2087078 | 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide | n/a | |
| 14 | Q02750_5BM | 5BM | DB17060 | 3006531 | CHEMBL34704 | (2Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile | n/a | |
| 15 | Q02750_5EZ | 5EZ | n/a | 73348939 | CHEMBL2391618 | 7-choro-6-[(3R)-pyrrolidin-3-ylmethoxy]isoquinolin-1(2H)-one | n/a | |
| 16 | Q02750_5U5 | 5U5 | n/a | 54577344 | CHEMBL3699142 | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide | n/a | |
| 17 | Q02750_5Y0 | 5Y0 | n/a | 10152076 | CHEMBL507836 | N-[(2S)-2,3-bis(oxidanyl)propoxy]-3,4-bis(fluoranyl)-2-[(2-fluoranyl-4-iodanyl-phenyl)amino]benzamide | n/a | |
| 18 | Q02750_77D | 77D | n/a | 56643086 | CHEMBL1933936 | 2-[(2-fluoro-4-iodophenyl)amino]-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine-3-carboxamide | n/a | |
| 19 | Q02750_80C | 80C | n/a | 162678564 | n/a | 8-(2-chloranyl-4-methoxy-phenyl)-7-fluoranyl-1-piperidin-4-yl-imidazo[4,5-c]quinoline | n/a | |
| 20 | Q02750_92P | 92P | n/a | 21110084 | CHEMBL2391621 | 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID | n/a | |
| 21 | Q02750_ACP | ACP | DB03909 | 91532 | CHEMBL133463 | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | n/a | |
| 22 | Q02750_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 23 | Q02750_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 24 | Q02750_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 25 | Q02750_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 26 | Q02750_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 27 | Q02750_BBM | BBM | DB03115 | 448535 | n/a | 5-BROMO-N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE | n/a | |
| 28 | Q02750_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 29 | Q02750_CHU | CHU | DB15254 | 16719221 | CHEMBL3264002 | N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide | n/a | |
| 30 | Q02750_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 31 | Q02750_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 32 | Q02750_E62 | E62 | n/a | 137349229 | n/a | (3S,4R,8S,9S,11E)-8,9,16-trihydroxy-3,4-dimethyl-14-(methylamino)-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione | n/a | |
| 33 | Q02750_EUI | EUI | DB05239 | 16222096 | CHEMBL2146883 | [3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE | inhibitor | IC50(nM) = 0.9 |
| 34 | Q02750_FZC | FZC | n/a | 166625052 | n/a | (1~{R},3~{S})-3-[[6-[2-chloranyl-4-(4-methylpyrimidin-2-yl)oxy-phenyl]-3-methyl-1~{H}-indazol-4-yl]oxy]cyclohexan-1-amine | n/a | |
| 35 | Q02750_GIK | GIK | n/a | n/a | n/a | ~{N}-[4-[[6-(3-chloranylpyridin-4-yl)-3-methyl-1~{H}-indazol-4-yl]oxy]cyclohexyl]ethanamide | n/a | |
| 36 | Q02750_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 37 | Q02750_IZG | IZG | DB12241 | 24963252 | CHEMBL1615025 | 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione | n/a | |
| 38 | Q02750_KSA | KSA | DB02152 | 3035817 | CHEMBL281948 | K-252A | n/a | |
| 39 | Q02750_LCJ | LCJ | DB11982 | 42642654 | CHEMBL3330650 | 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide | n/a | |
| 40 | Q02750_LSG | LSG | n/a | 24784164 | CHEMBL1169814 | 5-acetyl-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrole-3-carboxamide | n/a | |
| 41 | Q02750_LUG | LUG | DB08130 | 25023709 | CHEMBL485945 | N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine | n/a | |
| 42 | Q02750_M3K | M3K | n/a | 57625005 | CHEMBL2376668 | 2-([3R-3,4-dihydroxybutyl]oxy)-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]benzamide | n/a | |
| 43 | Q02750_MEK | MEK | n/a | 11533791 | CHEMBL464238 | 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(2-hydroxyethoxy)methyl]benzamide | n/a | |
| 44 | Q02750_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 45 | Q02750_MRA | MRA | DB08208 | 10150081 | n/a | 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE | n/a | |
| 46 | Q02750_MT8 | MT8 | n/a | 7438110 | n/a | (1R)-1-hydroxy-1-methyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one | n/a | |
| 47 | Q02750_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 48 | Q02750_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 49 | Q02750_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 50 | Q02750_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 51 | Q02750_QO7 | QO7 | DB11967 | 10288191 | CHEMBL3187723 | 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide | inhibitor | |
| 52 | Q02750_QOA | QOA | DB14904 | 44187362 | CHEMBL2107832 | N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide | inhibitor | |
| 53 | Q02750_QOM | QOM | DB08911 | 11707110 | CHEMBL2103875 | Trametinib | inhibitor | |
| 54 | Q02750_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 55 | Q02750_U9F | U9F | n/a | 168654891 | n/a | {3-[(1M,2M)-2-{[(1S,2P)-1H,1'H-[2,2'-bipyrrol]-5-yl-kappaN~1~]methylidene}-2H-pyrrol-5-yl-kappaN]-N-(2-{2-[3-({(3M)-3-[(4aM)-3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl}amino)-3-oxopropoxy]ethoxy}ethyl)propanamidato}(difluorido)boron | n/a | |
| 56 | Q02750_V04 | V04 | n/a | 44545708 | CHEMBL2087076 | 4-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1H-indazole-5-carboxamide | n/a | |
| 57 | Q02750_VRA | VRA | DB06309 | 44182295 | CHEMBL1236682 | N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide | n/a | |
| 58 | Q02750_YQY | YQY | n/a | 16222191 | CHEMBL2146888 | [3-(AMINOMETHYL)-3-OXIDANYL-AZETIDIN-1-YL]-[3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]METHANONE | n/a | |
| 59 | Q02750_YSO | YSO | n/a | 54016394 | CHEMBL2391619 | 3-AMINO-1H-INDAZOLE-4-CARBONITRILE | n/a | |
| 60 | Q02750_SU5 | SU5 | n/a | 852486 | CHEMBL1550931 | 1~{H}-indol-2-yl(pyridin-3-yl)methanone | n/a | |
| 61 | Q02750_T1K | T1K | n/a | 155804541 | CHEMBL4763766 | 2-[5-[ethyl(methyl)amino]imidazo[1,2-a]pyrimidin-7-yl]phenol | n/a | |
| 62 | Q02750_T3W | T3W | n/a | 155804542 | n/a | 2-(4-iodophenyl)-8~{H}-imidazo[1,2-c]pyrimidin-5-one | n/a | |
| 63 | Q02750_T4N | T4N | n/a | 685785 | n/a | ~{N}-(4-methoxyphenyl)-2-[(2~{S})-3-oxidanylidenethiomorpholin-2-yl]ethanamide | n/a | |
| 64 | Q02750_DB8 | DB8 | DB06616 | 5328940 | CHEMBL288441 | Bosutinib | inhibitor | IC50(nM) = 1.0 Kd(nM) = 19.0 |
| 65 | Q02750_DB08911 | n/a | DB08911 | n/a | n/a | Trametinib | inhibitor |