Gene name: TOP2B
Protein name: DNA topoisomerase 2-beta
List of molecules and drugs that interact with protein Q02880
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q02880_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 2 | Q02880_AKE | AKE | n/a | 2134 | CHEMBL49442 | 1,4-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione | n/a | |
| 3 | Q02880_ALA | ALA | DB00160 | 5950;7311724; | CHEMBL279597 | ALANINE | n/a | |
| 4 | Q02880_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 5 | Q02880_ASW | ASW | DB00276 | 2179 | CHEMBL43 | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide | inhibitor | IC50(nM) = 2760.0 EC50(nM) = 11000.0 |
| 6 | Q02880_EVP | EVP | DB00773 | 36462 | CHEMBL44657 | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | inhibitor | IC50(nM) = 70.0 EC50(nM) = 70000.0 |
| 7 | Q02880_ITH | ITH | n/a | 163321806 | n/a | 4-[(2S,3R)-3-[3,5-bis(oxidanylidene)piperazin-1-ium-1-yl]butan-2-yl]piperazin-4-ium-2,6-dione | n/a | |
| 8 | Q02880_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 9 | Q02880_MIX | MIX | DB01204 | 4212 | CHEMBL58 | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE | modulator | |
| 10 | Q02880_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 11 | Q02880_N2N | N2N | n/a | 137349777 | n/a | dichloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum | n/a | |
| 12 | Q02880_N2R | N2R | n/a | 137349778 | n/a | dichloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum | n/a | |
| 13 | Q02880_N2S | N2S | n/a | 137349779 | n/a | chloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum | n/a | |
| 14 | Q02880_N2W | N2W | n/a | 137349781 | n/a | chloro{4,5-di(amino-kappaN)-N-[9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]pentanamide}platinum | n/a | |
| 15 | Q02880_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 16 | Q02880_DB00380 | n/a | DB00380 | n/a | n/a | Dexrazoxane | inhibitor | |
| 17 | Q02880_DM1 | DM1 | DB00694 | 30323 | CHEMBL178 | Daunorubicin | inhibitor | |
| 18 | Q02880_DM2 | DM2 | DB00997 | 31703 | CHEMBL53463 | Doxorubicin | inhibitor | IC50(nM) = 727.0 |
| 19 | Q02880_A0P | A0P | DB04395 | 44462678 | n/a | Phosphoaminophosphonic Acid-Adenylate Ester | n/a | |
| 20 | Q02880_DB05022 | n/a | DB05022 | n/a | n/a | Amonafide | n/a | |
| 21 | Q02880_DB06362 | n/a | DB06362 | n/a | n/a | Becatecarin | n/a | |
| 22 | Q02880_DB06421 | n/a | DB06421 | n/a | n/a | Declopramide | n/a | |
| 23 | Q02880_TSP | TSP | DB08651 | 46937170 | n/a | 3'-THIO-THYMIDINE-5'-PHOSPHATE | inhibitor |