Gene name: PPARD
Protein name: Peroxisome proliferator-activated receptor
List of molecules and drugs that interact with protein Q03181
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q03181_08S | 08S | n/a | 50897576 | n/a | 3-CHLORO-6-FLUORO-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE | n/a | |
| 2 | Q03181_1BO | 1BO | DB02145 | 263 | CHEMBL14245 | 1-BUTANOL | n/a | |
| 3 | Q03181_1FA | 1FA | n/a | 23661728 | CHEMBL400300 | [(7-{[2-(3-MORPHOLIN-4-YLPROP-1-YN-1-YL)-6-{[4-(TRIFLUOROMETHYL)PHENYL]ETHYNYL}PYRIDIN-4-YL]THIO}-2,3-DIHYDRO-1H-INDEN- 4-YL)OXY]ACETIC ACID | n/a | |
| 4 | Q03181_1KF | 1KF | DB16906 | 126752383 | CHEMBL5095171 | (3R)-3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethyl)phenyl]imidazol-1-yl]methyl]phenoxy]hexanoic acid | n/a | |
| 5 | Q03181_1PE | 1PE | n/a | 62551 | CHEMBL1229766 | PENTAETHYLENE GLYCOL | n/a | |
| 6 | Q03181_331 | 331 | n/a | 657048 | CHEMBL248906 | (2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREIDO)ETHYL]PHENOXY)-2-METHYLBUTYRIC ACID | n/a | |
| 7 | Q03181_3EQ | 3EQ | n/a | 53384645 | n/a | [(4-{butyl[2-methyl-4'-(methylsulfanyl)biphenyl-3-yl]sulfamoyl}naphthalen-1-yl)oxy]acetic acid | n/a | |
| 8 | Q03181_3OZ | 3OZ | n/a | 49837873 | n/a | [4-({(1S)-1-[(2,4-dichlorophenyl)carbamoyl]-1,3-dihydro-2H-isoindol-2-yl}methyl)-2-methylphenoxy]acetic acid | n/a | |
| 9 | Q03181_401 | 401 | DB07070 | 11711595 | CHEMBL202609 | (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid | n/a | EC50(nM) = 12.0 |
| 10 | Q03181_433 | 433 | n/a | 1517 | CHEMBL435278 | 2-(4-{3-[1-[2-(2-CHLORO-6-FLUORO-PHENYL)-ETHYL]-3-(2,3-DICHLORO-PHENYL)-UREIDO]-PROPYL}-PHENOXY)-2-METHYL-PROPIONIC ACID | n/a | |
| 11 | Q03181_7SM | 7SM | n/a | 117630549 | n/a | 6-(2-{[cyclopropyl(3'-methoxy[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid | n/a | |
| 12 | Q03181_7SS | 7SS | n/a | 117631016 | n/a | 6-(2-{[cyclopropyl(4'-methoxy[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid | n/a | |
| 13 | Q03181_7SV | 7SV | n/a | 117640352 | n/a | 6-(2-{[cyclopropyl(2'-fluoro[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid | n/a | |
| 14 | Q03181_7SY | 7SY | n/a | 117640358 | n/a | 6-(2-{[cyclopropyl(3'-fluoro[1,1'-biphenyl]-4-carbonyl)amino]methyl}phenoxy)hexanoic acid | n/a | |
| 15 | Q03181_7T1 | 7T1 | DB05416 | 9803963 | CHEMBL38943 | {2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid | agonist | Ki(nM) = 0.048 IC50(nM) = 1.0 EC50(nM) = 0.18 |
| 16 | Q03181_7TV | 7TV | n/a | 86281299 | n/a | 6-[2-({cyclopentyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid | n/a | |
| 17 | Q03181_7TY | 7TY | n/a | 117629776 | n/a | 6-[2-({cyclopentyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid | n/a | |
| 18 | Q03181_7U1 | 7U1 | n/a | 117630078 | n/a | 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(cyclopropyl)amino]methyl}phenoxy)hexanoic acid | n/a | |
| 19 | Q03181_7U4 | 7U4 | n/a | 86281821 | n/a | 6-[2-({cyclopropyl[4-(pyridin-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid | n/a | |
| 20 | Q03181_7U7 | 7U7 | n/a | 86281822 | CHEMBL4217067 | 6-[2-({cyclopropyl[4-(furan-2-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid | n/a | |
| 21 | Q03181_7UA | 7UA | n/a | 86281685 | n/a | 6-[2-({cyclopropyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid | n/a | |
| 22 | Q03181_7UD | 7UD | n/a | 86281954 | n/a | 6-[2-({benzyl[4-(furan-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid | n/a | |
| 23 | Q03181_7UG | 7UG | n/a | 86281955 | n/a | 6-[2-({benzyl[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid | n/a | |
| 24 | Q03181_7UJ | 7UJ | n/a | 86282505 | n/a | 6-(2-{[([1,1'-biphenyl]-4-carbonyl)(propan-2-yl)amino]methyl}phenoxy)hexanoic acid | n/a | |
| 25 | Q03181_7UY | 7UY | n/a | 86281164 | n/a | 6-[2-({(propan-2-yl)[4-(thiophen-3-yl)benzene-1-carbonyl]amino}methyl)phenoxy]hexanoic acid | n/a | |
| 26 | Q03181_7V1 | 7V1 | n/a | 117629789 | n/a | 6-[2-({[4-(furan-2-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid | n/a | |
| 27 | Q03181_7V4 | 7V4 | n/a | 86280885 | n/a | 6-[2-({[4-(furan-3-yl)benzene-1-carbonyl](propan-2-yl)amino}methyl)phenoxy]hexanoic acid | n/a | |
| 28 | Q03181_81O | 81O | n/a | 52948223 | CHEMBL1254756 | 5-[4-butoxy-3-[[[2-fluoranyl-4-(trifluoromethyl)phenyl]carbonylamino]methyl]phenyl]-4,6-dimethyl-pyridine-3-carboxylic acid | n/a | |
| 29 | Q03181_820 | 820 | n/a | 162540451 | n/a | (2S)-2-[[4-propoxy-3-[[[4-(trifluoromethyl)phenyl]carbonylamino]methyl]phenyl]methyl]butanoic acid | n/a | |
| 30 | Q03181_82K | 82K | n/a | 162540452 | n/a | (2S)-2-[[4-hexoxy-3-[[[4-(trifluoromethyl)phenyl]carbonylamino]methyl]phenyl]methyl]butanoic acid | n/a | |
| 31 | Q03181_85B | 85B | n/a | 162423128 | CHEMBL5084377 | 2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic acid | n/a | |
| 32 | Q03181_89L | 89L | n/a | 121269371 | CHEMBL3958704 | (E)-6-[2-[[[4-(furan-2-yl)phenyl]carbonyl-methyl-amino]methyl]phenoxy]-4-methyl-hex-4-enoic acid | n/a | |
| 33 | Q03181_8RR | 8RR | n/a | 53375028 | n/a | 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-selenazol-5-yl]methylsulfanyl]phenoxy]ethanoic acid | n/a | |
| 34 | Q03181_9LU | 9LU | n/a | 117629741 | CHEMBL4640515 | 6-[2-({2-[4-(furan-2-yl)phenyl]-5-methyl-1H-imidazol-1-yl}methyl)phenoxy]hexanoic acid | n/a | |
| 35 | Q03181_9RF | 9RF | n/a | 138454901 | n/a | {2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}methyl)sulfanyl]phenoxy}acetic acid | n/a | |
| 36 | Q03181_B7G | B7G | DB03338 | 448173 | n/a | heptyl beta-D-glucopyranoside | inhibitor | |
| 37 | Q03181_BJB | BJB | DB14801 | 68677842 | CHEMBL4091374 | 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid | agonist | |
| 38 | Q03181_BOG | BOG | n/a | 62852 | CHEMBL446037 | octyl beta-D-glucopyranoside | n/a | |
| 39 | Q03181_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 40 | Q03181_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 41 | Q03181_D32 | D32 | n/a | 44143317 | CHEMBL524063 | (2,3-dimethyl-4-{[2-(prop-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}phenoxy)acetic acid | n/a | |
| 42 | Q03181_DY6 | DY6 | DB07691 | 24941254 | CHEMBL523395 | 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid | n/a | IC50(nM) = 126.0 EC50(nM) = 1259.0 |
| 43 | Q03181_EPA | EPA | DB00159 | 446284 | CHEMBL460026 | 5,8,11,14,17-EICOSAPENTAENOIC ACID | agonist | IC50(nM) = 4000.0 |
| 44 | Q03181_ET1 | ET1 | DB07724 | 11395145 | CHEMBL1232583 | 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid | agonist | |
| 45 | Q03181_GNI | GNI | n/a | 9549255 | CHEMBL374078 | (3-{4-[2-(2,4-DICHLORO-PHENOXY)-ETHYLCARBAMOYL]-5-PHENYL-ISOXAZOL-3-YL}-PHENYL)-ACETIC ACID | n/a | |
| 46 | Q03181_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | agonist | |
| 47 | Q03181_GW0 | GW0 | n/a | 9934458 | CHEMBL38508 | {4-[({2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid | n/a | |
| 48 | Q03181_IL2 | IL2 | n/a | 51397006 | n/a | (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid | n/a | |
| 49 | Q03181_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 50 | Q03181_JZR | JZR | n/a | 181215 | n/a | hexyl beta-D-glucopyranoside | n/a | |
| 51 | Q03181_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 52 | Q03181_K55 | K55 | n/a | 16220190 | CHEMBL375471 | (2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]benzyl}butanoic acid | n/a | |
| 53 | Q03181_KKB | KKB | DB12390 | 11236126 | CHEMBL230158 | Seladelpar | agonist | |
| 54 | Q03181_L41 | L41 | DB08078 | 6603901 | CHEMBL153057 | {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid | agonist | IC50(nM) = 13.0 Kd(nM) = 76.0 EC50(nM) = 6.0 koff(s-1) = 0.43 |
| 55 | Q03181_LOO | LOO | n/a | 168477242 | CHEMBL5417169 | 2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid | n/a | |
| 56 | Q03181_P7F | P7F | DB15212 | 11526038 | CHEMBL247951 | (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid | n/a | |
| 57 | Q03181_PE3 | PE3 | n/a | 656926 | n/a | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL | n/a | |
| 58 | Q03181_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 59 | Q03181_PEM | PEM | DB01393 | 39042 | CHEMBL264374 | 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID | agonist | EC50(nM) = 18900.0 |
| 60 | Q03181_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 61 | Q03181_PGO | PGO | DB04349 | 439846 | n/a | S-1,2-PROPANEDIOL | n/a | |
| 62 | Q03181_VCA | VCA | DB04801 | 5282761 | CHEMBL1236642 | VACCENIC ACID | inhibitor | |
| 63 | Q03181_WLM | WLM | n/a | 13813285 | n/a | 5-CHLORO-2-METHOXY-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]BENZAMIDE | n/a | |
| 64 | Q03181_Z00 | Z00 | n/a | 49867890 | n/a | 4-[2-[[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]AMINO]ETHYL]-N-(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)BENZENESULFONAMIDE | n/a | |
| 65 | Q03181_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 66 | Q03181_LNL | LNL | DB00132 | 5280934 | CHEMBL8739 | alpha-Linolenic acid | n/a | IC50(nM) = 16000.0 |
| 67 | Q03181_DB00197 | n/a | DB00197 | n/a | n/a | Troglitazone | n/a | |
| 68 | Q03181_2PP | 2PP | DB00313 | n/a | n/a | Valproic acid | n/a | |
| 69 | Q03181_DB00374 | n/a | DB00374 | n/a | n/a | Treprostinil | agonist | |
| 70 | Q03181_DB00412 | n/a | DB00412 | n/a | n/a | Rosiglitazone | n/a | EC50(nM) = 5248.0 |
| 71 | Q03181_DB00605 | n/a | DB00605 | n/a | n/a | Sulindac | negative modulator | |
| 72 | Q03181_PHT | PHT | DB02746 | 1017;18183610; | CHEMBL1045 | Phthalic Acid | n/a | |
| 73 | Q03181_ELA | ELA | DB04224 | 637517 | CHEMBL460657 | Oleic Acid | n/a | |
| 74 | Q03181_DB05187 | n/a | DB05187 | n/a | n/a | Elafibranor | agonist | |
| 75 | Q03181_DB05188 | n/a | DB05188 | n/a | n/a | KD3010 | n/a | |
| 76 | Q03181_DB09006 | n/a | DB09006 | n/a | n/a | Clinofibrate | n/a | |
| 77 | Q03181_F5A | F5A | DB13873 | 64929 | CHEMBL981 | Fenofibric acid | unknown |