Gene name: Fnta
Protein name: Protein farnesyltransferase/geranylgeranyltransferase type-1
List of molecules and drugs that interact with protein Q04631
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q04631_1NH | 1NH | n/a | 447473 | n/a | (2E,6E)-8-[(3-BENZOYLBENZYL)OXY]-3,7-DIMETHYLOCTA-2,6-DIENYL TRIHYDROGEN DIPHOSPHATE | n/a | |
| 2 | Q04631_2C5 | 2C5 | DB06953 | 5287467 | n/a | 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE | n/a | |
| 3 | Q04631_2NH | 2NH | n/a | 447474 | n/a | N-ACETYL-S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]-L-CYSTEINYL-D-VALYL-L-ISOLEUCYL-L-METHIONINE | n/a | |
| 4 | Q04631_336 | 336 | DB06448 | 148195 | CHEMBL298734 | 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE | n/a | |
| 5 | Q04631_3PZ | 3PZ | n/a | 644328 | CHEMBL1738728 | (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile | n/a | |
| 6 | Q04631_60I | 60I | n/a | 156595851 | CHEMBL4758112 | [4-[[3-(2,2-dimethylpropyl)-1~{H}-benzimidazol-2-yl]methyl]piperazin-1-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone | n/a | |
| 7 | Q04631_736 | 736 | DB07216 | 9547909 | CHEMBL372164 | (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE | n/a | |
| 8 | Q04631_778 | 778 | DB07227 | 216454 | CHEMBL279433 | 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE | n/a | |
| 9 | Q04631_7TM | 7TM | n/a | 66545760 | CHEMBL2171843 | 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl hexylcarbamate | n/a | |
| 10 | Q04631_7TP | 7TP | n/a | 54762597 | CHEMBL2171691 | 5-{(3R)-3-(4-hydroxybenzyl)-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl}furan-2-carbaldehyde | n/a | |
| 11 | Q04631_7TQ | 7TQ | n/a | 54762496 | CHEMBL2171687 | 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl benzylcarbamate | n/a | |
| 12 | Q04631_ACE | ACE | n/a | 177 | CHEMBL170365 | ACETYL GROUP | n/a | |
| 13 | Q04631_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 14 | Q04631_ACY | ACY | DB03166 | 176;21980959;160748163; | CHEMBL539 | ACETIC ACID | n/a | |
| 15 | Q04631_BMV | BMV | DB12234 | 448545 | CHEMBL351706 | 3-BENZYL-1-(1H-IMIDAZOL-4-YLMETHYL)-4-(THIEN-2-YLSULFONYL)-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE | n/a | |
| 16 | Q04631_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 17 | Q04631_DMA | DMA | DB01785 | 647 | CHEMBL343480 | DIMETHYLALLYL DIPHOSPHATE | n/a | |
| 18 | Q04631_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 19 | Q04631_ED1 | ED1 | n/a | 25181318 | n/a | 3-{2'-[{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)sulfamoyl]biphenyl-3-yl}propanoic acid | n/a | |
| 20 | Q04631_ED2 | ED2 | n/a | 11294760 | CHEMBL215769 | N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-1-methyl-1H-imidazole-4-sulfonamide | n/a | |
| 21 | Q04631_ED4 | ED4 | n/a | 16086150 | CHEMBL385072 | tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino}methyl)piperidine-1-carboxylate | n/a | |
| 22 | Q04631_ED7 | ED7 | n/a | 25181317 | n/a | N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-2-methylbenzenesulfonamide | n/a | |
| 23 | Q04631_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 24 | Q04631_FAR | FAR | n/a | 444108 | n/a | FARNESYL | n/a | |
| 25 | Q04631_FII | FII | DB07771 | 445015 | n/a | [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID | n/a | |
| 26 | Q04631_FPP | FPP | DB07780 | 445713 | CHEMBL69330 | FARNESYL DIPHOSPHATE | n/a | |
| 27 | Q04631_FTH | FTH | n/a | 5288261 | CHEMBL29946 | 1-[2-(4-CYANO-BENZYLAMINO)-3-(3-METHYL-3H-IMIDAZOL-4-YL)-PROPIONYL]-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE | n/a | |
| 28 | Q04631_FTI | FTI | n/a | 4631604 | CHEMBL30059 | 1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE | n/a | |
| 29 | Q04631_FTL | FTL | n/a | 447390 | CHEMBL27843 | 4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETHYL)-AMINO]-2-NAPHTHALEN-1-YL-BENZONITRILE | n/a | |
| 30 | Q04631_GBO | GBO | n/a | 25141075 | CHEMBL1229267 | (2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate | n/a | |
| 31 | Q04631_GER | GER | n/a | 446073 | n/a | GERAN-8-YL GERAN | n/a | |
| 32 | Q04631_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 33 | Q04631_GRG | GRG | n/a | 447277 | CHEMBL1229266 | GERANYLGERANYL DIPHOSPHATE | n/a | |
| 34 | Q04631_HFP | HFP | DB07895 | 46937103 | n/a | ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID | n/a | |
| 35 | Q04631_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 36 | Q04631_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 37 | Q04631_MGM | MGM | DB08180 | 447278 | CHEMBL71360 | 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE | n/a | |
| 38 | Q04631_NH7 | NH7 | n/a | 25163967 | n/a | 2-[(S)-(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-N-morpholin-4-yl-7-phenyl-1-benzofuran-5-carboxamide | n/a | |
| 39 | Q04631_NH8 | NH8 | n/a | 25163968 | n/a | 3-{2-[(S)-(4-cyanophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-5-nitro-1-benzofuran-7-yl}benzonitrile | n/a | |
| 40 | Q04631_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 41 | Q04631_PPV | PPV | DB04160 | 1023;21961011; | CHEMBL1160571 | PYROPHOSPHATE | n/a | |
| 42 | Q04631_TIN | TIN | n/a | 447312 | CHEMBL29982 | 2-{(5-{[BUTYL-(2-CYCLOHEXYL-ETHYL)-AMINO]-METHYL}-2'-METHYL-BIPHENYL-2-CARBONYL)-AMINO]-4-METHYLSULFANYL-BUTYRIC ACID | n/a | |
| 43 | Q04631_TRS | TRS | DB03754 | 3777159;88088752;152743085; | n/a | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 44 | Q04631_XMY | XMY | n/a | 165412423 | CHEMBL5182445 | (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one | n/a |