Gene name: GRIN1
Protein name: Glutamate receptor ionotropic,
List of molecules and drugs that interact with protein Q05586
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q05586_5YC | 5YC | n/a | 20938953 | CHEMBL3797274 | 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one | n/a | |
| 2 | Q05586_5YD | 5YD | n/a | 5165428 | n/a | 4-[[(4-fluorophenyl)sulfonylamino]methyl]-~{N}-(pyridin-3-ylmethyl)benzamide | n/a | |
| 3 | Q05586_5YE | 5YE | n/a | 118017713 | CHEMBL4583809 | 6-[[ethyl-(4-fluorophenyl)amino]methyl]-2,3-dihydro-1~{H}-cyclopenta[3,4][1,3]thiazolo[1,4-~{a}]pyrimidin-8-one | n/a | |
| 4 | Q05586_67H | 67H | n/a | 118017587 | CHEMBL3800614 | 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide | n/a | |
| 5 | Q05586_67J | 67J | n/a | 118009479 | CHEMBL3797818 | N-ethyl-7-{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide | n/a | |
| 6 | Q05586_6RM | 6RM | n/a | 118009262 | CHEMBL3800265 | 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{R},2~{R})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one | n/a | |
| 7 | Q05586_6RV | 6RV | n/a | 127046129 | CHEMBL3799213 | (1~{R},2~{R})-2-[7-[[5-chloranyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-5-oxidanylidene-2-(trifluoromethyl)-[1,3]thiazolo[3,2-a]pyrimidin-3-yl]cyclopropane-1-carbonitrile | n/a | |
| 8 | Q05586_7H0 | 7H0 | n/a | 118017739 | CHEMBL3799694 | 7-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-N-ethyl-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide | n/a | |
| 9 | Q05586_7H2 | 7H2 | n/a | 134157459 | CHEMBL3983039 | (1R,2R)-2-(2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile | n/a | |
| 10 | Q05586_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 11 | Q05586_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 12 | Q05586_GLU | GLU | DB00142 | 33032;44272391;88747398; | CHEMBL575060 | GLUTAMIC ACID | n/a | |
| 13 | Q05586_GLY | GLY | DB00145 | 750;5257127; | CHEMBL773 | GLYCINE | n/a | |
| 14 | Q05586_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 15 | Q05586_J86 | J86 | n/a | 6604872 | CHEMBL86313 | [(1S)-1-[[7-bromanyl-2,3-bis(oxidanylidene)-1,4-dihydroquinoxalin-5-yl]methylamino]ethyl]phosphonic acid | n/a | |
| 16 | Q05586_JC9 | JC9 | DB11823 | 182137 | CHEMBL395091 | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one | antagonist | |
| 17 | Q05586_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 18 | Q05586_GGL | GGL | DB00142 | 33032;44272391;88747398; | CHEMBL575060 | Glutamic acid | n/a | |
| 19 | Q05586_DB00454 | n/a | DB00454 | n/a | n/a | Meperidine | antagonist | |
| 20 | Q05586_DB01043 | n/a | DB01043 | n/a | n/a | Memantine | binder | Ki(nM) = 1000.0 IC50(nM) = 1020.0 |
| 21 | Q05586_DB01173 | n/a | DB01173 | n/a | n/a | Orphenadrine | antagonist | |
| 22 | Q05586_DK1 | DK1 | DB01931 | 1779;5288072; | CHEMBL50267 | 5,7-Dichlorokynurenic acid | inhibitor | |
| 23 | Q05586_DSN | DSN | DB03929 | 71077;6857549; | CHEMBL285123 | D-Serine | inhibitor | |
| 24 | Q05586_AC5 | AC5 | DB04620 | 2901;6918961; | CHEMBL295830 | Cycloleucine | inhibitor | |
| 25 | Q05586_DB05824 | n/a | DB05824 | n/a | n/a | CNS-5161 | n/a | |
| 26 | Q05586_SC2 | SC2 | DB06151 | 12035 | CHEMBL600 | Acetylcysteine | activator | |
| 27 | Q05586_AG2 | AG2 | DB08838 | 199 | CHEMBL58343 | Agmatine | antagonist | |
| 28 | Q05586_DB08954 | n/a | DB08954 | n/a | n/a | Ifenprodil | antagonist | Ki(nM) = 10.0 IC50(nM) = 66.0 |