Gene name: PTPN11
Protein name: Tyrosine-protein phosphatase non-receptor
List of molecules and drugs that interact with protein Q06124
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q06124_2WT | 2WT | n/a | 91667928 | CHEMBL3319391 | 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid | n/a | |
| 2 | Q06124_33I | 33I | n/a | 130408604;137215914; | CHEMBL5196693 | 6-(4-amino-4-methylpiperidin-1-yl)-3-(3-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 3 | Q06124_37I | 37I | n/a | 132166808 | CHEMBL5170633 | 4-[6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl]-3-chloro-N-methylpyridin-2-amine | n/a | |
| 4 | Q06124_3CW | 3CW | n/a | 134182781 | CHEMBL5280755 | [3-(4-amino-4-methylpiperidin-1-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl]methanol | n/a | |
| 5 | Q06124_3ED | 3ED | n/a | 146364381 | CHEMBL5196403 | 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3H)-one | n/a | |
| 6 | Q06124_3LU | 3LU | n/a | 137348157 | n/a | 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyr idinium | n/a | |
| 7 | Q06124_4Q4 | 4Q4 | n/a | 134183206 | CHEMBL4752026 | {3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl}methanol | n/a | |
| 8 | Q06124_5OA | 5OA | n/a | 76966642 | CHEMBL4473316 | 5-[2,3-bis(chloranyl)phenyl]-2-[(3~{R},5~{S})-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine | n/a | |
| 9 | Q06124_5OD | 5OD | n/a | 118238298 | CHEMBL4060033 | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine | n/a | |
| 10 | Q06124_83Q | 83Q | n/a | 118239405 | CHEMBL4789106 | 6-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-3-[2,3-bis(chloranyl)phenyl]sulfanyl-pyrazin-2-amine | n/a | |
| 11 | Q06124_8J6 | 8J6 | n/a | 131842071 | CHEMBL4088619 | 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine | n/a | |
| 12 | Q06124_B2B | B2B | n/a | 53318991 | n/a | (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid | n/a | |
| 13 | Q06124_CAT | CAT | DB02779 | 8153 | CHEMBL1180004 | DODECANE-TRIMETHYLAMINE | inhibitor | |
| 14 | Q06124_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 15 | Q06124_DYV | DYV | n/a | 135567405 | CHEMBL4796034 | 1-(3-chloro-4-{[1-(2-hydroxy-3-methoxyphenyl)-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl]methyl}benzene-1-carbonyl)-L-proline | n/a | |
| 16 | Q06124_DZJ | DZJ | n/a | 137349217 | CHEMBL4207669 | 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one | n/a | |
| 17 | Q06124_DZS | DZS | n/a | 137349219 | CHEMBL4754197 | 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid | n/a | |
| 18 | Q06124_DZV | DZV | n/a | 135546931 | CHEMBL1434615 | 4-[(2-chlorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one | n/a | |
| 19 | Q06124_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 20 | Q06124_EOH | EOH | DB00898 | 702 | CHEMBL545 | ETHANOL | n/a | |
| 21 | Q06124_FIZ | FIZ | n/a | 166607331 | n/a | 2-[(3S,4R)-4-azanyl-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-[2,3-bis(chloranyl)phenyl]-3-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-one | n/a | |
| 22 | Q06124_FLC | FLC | n/a | 31348 | n/a | CITRATE ANION | n/a | |
| 23 | Q06124_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 24 | Q06124_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 25 | Q06124_JE1 | JE1 | n/a | 124150360 | CHEMBL4523033 | 2-[4-(aminomethyl)-4-methylpiperidin-1-yl]-5-{[2-(trifluoromethyl)pyridin-3-yl]sulfanyl}pyrimidin-4(3H)-one | n/a | |
| 26 | Q06124_JE4 | JE4 | n/a | 124140941 | CHEMBL4469071 | 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)-5-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 27 | Q06124_JE7 | JE7 | n/a | 137331590 | CHEMBL4514244 | 5-[(2,3-dichlorophenyl)sulfanyl]-3H-imidazo[4,5-b]pyridin-2-amine | n/a | |
| 28 | Q06124_JEA | JEA | n/a | 124147932 | CHEMBL4439006 | 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclopropylamino)pyridin-4-yl]-5-methyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 29 | Q06124_JED | JED | n/a | 22548785 | CHEMBL4548850 | 3-(4-bromophenyl)-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid | n/a | |
| 30 | Q06124_JEJ | JEJ | n/a | 137331588 | CHEMBL4445754 | 3-(2-chlorophenyl)-6-{4-[(dimethylamino)methyl]phenyl}-5-methyl[1,2]oxazolo[4,5-c]pyridin-4(5H)-one | n/a | |
| 31 | Q06124_JZG | JZG | n/a | 25262527 | CHEMBL590043 | 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid | n/a | |
| 32 | Q06124_KID | KID | n/a | 168490174 | n/a | 2-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-5-[2,3-bis(chloranyl)phenyl]-3-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-one | n/a | |
| 33 | Q06124_MLT | MLT | DB03499 | 92824 | CHEMBL225986 | D-MALATE | n/a | |
| 34 | Q06124_P8O | P8O | n/a | 155796647 | CHEMBL5276842 | (1~{S})-1'-[5-[2-(trifluoromethyl)pyridin-3-yl]sulfanyl-3~{H}-imidazo[4,5-b]pyrazin-2-yl]spiro[1,3-dihydroindene-2,4'-piperidine]-1-amine | n/a | |
| 35 | Q06124_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 36 | Q06124_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 37 | Q06124_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 38 | Q06124_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 39 | Q06124_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 40 | Q06124_U70 | U70 | n/a | 164850792 | CHEMBL5290513 | [(1~{S},6~{R},7~{S})-3-[3-[2,3-bis(chloranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyrazin-6-yl]-7-(4-methyl-1,3-thiazol-2-yl)-3-azabicyclo[4.1.0]heptan-7-yl]methanamine | n/a | |
| 41 | Q06124_U9Y | U9Y | n/a | 132166923 | CHEMBL5191319 | 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | n/a | |
| 42 | Q06124_UNX | UNX | n/a | |||||
| 43 | Q06124_VKP | VKP | n/a | 118239942 | CHEMBL4762625 | 6-(4-amino-4-methylpiperidin-1-yl)-3-[(2,3-dichlorophenyl)sulfanyl]pyrazin-2-amine | n/a | |
| 44 | Q06124_VKS | VKS | DB19137 | 118238370 | CHEMBL4650521 | (3S,4S)-8-{6-amino-5-[(2-amino-3-chloropyridin-4-yl)sulfanyl]pyrazin-2-yl}-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine | n/a | |
| 45 | Q06124_YR2 | YR2 | n/a | 139512018 | CHEMBL5314471 | (3R)-1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-3H-spiro[[1]benzofuran-2,4'-piperidin]-3-amine | n/a | |
| 46 | Q06124_YT2 | YT2 | n/a | 139512236 | n/a | (1S)-1-{6-[(1S)-1-amino-1,3-dihydrospiro[indene-2,4'-piperidin]-1'-yl]-3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-5-yl}ethan-1-ol | n/a | |
| 47 | Q06124_ZH5 | ZH5 | n/a | 134473735 | CHEMBL5395323 | 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine | n/a | |
| 48 | Q06124_ZJX | ZJX | n/a | 132166959 | CHEMBL4776940 | 1-[(3P)-3-(3-chloro-2-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | n/a |