Gene name: PDE4B
Protein name: 3',5'-cyclic-AMP phosphodiesterase 4B
List of molecules and drugs that interact with protein Q07343
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q07343_066 | 066 | DB12137 | 9827968 | CHEMBL570015 | 6-{[3-(dimethylcarbamoyl)phenyl]sulfonyl}-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | n/a | |
| 2 | Q07343_0CP | 0CP | n/a | 9861730 | CHEMBL1229569 | 5-{3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl}tetrahydropyrimidin-2(1H)-one | n/a | |
| 3 | Q07343_19T | 19T | n/a | 15951010 | CHEMBL1782306 | (4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid | n/a | |
| 4 | Q07343_1S1 | 1S1 | n/a | 71598545 | CHEMBL2402509 | 2-ethyl-2-{[4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-yl]amino}butanenitrile | n/a | |
| 5 | Q07343_20A | 20A | DB06909 | 9821178 | CHEMBL521203 | 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide | n/a | IC50(nM) = 3.16 |
| 6 | Q07343_2O5 | 2O5 | n/a | 74221165 | CHEMBL3315251 | (4-{[4-(3-chlorophenyl)-6-cyclopropyl-1,3,5-triazin-2-yl]amino}phenyl)acetic acid | n/a | |
| 7 | Q07343_3OJ | 3OJ | DB16039 | 24806574 | CHEMBL4467344 | 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzene-1,2-dicarbonitrile | inhibitor | |
| 8 | Q07343_5RM | 5RM | DB01647 | 449190 | CHEMBL603830 | (5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one | inhibitor | IC50(nM) = 420.0 |
| 9 | Q07343_6DE | 6DE | DB03807 | 656968 | CHEMBL519827 | 1-(2-CHLOROPHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | n/a | IC50(nM) = 56.0 |
| 10 | Q07343_6M5 | 6M5 | n/a | 71719394 | CHEMBL2326941 | (4~{a}~{S},8~{a}~{R})-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-one | n/a | |
| 11 | Q07343_6QQ | 6QQ | n/a | 127020999 | n/a | 6-[[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-3-yl]oxy]-5-chloranyl-2-(4-oxidanylidenepentoxy)pyridine-3-carbonitrile | n/a | |
| 12 | Q07343_7DE | 7DE | DB01959 | 656969 | CHEMBL1230564 | 3,5-DIMETHYL-1-(3-NITROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | n/a | IC50(nM) = 33.0 |
| 13 | Q07343_8BR | 8BR | DB03349 | 168120 | CHEMBL1230617 | 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE | inhibitor | |
| 14 | Q07343_988 | 988 | n/a | 9819356 | CHEMBL127944 | 8-(3-nitrophenyl)-6-(pyridin-4-ylmethyl)quinoline | n/a | |
| 15 | Q07343_9VE | 9VE | n/a | 137348866 | n/a | [(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-1-ium-4-yl]-1-[4-[bis(fluoranyl)methoxy]-3-(cyclopropylmethoxy)phenyl]ethyl] (2~{S})-1-[3-(dimethylcarbamoyl)phenyl]sulfonylpyrrolidine-2-carboxylate | n/a | |
| 16 | Q07343_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 17 | Q07343_AMP | AMP | DB00131 | 6083 | CHEMBL752 | ADENOSINE MONOPHOSPHATE | product of | |
| 18 | Q07343_ARS | ARS | n/a | 23969 | CHEMBL1231052 | ARSENIC | n/a | |
| 19 | Q07343_B3P | B3P | DB02676 | 125132 | CHEMBL63859 | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | n/a | |
| 20 | Q07343_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 21 | Q07343_CIO | CIO | DB03849 | n/a | CHEMBL511115 | CILOMILAST | inhibitor | |
| 22 | Q07343_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 23 | Q07343_FIL | FIL | DB02660 | 9578243 | CHEMBL590754 | (1E)-1-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ETHANONE O-(AMINOCARBONYL)OXIME | inhibitor | |
| 24 | Q07343_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 25 | Q07343_HBT | HBT | n/a | 1021494 | n/a | (6S)-6-methyl-2-{[(2-nitrophenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide | n/a | |
| 26 | Q07343_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 27 | Q07343_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 28 | Q07343_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | |
| 29 | Q07343_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 30 | Q07343_NVW | NVW | n/a | 71463568 | CHEMBL2385758 | N-tert-butyl-2-{4-[(5,5-dioxido-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl}acetamide | n/a | |
| 31 | Q07343_PIL | PIL | DB01791 | 154575 | CHEMBL42126 | 3-(CYCLOPENTYLOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-METHOXYBENZAMIDE | inhibitor | Ki(nM) = 0.4 IC50(nM) = 0.041 |
| 32 | Q07343_QPC | QPC | n/a | 71741428 | CHEMBL2442472 | 4-[(4-{2-[(2,2-dimethylpropyl)amino]-2-oxoethyl}phenyl)amino]-2-phenylpyrimidine-5-carboxamide | n/a | |
| 33 | Q07343_ROF | ROF | DB01656 | 449193 | CHEMBL193240 | 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE | inhibitor | Ki(nM) = 0.398107 IC50(nM) = 0.15 |
| 34 | Q07343_ROL | ROL | DB04149 | 448055 | CHEMBL430893 | ROLIPRAM | inhibitor | IC50(nM) = 39.81 |
| 35 | Q07343_SK4 | SK4 | n/a | 11280182 | CHEMBL462150 | 4-[(3-methoxyphenyl)amino]-6-(methylsulfonyl)quinoline-3-carboxamide | n/a | |
| 36 | Q07343_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 37 | Q07343_VDN | VDN | DB00862 | 110634;135400189; | CHEMBL1520 | 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE | n/a | |
| 38 | Q07343_VIA | VIA | DB00203 | 5212;5281023;135398744; | CHEMBL192 | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | n/a | |
| 39 | Q07343_VL9 | VL9 | n/a | n/a | n/a | [(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-4-yl]-1-(3,4-dimethoxyphenyl)ethyl] 5-[[[(1~{R})-2-[[(3~{R})-1-azabicyclo[2.2.2]octan-3-yl]oxy]-2-oxidanylidene-1-phenyl-ethyl]amino]methyl]thiophene-2-carboxylate | n/a | |
| 40 | Q07343_Z72 | Z72 | n/a | 24849380 | CHEMBL1096812 | 8-(cyclopentyloxy)-4-[(3,5-dichloropyridin-4-yl)amino]-7-methoxy-2H-chromen-2-one | n/a | |
| 41 | Q07343_ZG1 | ZG1 | n/a | 10455087 | n/a | 1-ethyl-5-[3-(2-oxo-2-pyrrolidin-1-ylethyl)-1,2,4-oxadiazol-5-yl]-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine | n/a | |
| 42 | Q07343_ZG2 | ZG2 | n/a | 46945866 | n/a | 5-[5-benzyl-4-(2-oxo-2-pyrrolidin-1-ylethyl)-1,3-oxazol-2-yl]-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine | n/a | |
| 43 | Q07343_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 44 | Q07343_CFF | CFF | DB00201 | 2519 | CHEMBL113 | Caffeine | inhibitor | |
| 45 | Q07343_TEP | TEP | DB00277 | 2153 | CHEMBL190 | Theophylline | inhibitor | Ki(nM) = 56800.0 IC50(nM) = 1780000.0 |
| 46 | Q07343_DB00651 | n/a | DB00651 | n/a | n/a | Dyphylline | inhibitor | |
| 47 | Q07343_DB00824 | n/a | DB00824 | n/a | n/a | Enprofylline | inhibitor | Ki(nM) = 43100.0 |
| 48 | Q07343_DB01088 | n/a | DB01088 | n/a | n/a | Iloprost | inducer | |
| 49 | Q07343_EV1 | EV1 | DB01113 | 4680 | CHEMBL19224 | Papaverine | inhibitor | |
| 50 | Q07343_37T | 37T | DB01412 | 5429 | CHEMBL1114 | Theobromine | inhibitor | |
| 51 | Q07343_DB01954 | n/a | DB01954 | n/a | n/a | Rolipram | inhibitor | |
| 52 | Q07343_DB03606 | n/a | DB03606 | n/a | n/a | (S)-Rolipram | inhibitor | |
| 53 | Q07343_CME | CME | DB04530 | n/a | n/a | S,S-(2-Hydroxyethyl)Thiocysteine | inhibitor | |
| 54 | Q07343_DB05219 | n/a | DB05219 | n/a | n/a | Crisaborole | inhibitor | |
| 55 | Q07343_AVL | AVL | DB05266 | 3671 | CHEMBL19449 | Ibudilast | inhibitor | IC50(nM) = 65.0 |
| 56 | Q07343_NPV | NPV | DB08299 | 9999276 | CHEMBL74078 | 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid | n/a | IC50(nM) = 0.6 |