Gene name: MCL1
Protein name: Induced myeloid leukemia
List of molecules and drugs that interact with protein Q07820
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q07820_19G | 19G | n/a | 70680245 | CHEMBL2314173 | 3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-benzothiophene-2-carboxylic acid | n/a | |
| 2 | Q07820_19H | 19H | n/a | 70680244 | CHEMBL2314209 | 6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1H-indole-2-carboxylic acid | n/a | |
| 3 | Q07820_2UU | 2UU | n/a | 73167580 | CHEMBL3126304 | 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid | n/a | |
| 4 | Q07820_2UV | 2UV | n/a | 13548111 | CHEMBL3126318 | 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid | n/a | |
| 5 | Q07820_4M6 | 4M6 | n/a | 91754241 | CHEMBL3426319 | 1-[3-(naphthalen-1-yloxy)propyl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid | n/a | |
| 6 | Q07820_4M7 | 4M7 | n/a | 91754239 | n/a | (1R)-7-[3-(naphthalen-1-yloxy)propyl]-3,4-dihydro-2H-[1,4]thiazepino[2,3,4-hi]indole-6-carboxylic acid 1-oxide | n/a | |
| 7 | Q07820_5WK | 5WK | n/a | 762936 | CHEMBL1312571 | 2-[5-[1,1,2,2-tetrakis(fluoranyl)ethyl]-1~{H}-pyrazol-3-yl]phenol | n/a | |
| 8 | Q07820_5WL | 5WL | n/a | 90085661 | CHEMBL3785892 | 6-chloranyl-~{N}-methylsulfonyl-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxamide | n/a | |
| 9 | Q07820_5X2 | 5X2 | n/a | 90083030 | CHEMBL3785312 | 3-[3-(4-chloranyl-3,5-dimethyl-phenoxy)propyl]-~{N}-(phenylsulfonyl)-1~{H}-indole-2-carboxamide | n/a | |
| 10 | Q07820_5X3 | 5X3 | n/a | 118704913 | CHEMBL3785866 | 5-[[6-chloranyl-3-[3-(4-chloranyl-3,5-dimethyl-phenoxy)propyl]-7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-1~{H}-indol-2-yl]carbonylsulfamoyl]furan-2-carboxylic acid | n/a | |
| 11 | Q07820_6AK | 6AK | n/a | 118406960 | CHEMBL4086356 | 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid | n/a | |
| 12 | Q07820_6AL | 6AL | n/a | 118394714 | CHEMBL4082389 | 3-({6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-2-carbonyl}amino)benzoic acid | n/a | |
| 13 | Q07820_865 | 865 | n/a | 68937287 | n/a | 7-[2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl]-3-[3-(naphthalen-1-yloxy)propyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl]-1H-indole-2-carboxylic acid | n/a | |
| 14 | Q07820_9EA | 9EA | n/a | 68938909 | CHEMBL3417706 | 7-(3-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-1,5-dimethyl-1H-pyrazol-4-yl)-3-{3-[(naphthalen-1-yl)oxy]propyl}-1-[(pyridin-3-yl)methyl]-1H-indole-2-carboxylic acid | n/a | |
| 15 | Q07820_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 16 | Q07820_ADM | ADM | DB03627 | n/a | n/a | ADAMANTANE | n/a | |
| 17 | Q07820_BNL | BNL | n/a | 7095 | CHEMBL14092 | BIPHENYL | n/a | |
| 18 | Q07820_CD | CD | n/a | 31193 | n/a | CADMIUM ION | n/a | |
| 19 | Q07820_CJY | CJY | n/a | 25100119 | CHEMBL2314198 | 3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid | n/a | |
| 20 | Q07820_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 21 | Q07820_CN7 | CN7 | n/a | 25144061 | CHEMBL3417694 | 7-(2-methylphenyl)-1-[2-(morpholin-4-yl)ethyl]-3-{3-[(naphthalen-1-yl)oxy]propyl}-1H-indole-2-carboxylic acid | n/a | |
| 22 | Q07820_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 23 | Q07820_E4K | E4K | n/a | 68935925 | CHEMBL5200558 | 7-(2-methylphenyl)-3-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl]-1~{H}-indole-2-carboxylic acid | n/a | |
| 24 | Q07820_E4Q | E4Q | n/a | 135397733 | CHEMBL4443085 | 7-[3-[(1,5-dimethylpyrazol-3-yl)methylsulfanylmethyl]-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid | n/a | |
| 25 | Q07820_E4W | E4W | DB14792 | 131634760 | CHEMBL4297482 | AZD5991 | n/a | |
| 26 | Q07820_ECM | ECM | n/a | 118406995 | CHEMBL4083870 | 7-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-3-carboxylic acid | n/a | |
| 27 | Q07820_ECY | ECY | n/a | 118406988 | CHEMBL4094135 | 3-({11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}methyl)benzoic acid | n/a | |
| 28 | Q07820_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 29 | Q07820_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 30 | Q07820_HVN | HVN | n/a | 139592528 | n/a | 3-[3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1~{H}-indole-2-carboxylic acid | n/a | |
| 31 | Q07820_J3E | J3E | n/a | 138393391 | CHEMBL4521431 | 7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid | n/a | |
| 32 | Q07820_JL5 | JL5 | n/a | 138756813 | CHEMBL4537357 | (2~{R})-2-[5-[3-chloranyl-2-methyl-5-(4-methylpiperazin-1-yl)-4-oxidanyl-phenyl]-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid | n/a | |
| 33 | Q07820_JL8 | JL8 | n/a | 138756811 | CHEMBL4515048 | (2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid | n/a | |
| 34 | Q07820_JLE | JLE | n/a | 135340006 | CHEMBL4436725 | (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid | n/a | |
| 35 | Q07820_JLK | JLK | n/a | 138756814 | CHEMBL4458675 | (2~{R})-2-[[6-ethyl-5-(2-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid | n/a | |
| 36 | Q07820_KJP | KJP | n/a | 134828256 | CHEMBL4469869 | 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-1H-indole-5-carboxylic acid | n/a | |
| 37 | Q07820_LC3 | LC3 | n/a | 72793103 | CHEMBL3126113 | 7-(4-carboxyphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid | n/a | |
| 38 | Q07820_LC6 | LC6 | n/a | 72793176 | CHEMBL3126119 | 7-(4-{[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}-2-methylphenyl)-3-[3-(naphthalen-1-yloxy)propyl]pyrazolo[1,5-a]pyridine-2-carboxylic acid | n/a | |
| 39 | Q07820_LMV | LMV | n/a | 145994351 | n/a | (2~{S})-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-~{N}-(2-methylpropylsulfonyl)-2,3-dihydro-1,4-benzoxazine-6-carboxamide | n/a | |
| 40 | Q07820_LOD | LOD | n/a | 138320064 | CHEMBL4449176 | (3S)-5'-chloro-5-(cyclobutylmethyl)-2',3',4,5-tetrahydro-2H-spiro[1,5-benzoxazepine-3,1'-indene]-7-carboxylic acid | n/a | |
| 41 | Q07820_LOJ | LOJ | n/a | 138320065 | CHEMBL4533049 | (3S)-5-(cyclobutylmethyl)-3-(2,4-dichlorophenyl)-2,3,4,5-tetrahydro-1,5-benzoxazepine-7-carboxylic acid | n/a | |
| 42 | Q07820_N0J | N0J | n/a | 118910208 | CHEMBL4560418 | (4S,7aR,9aR,10S,11E,15R)-6'-chloro-15-ethyl-10-hydroxy-3',4',7a,8,9,9a,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione | n/a | |
| 43 | Q07820_N0M | N0M | n/a | 118910252 | CHEMBL4465718 | (4S,7aR,9aR,10S,15R)-6'-chloro-10-hydroxy-15-methyl-3',4',7a,8,9,9a,10,11,12,13,14,15-dodecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione | n/a | |
| 44 | Q07820_N0P | N0P | n/a | 138753323 | CHEMBL5193416 | (4S)-5'-chloro-2',3',7,8,9,10,11,12-octahydro-3H,5H,14H-spiro[1,19-etheno-16lambda~6~-[1,4]oxazepino[3,4-i][1,4,5,10]oxathiadiazacyclohexadecine-4,1'-indene]-16,16,18(15H,17H)-trione | n/a | |
| 45 | Q07820_N0S | N0S | n/a | 118910314 | CHEMBL4468645 | (4S,7aR,9aR,10S,11E,15R)-6'-chloro-10-hydroxy-15-methyl-3',4',7a,8,9,9a,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione | n/a | |
| 46 | Q07820_N8J | N8J | n/a | 138376593 | CHEMBL5183445 | (2S)-N-(benzylsulfonyl)-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide | n/a | |
| 47 | Q07820_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 48 | Q07820_NQJ | NQJ | n/a | 138454270 | CHEMBL4560286 | methyl N-(5-{[2-chloro-5-(trifluoromethyl)phenyl]sulfamoyl}-4-methylthiophene-2-carbonyl)-D-phenylalaninate | n/a | |
| 49 | Q07820_OJT | OJT | n/a | 154815660 | CHEMBL4755111 | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-(2-methoxyphenyl)propanoic acid | n/a | |
| 50 | Q07820_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 51 | Q07820_PG6 | PG6 | DB02580 | 70931 | n/a | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE | n/a | |
| 52 | Q07820_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 53 | Q07820_POP | POP | n/a | 4995;18628280;57345951; | n/a | PYROPHOSPHATE 2- | n/a | |
| 54 | Q07820_PZY | PZY | n/a | 145994390 | CHEMBL4576854 | 2-[({4-[(4-tert-butylphenyl)methyl]piperazin-1-yl}sulfonyl)amino]-5-[(2-phenylethyl)sulfanyl]benzoic acid | n/a | |
| 55 | Q07820_Q01 | Q01 | n/a | 122633925 | CHEMBL4525910 | 2-({[4-(4-tert-butylphenyl)piperazin-1-yl]sulfonyl}amino)-5-{[3-oxo-3-(phenylamino)propyl]sulfanyl}benzoic acid | n/a | |
| 56 | Q07820_Q0A | Q0A | n/a | 122622656 | CHEMBL4440719 | 2-[({4-[(4-fluorophenyl)methyl]piperazin-1-yl}sulfonyl)amino]-5-[(2-phenylethyl)sulfanyl]benzoic acid | n/a | |
| 57 | Q07820_Q0D | Q0D | n/a | 122623097 | CHEMBL4457901 | 2-{[(naphthalen-2-yl)sulfonyl]amino}-5-[(2-phenylethyl)sulfanyl]benzoic acid | n/a | |
| 58 | Q07820_Q0G | Q0G | n/a | 122622827 | CHEMBL4475729 | 5-[(2-phenylethyl)sulfanyl]-2-{[(4-phenylpiperazin-1-yl)sulfonyl]amino}benzoic acid | n/a | |
| 59 | Q07820_Q4D | Q4D | n/a | 145704704 | CHEMBL4446369 | (4S,7aR,9aR,10S,11E,18R)-6'-chloro-10-[2-(3,3-difluoroazetidin-1-yl)ethoxy]-N-(dimethylsulfamoyl)-18-hydroxy-15-methyl-16-oxo-3',4',7,7a,8,9,9a,10,13,14,15,16,17,18-tetradecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)cyclobuta[n][1,4]oxazepino[4,3-a][1,8]diazacyclohexadecine-4,1'-naphthalene]-18-carboxamide | n/a | |
| 60 | Q07820_Q4S | Q4S | n/a | 145704705 | CHEMBL4528051 | (4S,7aR,9aR,10S,11E,18R)-6'-chloro-N-(dimethylsulfamoyl)-18-hydroxy-10-methoxy-15-methyl-16-oxo-3',4',7,7a,8,9,9a,10,13,14,15,16,17,18-tetradecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)cyclobuta[n][1,4]oxazepino[4,3-a][1,8]diazacyclohexadecine-4,1'-naphthalene]-18-carboxamide | n/a | |
| 61 | Q07820_Q4V | Q4V | n/a | 145704706 | CHEMBL4542646 | (4S,7aR,9aR,10S,11E,18R)-6'-chloro-10,18-dihydroxy-15-methyl-16-oxo-3',4',7,7a,8,9,9a,10,13,14,15,16,17,18-tetradecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)cyclobuta[n][1,4]oxazepino[4,3-a][1,8]diazacyclohexadecine-4,1'-naphthalene]-18-carboxylic acid | n/a | |
| 62 | Q07820_Q4Y | Q4Y | n/a | 145704707 | CHEMBL4561691 | (4S,11E,17R)-6'-chloro-17-hydroxy-14-methyl-15-oxo-3',4',8,9,10,13,14,15,16,17-decahydro-2'H,3H,5H,7H-spiro[1,18-(ethanediylidene)[1,4]oxazepino[4,3-a][1,8]diazacyclopentadecine-4,1'-naphthalene]-17-carboxylic acid | n/a | |
| 63 | Q07820_Q51 | Q51 | n/a | 118910215 | CHEMBL4476472 | (4S,7aR,9aR,10S,11E,14S,15R)-6'-chloro-10-hydroxy-14,15-dimethyl-3',4',7a,8,9,9a,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione | n/a | |
| 64 | Q07820_Q54 | Q54 | n/a | 145704709 | CHEMBL4515030 | (3S)-6'-chloro-5-(cyclobutylmethyl)-3',4,4',5-tetrahydro-2H,2'H-spiro[1,5-benzoxazepine-3,1'-naphthalene]-7-carboxylic acid | n/a | |
| 65 | Q07820_Q57 | Q57 | n/a | 145704708 | n/a | (2R)-[(3S)-6'-chloro-5-(cyclobutylmethyl)-3',4,4',5-tetrahydro-2H,2'H-spiro[1,5-benzoxazepine-3,1'-naphthalen]-7-yl](hydroxy)acetic acid | n/a | |
| 66 | Q07820_QHR | QHR | n/a | 166625069 | n/a | 7-[3-(isoquinolin-7-yloxymethyl)-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid | n/a | |
| 67 | Q07820_U6N | U6N | n/a | 155094777 | n/a | (2~{R})-2-[[7-but-2-ynyl-5-(3-chloranyl-2-methyl-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid | n/a | |
| 68 | Q07820_U6Q | U6Q | n/a | 155539938 | CHEMBL4515659 | (2~{R})-2-[[5-(3-chloranyl-2-methyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid | n/a | |
| 69 | Q07820_VF8 | VF8 | DB17166 | 118910268 | CHEMBL4446378 | (3R,6R,7S,8E,11S,12R,22S)-6'-chloro-7-methoxy-11,12-dimethyl-13,13-dioxo-spiro[20-oxa-13-gamma6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene-22,1'-tetralin]-15-one | inhibitor | |
| 70 | Q07820_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 71 | Q07820_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a |