Gene name: DDR1
Protein name: Epithelial discoidin domain-containing
List of molecules and drugs that interact with protein Q08345
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q08345_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | n/a | IC50(nM) = 9.4 |
| 2 | Q08345_1IF | 1IF | n/a | 163409957 | n/a | 3-[(6-aminopyridin-3-yl)ethynyl]-N-[3-(trifluoromethyl)phenyl]benzamide | n/a | |
| 3 | Q08345_1IJ | 1IJ | n/a | 163409958 | n/a | N-(2-{3-[(2-aminopyrimidin-5-yl)oxy]phenyl}ethyl)-3-(trifluoromethoxy)benzamide | n/a | |
| 4 | Q08345_1IM | 1IM | n/a | 163409959 | n/a | 2-{3-[(pyridin-3-yl)ethynyl]phenyl}-N-[3-(trifluoromethyl)phenyl]acetamide | n/a | |
| 5 | Q08345_1IW | 1IW | n/a | 24811802 | n/a | 2-chloro-5-{3-chloro-4-[(2-hydroxyethyl)amino]benzamido}-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide | n/a | |
| 6 | Q08345_1IZ | 1IZ | n/a | 163409960 | n/a | N-{[(1R,2S)-2-{2-[(pyridin-3-yl)oxy]ethyl}cyclohexyl]methyl}-3-(trifluoromethoxy)benzamide | n/a | |
| 7 | Q08345_1JI | 1JI | n/a | 163409961 | n/a | 4-chloro-N-[(3S,4R)-4-phenylpyrrolidin-3-yl]-3-{[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide | n/a | |
| 8 | Q08345_1K2 | 1K2 | n/a | 163409962 | n/a | 3-chloro-N-[(1R,2S)-2-phenylcyclopropyl]-5-{[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide | n/a | |
| 9 | Q08345_1N1 | 1N1 | DB01254 | 3062316 | CHEMBL1421 | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | n/a | IC50(nM) = 0.5 Kd(nM) = 0.69 |
| 10 | Q08345_3UI | 3UI | n/a | 117921014 | n/a | N-[(5-chloranyl-2-ethylsulfonyl-phenyl)methyl]-3-piperazin-1-yl-5-(trifluoromethyloxy)benzamide | n/a | |
| 11 | Q08345_4VC | 4VC | n/a | 4426513 | CHEMBL1299308 | 1-(2-chlorophenyl)-3-(pyridin-3-ylmethyl)urea | n/a | |
| 12 | Q08345_4VD | 4VD | n/a | 86764579 | CHEMBL3608786 | N-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide | n/a | |
| 13 | Q08345_4VE | 4VE | n/a | 86763813 | CHEMBL3608791 | N-(5-{(1S)-1-[(5-fluoro-1,3-benzoxazol-2-yl)amino]ethyl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide | n/a | |
| 14 | Q08345_5WR | 5WR | n/a | 119081684 | CHEMBL4453539 | (4~{S})-4-methyl-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1~{H}-isoquinoline-7-carboxamide | n/a | |
| 15 | Q08345_5X1 | 5X1 | n/a | 122197565 | CHEMBL4088388 | 3-[(4-methylpiperazin-1-yl)methyl]-~{N}-[(4~{R})-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1~{H}-isoquinolin-7-yl]-5-(trifluoromethyl)benzamide | n/a | |
| 16 | Q08345_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 17 | Q08345_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 18 | Q08345_D6W | D6W | n/a | 134540391 | CHEMBL4646682 | 2-[8-(2~{H}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{N}-methyl-ethanamide | n/a | |
| 19 | Q08345_D6Z | D6Z | n/a | 130301864 | CHEMBL4635278 | 2-[4-bromanyl-2-oxidanylidene-1'-(1~{H}-pyrazolo[4,3-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | n/a | |
| 20 | Q08345_DI1 | DI1 | n/a | 72836888 | CHEMBL3421914 | 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide | n/a | |
| 21 | Q08345_DJH | DJH | n/a | 130301863 | n/a | 2-[1'-(1~{H}-indazol-5-ylcarbonyl)-4-methyl-2-oxidanylidene-spiro[indole-3,4'-piperidine]-1-yl]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | n/a | |
| 22 | Q08345_DJQ | DJQ | n/a | 124185620 | n/a | 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1~{H}-indazol-5-ylcarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | n/a | |
| 23 | Q08345_DJW | DJW | n/a | 130301889 | n/a | 1-(1~{H}-indazol-5-ylcarbonyl)-5'-methoxy-1'-[2-oxidanylidene-2-[(2~{S})-2-(trifluoromethyl)pyrrolidin-1-yl]ethyl]spiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-2'-one | n/a | |
| 24 | Q08345_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 25 | Q08345_FEW | FEW | n/a | 134693894 | CHEMBL4168305 | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | n/a | |
| 26 | Q08345_GKB | GKB | n/a | 137321210 | CHEMBL4558430 | (2~{R})-~{N}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{H}-indene-5-carboxamide | n/a | |
| 27 | Q08345_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 28 | Q08345_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 29 | Q08345_MLI | MLI | DB02201 | 9084 | n/a | MALONATE ION | n/a | |
| 30 | Q08345_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 31 | Q08345_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 32 | Q08345_NO3 | NO3 | DB14049 | 943 | CHEMBL186200 | NITRATE ION | n/a | |
| 33 | Q08345_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 34 | Q08345_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 35 | Q08345_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 36 | Q08345_TBK | TBK | n/a | 155803658 | n/a | ~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{S})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide | n/a | |
| 37 | Q08345_TJW | TJW | n/a | 155803663 | CHEMBL5081039 | 5-amino-N-(4-(((2S)-4-cyclohexyl-1-((1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)-1-phenyl-1H-pyrazole-4-carboxamide | n/a | |
| 38 | Q08345_VX6 | VX6 | n/a | 5494449 | CHEMBL572878 | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE | n/a | |
| 39 | Q08345_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 40 | Q08345_STI | STI | DB00619 | 5291 | CHEMBL941 | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | antagonist | IC50(nM) = 43.0 Kd(nM) = 0.7 |
| 41 | Q08345_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 42 | Q08345_Q4J | Q4J | DB15822 | n/a | CHEMBL4297597 | Pralsetinib | inhibitor |