Gene name: ITK
Protein name: Tyrosine-protein kinase ITK/TSK
List of molecules and drugs that interact with protein Q08881
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q08881_0F2 | 0F2 | n/a | 135566610 | CHEMBL2017554 | 3-[4-(2-morpholin-4-ylethoxy)-2-(1~{H}-thieno[3,2-c]pyrazol-3-yl)-1~{H}-indol-6-yl]pentan-3-ol | n/a | |
| 2 | Q08881_0G1 | 0G1 | n/a | 135566611 | CHEMBL2017555 | 3-[3-(4-methoxyphenyl)-2-(1H-thieno[3,2-c]pyrazol-3-yl)-1H-indol-6-yl]pentan-3-ol | n/a | |
| 3 | Q08881_0G2 | 0G2 | n/a | 135566613 | CHEMBL2017557 | 3-[2-(5-phenyl-2H-thieno[3,2-c]pyrazol-3-yl)-1H-indol-6-yl]pentan-3-ol | n/a | |
| 4 | Q08881_13J | 13J | n/a | 72200987 | n/a | 3-{4-amino-1-[(3S)-1-propanoylpiperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(propan-2-yl)phenyl]benzamide | n/a | |
| 5 | Q08881_13L | 13L | n/a | 72200986 | n/a | 3-{4-amino-1-[(3R)-1-propanoylpiperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(propan-2-yl)phenyl]benzamide | n/a | |
| 6 | Q08881_18R | 18R | n/a | 72200985 | n/a | 3-{1-[(3R)-1-acryloylpiperidin-3-yl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-(3-tert-butylphenyl)benzamide | n/a | |
| 7 | Q08881_1E0 | 1E0 | n/a | 73386654 | n/a | 4-(carbamoylamino)-1-(7-propoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide | n/a | |
| 8 | Q08881_1YZ | 1YZ | n/a | 73386653 | n/a | 4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide | n/a | |
| 9 | Q08881_29Y | 29Y | n/a | 71777717 | CHEMBL3086536 | (1S,2S)-2-{4-[(dimethylamino)methyl]phenyl}-N-[6-(1H-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | n/a | |
| 10 | Q08881_29Z | 29Z | n/a | 71777716 | CHEMBL3086534 | (1S,2S)-2-{4-[(dimethylamino)methyl]phenyl}-N-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | n/a | |
| 11 | Q08881_2VT | 2VT | n/a | 3722581 | CHEMBL3262780 | N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-2H-indazole-3-carboxamide | n/a | |
| 12 | Q08881_2VU | 2VU | n/a | 71267243 | CHEMBL3263036 | N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide | n/a | |
| 13 | Q08881_2VV | 2VV | n/a | 71259491 | CHEMBL3263053 | N-{1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide | n/a | |
| 14 | Q08881_2VW | 2VW | n/a | 71259555 | CHEMBL3263052 | N-{1-[(1R)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide | n/a | |
| 15 | Q08881_2W6 | 2W6 | n/a | 74983355 | CHEMBL3298371 | N-{1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide | n/a | |
| 16 | Q08881_30T | 30T | n/a | n/a | CHEMBL3355730 | trans-4-({6-[(5-phenyl-1H-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | n/a | |
| 17 | Q08881_3P6 | 3P6 | n/a | 91754231 | CHEMBL3426309 | (4aS,5aR)-N-{1-[(R)-[(2R)-1,1-dioxidotetrahydro-2H-thiopyran-2-yl](phenyl)methyl]-1H-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide | n/a | |
| 18 | Q08881_477 | 477 | n/a | 135566612 | CHEMBL2017556 | 3-{2-[5-(difluoromethyl)-2H-thieno[3,2-c]pyrazol-3-yl]-1H-indol-6-yl}pentan-3-ol | n/a | |
| 19 | Q08881_614 | 614 | n/a | 46174168 | n/a | 7-[(4-methylpiperazin-1-yl)methyl]-4-[(3-methyl-1H-pyrazol-5-yl)amino]-2-(tetrahydro-2H-pyran-4-yl)phthalazin-1(2H)-one | n/a | |
| 20 | Q08881_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 21 | Q08881_B49 | B49 | DB01268 | 5329102 | CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide | n/a | Kd(nM) = 13.0 |
| 22 | Q08881_G5K | G5K | n/a | 56940984 | n/a | 1-[(3S)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | n/a | |
| 23 | Q08881_G6K | G6K | n/a | 71660644 | n/a | 1-[(3S)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | n/a | |
| 24 | Q08881_G7K | G7K | n/a | n/a | CHEMBL2441285 | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | n/a | |
| 25 | Q08881_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 26 | Q08881_IAQ | IAQ | n/a | 72200602 | n/a | (2Z)-4-(dimethylamino)-N-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-N-methylbut-2-enamide | n/a | |
| 27 | Q08881_L7A | L7A | n/a | 11623444 | CHEMBL1738828 | N-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | n/a | |
| 28 | Q08881_L7O | L7O | n/a | 52936531 | CHEMBL1738829 | N-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | n/a | |
| 29 | Q08881_M0Y | M0Y | n/a | 73386651 | n/a | 4-(carbamoylamino)-1-(naphthalen-1-yl)-1H-pyrazole-3-carboxamide | n/a | |
| 30 | Q08881_M0Z | M0Z | n/a | 73386652 | n/a | 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide | n/a | |
| 31 | Q08881_MJG | MJG | n/a | 46174169 | n/a | N-[5-({5-[(4-acetylpiperazin-1-yl)carbonyl]-4-methoxy-2-methylphenyl}sulfanyl)-1,3-thiazol-2-yl]-4-({[(1S)-1,2,2-trimethylpropyl]amino}methyl)benzamide | n/a | |
| 32 | Q08881_P4G | P4G | DB08357 | 8179 | CHEMBL1235106 | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE | n/a | |
| 33 | Q08881_PQC | PQC | n/a | 53245699 | n/a | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | n/a | |
| 34 | Q08881_QWS | QWS | n/a | 73386655 | CHEMBL5169921 | 4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1H-pyrazole-3-carboxamide | n/a | |
| 35 | Q08881_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 36 | Q08881_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 37 | Q08881_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 38 | Q08881_DB06589 | n/a | DB06589 | n/a | n/a | Pazopanib | inhibitor | Kd(nM) = 10000.0 |
| 39 | Q08881_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 40 | Q08881_DB15035 | n/a | DB15035 | n/a | n/a | Zanubrutinib | inhibitor |