Gene name: ROCK1
Protein name: Rho-associated protein kinase
List of molecules and drugs that interact with protein Q13464
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q13464_07Q | 07Q | n/a | 56603818 | CHEMBL3218282 | 1-[(1R)-1-(3-methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea | n/a | |
| 2 | Q13464_07R | 07R | n/a | 60138149 | CHEMBL3218011 | 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea | n/a | |
| 3 | Q13464_0HD | 0HD | n/a | 56596554 | CHEMBL2023154 | 1-(1H-indazol-5-yl)-3-(2-phenylethyl)urea | n/a | |
| 4 | Q13464_3J7 | 3J7 | n/a | 78673872 | CHEMBL3338838 | N~1~-[2-(1H-indazol-5-yl)pyrido[3,4-d]pyrimidin-4-yl]-2-methylpropane-1,2-diamine | n/a | |
| 5 | Q13464_3NC | 3NC | n/a | n/a | CHEMBL1222571 | cis-4-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamide | n/a | |
| 6 | Q13464_3ND | 3ND | n/a | 49866493 | n/a | (3S,4R)-N-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide | n/a | |
| 7 | Q13464_4KH | 4KH | n/a | 10402473 | CHEMBL3581115 | 2-fluoro-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]benzamide | n/a | |
| 8 | Q13464_4KK | 4KK | n/a | 4803142 | CHEMBL3581121 | 2-(3-methoxyphenyl)-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide | n/a | |
| 9 | Q13464_4TW | 4TW | n/a | 24830571 | CHEMBL3580669 | N-[4-(2-fluoropyridin-4-yl)thiophen-2-yl]-2-{3-[(methylsulfonyl)amino]phenyl}acetamide | n/a | |
| 10 | Q13464_65R | 65R | n/a | 60097413 | CHEMBL4251324 | 2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide | n/a | |
| 11 | Q13464_6U1 | 6U1 | n/a | 11690457 | CHEMBL4249925 | 2-[3-(methylsulfonylamino)phenyl]-~{N}-[4-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide | n/a | |
| 12 | Q13464_6U2 | 6U2 | n/a | 11705863 | CHEMBL4248525 | 2-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-~{N}-[4-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide | n/a | |
| 13 | Q13464_86G | 86G | n/a | 154877121 | n/a | 2-[3-(methoxymethyl)phenyl]-N-[4-(1H-pyrazol-4-yl)phenyl]acetamide | n/a | |
| 14 | Q13464_86K | 86K | n/a | 48418665 | n/a | 2-[methyl(phenyl)amino]-1-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydropyridin-1(2H)-yl]ethan-1-one | n/a | |
| 15 | Q13464_8UV | 8UV | n/a | 24832012 | CHEMBL3581140 | N-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide | n/a | |
| 16 | Q13464_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 17 | Q13464_B4J | B4J | n/a | 25056372 | n/a | 3,4-dimethoxy-N-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamide | n/a | |
| 18 | Q13464_B4V | B4V | n/a | 84973047 | CHEMBL3680720 | 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)-1H-1,2,3-triazole-4-carboxamide | n/a | |
| 19 | Q13464_B4Y | B4Y | n/a | 88591173 | CHEMBL3700932 | (2R)-N-(3-cyanophenyl)-2-(3-{[(6S)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide | n/a | |
| 20 | Q13464_B5G | B5G | n/a | 87091884 | CHEMBL3700973 | (2R)-N-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamide | n/a | |
| 21 | Q13464_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 22 | Q13464_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 23 | Q13464_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 24 | Q13464_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 25 | Q13464_H52 | H52 | DB07876 | 448043 | CHEMBL406821 | (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE | inhibitor | Ki(nM) = 6.0 IC50(nM) = 5.0 |
| 26 | Q13464_HFS | HFS | DB04707 | 3064778 | CHEMBL1233300 | 1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE | inhibitor | Ki(nM) = 150.0 IC50(nM) = 720.0 |
| 27 | Q13464_J0P | J0P | n/a | 134823958 | CHEMBL4522042 | N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide | n/a | |
| 28 | Q13464_M77 | M77 | DB08162 | 3547 | CHEMBL38380 | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE | inhibitor | Ki(nM) = 100.0 IC50(nM) = 180.0 Kd(nM) = 50.0 |
| 29 | Q13464_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 30 | Q13464_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 31 | Q13464_VFS | VFS | n/a | 85469696 | CHEMBL3955445 | N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide | n/a | |
| 32 | Q13464_Y27 | Y27 | DB08756 | n/a | CHEMBL559147 | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE | n/a | Ki(nM) = 25.12 IC50(nM) = 46.0 |
| 33 | Q13464_DB13165 | n/a | DB13165 | n/a | n/a | Ripasudil | inhibitor | |
| 34 | Q13464_DB13931 | n/a | DB13931 | n/a | n/a | Netarsudil | inhibitor | |
| 35 | Q13464_ICQ | ICQ | DB16703 | 11950170 | CHEMBL2005186 | Belumosudil | inhibitor |