Gene name: DYRK1A
Protein name: Dual specificity tyrosine-phosphorylation-regulated
List of molecules and drugs that interact with protein Q13627
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q13627_1PE | 1PE | n/a | 62551 | CHEMBL1229766 | PENTAETHYLENE GLYCOL | n/a | |
| 2 | Q13627_2C3 | 2C3 | n/a | 72193919 | n/a | N-(5-{[(1R)-3-amino-1-(3-chlorophenyl)propyl]carbamoyl}-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | n/a | |
| 3 | Q13627_2C4 | 2C4 | n/a | 57524821 | CHEMBL3094442 | methyl 4-chloro-3-{[(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)carbonyl]amino}benzoate | n/a | |
| 4 | Q13627_2K2 | 2K2 | DB06595 | 9829523 | CHEMBL608533 | PKC412 | n/a | |
| 5 | Q13627_39I | 39I | n/a | 49830886 | CHEMBL1997924 | ~{N}4-(3-cyclopropyl-1~{H}-pyrazol-5-yl)-~{N}2-(phenylmethyl)thieno[3,2-d]pyrimidine-2,4-diamine | n/a | |
| 6 | Q13627_3NG | 3NG | DB15408 | 24748573 | CHEMBL1230165 | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | n/a | |
| 7 | Q13627_3RA | 3RA | n/a | 51346199;135566559; | CHEMBL1738733 | 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one | n/a | |
| 8 | Q13627_4E1 | 4E1 | n/a | 91664021 | CHEMBL3589662 | 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid | n/a | |
| 9 | Q13627_4E2 | 4E2 | n/a | 91664022 | CHEMBL3589671 | 10-chloro-2-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid | n/a | |
| 10 | Q13627_4E3 | 4E3 | n/a | 91664023 | CHEMBL3589672 | 10-bromo-2-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid | n/a | |
| 11 | Q13627_4H5 | 4H5 | n/a | 91664024 | CHEMBL4283240 | (1-chloro-7-methoxy-9H-beta-carbolin-9-yl)acetonitrile | n/a | |
| 12 | Q13627_4VZ | 4VZ | n/a | 1389487 | CHEMBL5188976 | (5~{Z})-5-[(3-ethoxy-4-oxidanyl-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | n/a | |
| 13 | Q13627_4WD | 4WD | n/a | 162679104 | n/a | (5~{Z})-5-[(3-ethynyl-4-methoxy-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | n/a | |
| 14 | Q13627_5PW | 5PW | n/a | 731719 | CHEMBL1213041 | N-(6-nitro-1,3-benzothiazol-2-yl)ethanamide | n/a | |
| 15 | Q13627_6SD | 6SD | n/a | 2756469 | CHEMBL3751985 | 3-(4-methoxyphenyl)-1~{H}-pyrazol-5-amine | n/a | |
| 16 | Q13627_6ZV | 6ZV | DB12001 | 46220502 | CHEMBL3301610 | N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine | n/a | |
| 17 | Q13627_7QQ | 7QQ | n/a | 655817 | CHEMBL1532203 | N-(5-methoxy-1,3-benzothiazol-2-yl)ethanamide | n/a | |
| 18 | Q13627_9OF | 9OF | n/a | 134817498 | CHEMBL4741586 | 8-methoxy-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine | n/a | |
| 19 | Q13627_9OL | 9OL | n/a | 134817499 | CHEMBL4755730 | 5,5-dimethyl-8-[1-(piperidin-4-yl)ethenyl]-5,6-dihydrobenzo[h]quinazolin-4-amine | n/a | |
| 20 | Q13627_AJG | AJG | n/a | 121225571 | CHEMBL4759909 | N-(6-CYANO-3H-1,3-BENZOTHIAZOL-2-YLIDENE)ETHANAMIDE | n/a | |
| 21 | Q13627_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 22 | Q13627_AWR | AWR | n/a | 54613080 | CHEMBL2012574 | 4-(7-METHOXY-1-(TRIFLUOROMETHYL)-9H-PYRIDO[3,4-B]INDOL-9-yl)butan-1-amine | n/a | |
| 23 | Q13627_B5T | B5T | n/a | 134812697 | CHEMBL4164814 | 4-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide | n/a | |
| 24 | Q13627_B5Z | B5Z | n/a | 49838747 | CHEMBL4171209 | ~{N}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino)phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide | n/a | |
| 25 | Q13627_B6B | B6B | n/a | 134812698 | CHEMBL4167484 | [3-azanyl-6-(5-azanyl-2-methoxy-phenyl)pyrazin-2-yl]-pyridin-3-yl-methanone | n/a | |
| 26 | Q13627_B6H | B6H | n/a | 134812700 | n/a | ~{N}-[4-[[4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide | n/a | |
| 27 | Q13627_B6N | B6N | n/a | 51351159 | CHEMBL1765714 | 1-[4-fluoranyl-2-(trifluoromethyl)phenyl]-9-(1~{H}-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2-one | n/a | |
| 28 | Q13627_B6Q | B6Q | n/a | 134812701 | n/a | ~{N}-[3-[[4-azanyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide | n/a | |
| 29 | Q13627_B6Z | B6Z | n/a | 134812699 | CHEMBL4171089 | [4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]-phenyl-methanone | n/a | |
| 30 | Q13627_B7B | B7B | n/a | 68034378 | CHEMBL3986079 | 4-[[(3~{R},7~{S})-2-cyclopentyl-9-methyl-8-oxidanylidene-2,9,12,14-tetrazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),10,12-trien-13-yl]amino]benzamide | n/a | |
| 31 | Q13627_B7W | B7W | n/a | 60155996 | CHEMBL2152265 | 3-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)aniline | n/a | |
| 32 | Q13627_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 33 | Q13627_D15 | D15 | DB07608 | 24894158 | n/a | N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide | n/a | |
| 34 | Q13627_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 35 | Q13627_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 36 | Q13627_EHB | EHB | n/a | 44136031 | CHEMBL1232500 | (1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)propan-2-one | n/a | |
| 37 | Q13627_EKU | EKU | n/a | 5281626 | CHEMBL184574 | 1,3,5,8-tetrakis(oxidanyl)xanthen-9-one | n/a | |
| 38 | Q13627_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 39 | Q13627_FLC | FLC | n/a | 31348 | n/a | CITRATE ANION | n/a | |
| 40 | Q13627_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 41 | Q13627_HRM | HRM | DB07919 | 5280953 | CHEMBL269538 | 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE | inhibitor | Ki(nM) = 33.0 IC50(nM) = 8.8 Kd(nM) = 5.5 |
| 42 | Q13627_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 43 | Q13627_IWU | IWU | n/a | 494193 | CHEMBL5206363 | 6-bromanyl-3H-[1,2,3]triazolo[4,5-b]pyridine | n/a | |
| 44 | Q13627_JHW | JHW | n/a | 145997893 | CHEMBL4798624 | 8-cyclopropyl-2-pyridin-3-yl-[1,3]thiazolo[5,4-f]quinazolin-9-one | n/a | |
| 45 | Q13627_KQE | KQE | n/a | 138454301 | n/a | 6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine | n/a | |
| 46 | Q13627_KQK | KQK | n/a | 138454302 | CHEMBL4848254 | ~{N},~{N}-dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine | n/a | |
| 47 | Q13627_KQW | KQW | n/a | 10236275 | CHEMBL4848696 | ~{N}-cyclopropyl-~{N}-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine | n/a | |
| 48 | Q13627_KQZ | KQZ | n/a | 138454304 | CHEMBL4852953 | ~{N},~{N}-dimethyl-4-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine | n/a | |
| 49 | Q13627_KR8 | KR8 | n/a | 6539360 | CHEMBL360866 | ~{N}-methyl-~{N}-phenyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine | n/a | |
| 50 | Q13627_KRK | KRK | n/a | 138454306 | CHEMBL4869255 | 3-[2-[(3~{S})-3-fluoranylpyrrolidin-1-yl]pyrimidin-4-yl]pyrazolo[1,5-b]pyridazine | n/a | |
| 51 | Q13627_KRQ | KRQ | n/a | 138454303 | CHEMBL4581461 | ~{N}-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine | n/a | |
| 52 | Q13627_LI | LI | n/a | 28486 | CHEMBL1234004 | LITHIUM ION | n/a | |
| 53 | Q13627_MFR | MFR | DB08178 | 23727981 | CHEMBL270686 | 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine | n/a | |
| 54 | Q13627_MLW | MLW | n/a | 145704692 | CHEMBL5186380 | 4-chloranyl-5~{H}-cyclohepta[b]indol-10-one | n/a | |
| 55 | Q13627_OPW | OPW | n/a | 134434352 | CHEMBL5288595 | ~{N}-[5-(5-methoxy-1,3-benzothiazol-2-yl)pyridin-3-yl]ethanamide | n/a | |
| 56 | Q13627_P6G | P6G | n/a | 17472 | CHEMBL1235082 | HEXAETHYLENE GLYCOL | n/a | |
| 57 | Q13627_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 58 | Q13627_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 59 | Q13627_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 60 | Q13627_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 61 | Q13627_Q8J | Q8J | n/a | 145994392 | CHEMBL4636064 | 4-ethyl-N-{4-[1-(oxan-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl}piperazine-1-carboxamide | n/a | |
| 62 | Q13627_QIV | QIV | n/a | 118295558 | CHEMBL4747967 | N-(5-oxidanyl-1,3-benzothiazol-2-yl)ethanamide | n/a | |
| 63 | Q13627_QKG | QKG | n/a | 139520309 | CHEMBL4474836 | 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide | n/a | |
| 64 | Q13627_QY8 | QY8 | n/a | 96253;135408714; | CHEMBL41044 | 2-amino-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one | n/a | |
| 65 | Q13627_QYB | QYB | n/a | 22418700;135992006; | CHEMBL2432026 | 3-phenyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 66 | Q13627_QYE | QYE | n/a | 130814982 | CHEMBL5089793 | 7-chlorothieno[3,2-c]pyridin-4-amine | n/a | |
| 67 | Q13627_QYH | QYH | n/a | 2808121 | CHEMBL2023701 | 6-(4-methoxyphenyl)pyrimidine-2,4-diamine | n/a | |
| 68 | Q13627_QYK | QYK | n/a | 10682212 | CHEMBL5081135 | 4-azanyl-6-bromanyl-7-methyl-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 69 | Q13627_QYW | QYW | n/a | 155926548 | CHEMBL5091344 | 4-azanyl-2-methyl-6-pyridin-3-yl-7~{H}-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | n/a | |
| 70 | Q13627_QYZ | QYZ | n/a | 2358462 | CHEMBL89697 | (3~{E})-3-[(5-methylfuran-2-yl)methylidene]-1~{H}-indol-2-one | n/a | |
| 71 | Q13627_QZ2 | QZ2 | n/a | 3161119 | CHEMBL5071361 | 3-(1-methylpyrazol-4-yl)-1~{H}-pyrazole-5-carboxylic acid | n/a | |
| 72 | Q13627_QZW | QZW | n/a | 135336127 | CHEMBL5091510 | 4-[2-methyl-4-(thiophen-3-ylmethoxy)-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]pyridin-2-amine | n/a | |
| 73 | Q13627_R05 | R05 | n/a | 135283800 | CHEMBL5093650 | 5-(2-azanylpyridin-4-yl)-~{N}-[[2,6-bis(fluoranyl)phenyl]methyl]-2-methyl-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 74 | Q13627_RHH | RHH | n/a | 135336101 | CHEMBL5077422 | 4-[2-methyl-3-(2-pyridin-2-yloxyethyl)imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine | n/a | |
| 75 | Q13627_RHT | RHT | n/a | 155920135 | CHEMBL5083489 | 4-(3-methylbenzimidazol-5-yl)pyridine-2,6-diamine | n/a | |
| 76 | Q13627_RHW | RHW | n/a | 155920134 | CHEMBL5092362 | 4-(1-benzofuran-5-yl)pyridine-2,6-diamine | n/a | |
| 77 | Q13627_RHZ | RHZ | n/a | 104877339 | CHEMBL5078346 | 4-(4-chloranyl-3-methoxy-phenyl)pyridin-2-amine | n/a | |
| 78 | Q13627_RJ2 | RJ2 | n/a | 155920137 | CHEMBL5085033 | 1-[4-(1-benzofuran-5-yl)pyridin-2-yl]piperazine | n/a | |
| 79 | Q13627_RJ5 | RJ5 | n/a | 82397500 | CHEMBL5075137 | 4-(4-methoxyphenyl)pyridin-2-amine | n/a | |
| 80 | Q13627_RJ8 | RJ8 | n/a | 155920136 | CHEMBL5083053 | 4-(1-benzofuran-5-yl)pyridin-2-amine | n/a | |
| 81 | Q13627_RJZ | RJZ | n/a | 135335953 | CHEMBL5089171 | 4-[3-[2-(6-bromanylpyridin-2-yl)oxyethyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine | n/a | |
| 82 | Q13627_RK2 | RK2 | n/a | 135336092 | CHEMBL5092833 | 4-[2-methyl-3-[(2~{R})-2-pyridin-2-yloxypropyl]imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine | n/a | |
| 83 | Q13627_RK5 | RK5 | n/a | 155920140 | CHEMBL5073869 | 4-(2,3-dimethyl-1-benzofuran-5-yl)pyridine-2,6-diamine | n/a | |
| 84 | Q13627_RK8 | RK8 | n/a | 141518168 | n/a | 4-[3-[(2~{S})-2-(6-bromanylpyridin-2-yl)oxypropyl]-2-methyl-imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine | n/a | |
| 85 | Q13627_RKH | RKH | n/a | 155920139 | CHEMBL5094822 | 4-(2-methyl-1-benzofuran-5-yl)pyridine-2,6-diamine | n/a | |
| 86 | Q13627_RKK | RKK | n/a | 135335840 | CHEMBL5091644 | 4-(2,3-dibutylimidazo[4,5-b]pyridin-5-yl)pyridine-2,6-diamine | n/a | |
| 87 | Q13627_RKQ | RKQ | n/a | 135335939 | CHEMBL5088511 | 4-[2-methyl-3-(2-phenoxyethyl)imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine | n/a | |
| 88 | Q13627_RKW | RKW | n/a | 155920138 | CHEMBL5070119 | ~{N}-[6-azanyl-4-(1-benzofuran-5-yl)pyridin-2-yl]-2-(methylamino)ethanamide | n/a | |
| 89 | Q13627_RKZ | RKZ | n/a | 135335801 | CHEMBL4575900 | 4-[2-methyl-3-[(2~{R})-2-phenoxypropyl]imidazo[4,5-b]pyridin-5-yl]pyridine-2,6-diamine | n/a | |
| 90 | Q13627_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 91 | Q13627_Y3L | Y3L | n/a | 959639 | CHEMBL4556783 | N-(5-CHLORANYL-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE | n/a | |
| 92 | Q13627_ZC3 | ZC3 | n/a | 121225570 | CHEMBL4754469 | N-(5-FLUORANYL-1,3-BENZOTHIAZOL-2-YL)ETHANAMIDE | n/a | |
| 93 | Q13627_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |