Gene name: KEAP1
Protein name: Kelch-like ECH-associated protein
List of molecules and drugs that interact with protein Q14145
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q14145_08A | 08A | n/a | 135263899 | CHEMBL4635041 | (3S)-3-[2-(benzenecarbonyl)-5-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl]-3-(1-ethyl-4-methyl-1H-benzotriazol-5-yl)propanoic acid | n/a | |
| 2 | Q14145_12O | 12O | n/a | 72201006 | CHEMBL2381966 | (1R,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid | n/a | |
| 3 | Q14145_1VV | 1VV | n/a | 56840728 | CHEMBL2381968 | (1S,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid | n/a | |
| 4 | Q14145_1VW | 1VW | n/a | 72771091 | CHEMBL4167472 | 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione | n/a | |
| 5 | Q14145_1VX | 1VX | n/a | 72771092 | CHEMBL3890847 | (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid | n/a | |
| 6 | Q14145_1XM | 1XM | n/a | 90253;1268262;135408756; | CHEMBL4436742 | 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione | n/a | |
| 7 | Q14145_2FS | 2FS | n/a | 72771096 | CHEMBL4167678 | (1S,2R)-2-{[(1S)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid | n/a | |
| 8 | Q14145_41P | 41P | n/a | 91885637 | CHEMBL3632711 | 2,2'-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetamide | n/a | |
| 9 | Q14145_4ID | 4ID | n/a | 50744391 | CHEMBL2402206 | 2-({5-[(2,4-dimethylphenyl)sulfonyl]-6-oxo-1,6-dihydropyrimidin-2-yl}sulfanyl)-N-[2-(trifluoromethyl)phenyl]acetamide | n/a | |
| 10 | Q14145_58E | 58E | n/a | 137348321 | n/a | (5aS,6S,9aS)-7-hydroxy-2,6,9a-trimethyl-3-(pyridin-3-yl)-4,5,5a,6,9,9a-hexahydro-2H-benzo[g]indazole-8-carbonitrile | n/a | |
| 11 | Q14145_8ZL | 8ZL | n/a | 162678567 | CHEMBL5080665 | (5S,8R)-N,N-dimethyl-8-[[(2S)-1-[4-(methylamino)-4-oxidanylidene-butanoyl]pyrrolidin-2-yl]carbonylamino]-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(12),13,15-triene-5-carboxamide | n/a | |
| 12 | Q14145_91M | 91M | n/a | 162678568 | CHEMBL5082765 | (5S,8R)-16-(2,1,3-benzoxadiazol-4-yl)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-N,N-dimethyl-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-5-carboxamide | n/a | |
| 13 | Q14145_92I | 92I | n/a | 162678566 | n/a | (3S,5S,8R)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-N,N-dimethyl-3,7,11-tris(oxidanylidene)-10-oxa-3$l^{4}-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-5-carboxamide | n/a | |
| 14 | Q14145_9HB | 9HB | n/a | 7820 | CHEMBL556489 | Dimethyl fumarate | n/a | |
| 15 | Q14145_9IB | 9IB | n/a | 162678569 | CHEMBL5090388 | 3-[(5S,8R)-5-(dimethylcarbamoyl)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-trien-16-yl]benzoic acid | n/a | |
| 16 | Q14145_9J3 | 9J3 | n/a | 70610 | n/a | 4-ethoxy-4-oxobutanoic acid | n/a | |
| 17 | Q14145_9P0 | 9P0 | n/a | 162678570 | CHEMBL5092602 | 4-[(5S,8R)-5-(dimethylcarbamoyl)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-trien-16-yl]benzoic acid | n/a | |
| 18 | Q14145_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 19 | Q14145_AO7 | AO7 | n/a | 2741 | CHEMBL83628 | 4-oxo-4H-1-benzopyran-2-carboxylic acid | n/a | |
| 20 | Q14145_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 21 | Q14145_D8N | D8N | n/a | 137349164 | n/a | ~{N}-[4-[(5~{R})-4,5-dihydro-1,2-oxazol-5-yl]phenyl]ethanamide | n/a | |
| 22 | Q14145_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 23 | Q14145_DTD | DTD | DB01822 | 439407 | n/a | DITHIANE DIOL | n/a | |
| 24 | Q14145_DTT | DTT | DB04447 | 439196 | CHEMBL406270 | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | n/a | |
| 25 | Q14145_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 26 | Q14145_EOU | EOU | DB08908 | 637568 | CHEMBL2107333 | dimethyl (~{E})-but-2-enedioate | binder | |
| 27 | Q14145_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 28 | Q14145_FUU | FUU | n/a | 70680427 | CHEMBL4576082 | 2-(3-((3-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)ureido)methyl)phenoxy)acetic acid | n/a | |
| 29 | Q14145_GCI | GCI | n/a | 164513527 | CHEMBL5186985 | N-[4-[(2-azanyl-2-oxidanylidene-ethyl)-[4-[(2-azanyl-2-oxidanylidene-ethyl)-(4-methoxyphenyl)sulfonyl-amino]naphthalen-1-yl]sulfamoyl]phenyl]-3-morpholin-4-yl-propanamide | n/a | |
| 30 | Q14145_GDJ | GDJ | n/a | 164575886 | CHEMBL5184256 | N-[4-[(2-azanyl-2-oxidanylidene-ethyl)-[4-[(2-azanyl-2-oxidanylidene-ethyl)-(4-methoxyphenyl)sulfonyl-amino]naphthalen-1-yl]sulfamoyl]phenyl]-2-(4-ethylpiperazin-1-yl)ethanamide | n/a | |
| 31 | Q14145_GED | GED | n/a | 164517143 | CHEMBL5185586 | N-[4-[(2-azanyl-2-oxidanylidene-ethyl)-[4-[(2-azanyl-2-oxidanylidene-ethyl)-(4-methoxyphenyl)sulfonyl-amino]naphthalen-1-yl]sulfamoyl]phenyl]-3-(4-ethylpiperazin-1-yl)propanamide | n/a | |
| 32 | Q14145_GFD | GFD | n/a | 164513524 | CHEMBL4856564 | 2-[(4-aminophenyl)sulfonyl-[4-[(2-azanyl-2-oxidanylidene-ethyl)-(4-methoxyphenyl)sulfonyl-amino]naphthalen-1-yl]amino]ethanamide | n/a | |
| 33 | Q14145_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 34 | Q14145_GX8 | GX8 | n/a | 139582005 | CHEMBL5172581 | 2-[[4-[2-hydroxy-2-oxoethyl-(4-methoxyphenyl)sulfonyl-amino]-3-phenylmethoxy-phenyl]-(4-methoxyphenyl)sulfonyl-amino]ethanoic acid | n/a | |
| 35 | Q14145_HB6 | HB6 | n/a | 168008973 | n/a | 2-[[4-[(2-azanyl-2-oxidanylidene-ethyl)-(4-methoxyphenyl)sulfonyl-amino]naphthalen-1-yl]-[4-(2-diethoxyphosphorylethanoylamino)phenyl]sulfonyl-amino]ethanamide | n/a | |
| 36 | Q14145_HPP | HPP | DB03897 | 10394 | CHEMBL1172560 | HYDROXYPHENYL PROPIONIC ACID | n/a | |
| 37 | Q14145_IQK | IQK | n/a | 1073725 | CHEMBL2402207 | N,N'-naphthalene-1,4-diylbis(4-methoxybenzenesulfonamide) | n/a | |
| 38 | Q14145_LQ8 | LQ8 | n/a | 146048118 | CHEMBL4636738 | (1~{S},2~{R})-2-[[(1~{S})-1-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-5-(2-hydroxyethyloxy)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]cyclohexane-1-carboxylic acid | n/a | |
| 39 | Q14145_LQK | LQK | n/a | 146048119 | CHEMBL4648717 | (1~{S},2~{R})-2-[[(1~{S})-1-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-5-(2-hydroxyethyloxy)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]cyclobutane-1-carboxamide | n/a | |
| 40 | Q14145_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 41 | Q14145_PG5 | PG5 | DB02078 | 8189 | CHEMBL1235255 | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE | n/a | |
| 42 | Q14145_PKG | PKG | n/a | 135263934 | CHEMBL4642419 | (3S)-3-[2-(benzenecarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-3-(1-ethyl-4-methyl-1H-benzotriazol-5-yl)propanoic acid | n/a | |
| 43 | Q14145_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 44 | Q14145_Q5V | Q5V | n/a | 139570943 | CHEMBL4646536 | N-[(4-methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl](2,2,2-trifluoroethyl)amino}isoquinolin-1-yl)glycine | n/a | |
| 45 | Q14145_Q5Y | Q5Y | n/a | 77461035 | CHEMBL3617852 | N-[(4-methoxyphenyl)sulfonyl]-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}naphthalen-1-yl)glycine | n/a | |
| 46 | Q14145_Q9E | Q9E | n/a | 155289301 | CHEMBL4757224 | (5S,8R)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-N,N-dimethyl-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-5-carboxamide | n/a | |
| 47 | Q14145_SGO | SGO | n/a | 25577337 | CHEMBL5286485 | (3S)-3-(4-methylphenyl)-3-[2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoylamino]propanoic acid | n/a | |
| 48 | Q14145_SIU | SIU | n/a | 168301052 | CHEMBL5284304 | (2R,3S)-2-methyl-3-(4-methylphenyl)-3-[2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoylamino]propanoic acid | n/a | |
| 49 | Q14145_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 50 | Q14145_TX6 | TX6 | n/a | 137350068 | n/a | (6aS,7S,10aS)-8-hydroxy-4-methoxy-2,7,10a-trimethyl-5,6,6a,7,10,10a-hexahydrobenzo[h]quinazoline-9-carbonitrile | n/a | |
| 51 | Q14145_XXT | XXT | n/a | 14466541 | CHEMBL1165708 | [(3aS,5R,5aS,6S,8S,8aS,9S,9aR)-9-acetyloxy-8-hydroxy-5,8a-dimethyl-1-methylidene-2-oxo-4,5,5a,6,7,8,9,9a-octahydro-3aH-azuleno[6,5-b]furan-6-yl] acetate | n/a | |
| 52 | Q14145_ZK2 | ZK2 | n/a | 6994 | n/a | (2-methylphenyl)methanol | n/a | |
| 53 | Q14145_SXJ | SXJ | n/a | 53345102 | n/a | (13alpha,18alpha)-2-cyano-3-hydroxy-12-oxooleana-2,9(11)-dien-28-oic acid | n/a | |
| 54 | Q14145_T6I | T6I | n/a | 168301053 | CHEMBL5284493 | (2R,3S)-3-[[(2S)-2-fluoranyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanoyl]amino]-2-methyl-3-(4-methylphenyl)propanoic acid | n/a |