Gene name: METTL3
Protein name: N(6)-adenosine-methyltransferase catalytic subunit
List of molecules and drugs that interact with protein Q86U44
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q86U44_0AE | 0AE | n/a | 156621359 | n/a | (3~{R})-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-3-[[[6-[[(3~{S})-3-propan-2-yl-2-azoniaspiro[3.3]heptan-2-yl]methyl]naphthalen-1-yl]amino]methyl]piperidin-3-ol | n/a | |
| 2 | Q86U44_0BA | 0BA | n/a | 156619961 | n/a | 2-oxidanyl-N-[[(3R)-3-oxidanyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]methyl]-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide | n/a | |
| 3 | Q86U44_0BH | 0BH | n/a | 156619962 | n/a | N-[[(3R)-1-[6-(1-benzothiophen-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide | n/a | |
| 4 | Q86U44_6IK | 6IK | n/a | 156621362 | n/a | 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-N-[[(3S)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide | n/a | |
| 5 | Q86U44_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 6 | Q86U44_ADN | ADN | DB00640 | 60961 | CHEMBL477 | ADENOSINE | n/a | IC50(nM) = 495000.0 |
| 7 | Q86U44_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | |
| 8 | Q86U44_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 9 | Q86U44_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 10 | Q86U44_H3I | H3I | n/a | n/a | n/a | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(7~{H}-purin-6-ylcarbamoyl)amino]-2-azanyl-butanoic acid | n/a | |
| 11 | Q86U44_H9D | H9D | n/a | n/a | n/a | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[2-[[9-[(2~{R},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethylamino]methyl]oxolane-3,4-diol | n/a | |
| 12 | Q86U44_HZ2 | HZ2 | n/a | 137552762 | n/a | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid | n/a | |
| 13 | Q86U44_I0C | I0C | n/a | n/a | n/a | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7~{H}-purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid | n/a | |
| 14 | Q86U44_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 15 | Q86U44_NWQ | NWQ | n/a | 98567 | CHEMBL519809 | (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-~{N}-methyl-3,4-bis(oxidanyl)oxolane-2-carboxamide | n/a | |
| 16 | Q86U44_NWW | NWW | n/a | 97692 | CHEMBL4778617 | (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolane-2-carboxamide | n/a | |
| 17 | Q86U44_NWZ | NWZ | n/a | 110145076 | n/a | (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-piperidin-4-yl-oxolane-2-carboxamide | n/a | |
| 18 | Q86U44_NX8 | NX8 | n/a | 110154059 | CHEMBL5281978 | (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-(piperidin-4-ylmethyl)oxolane-2-carboxamide | n/a | |
| 19 | Q86U44_NXB | NXB | n/a | 145994381 | n/a | (2~{R},3~{R},4~{R},5~{R})-2-[(6-aminopurin-9-yl)methyl]-5-azanyl-oxane-3,4-diol | n/a | |
| 20 | Q86U44_QWR | QWR | n/a | 155167515 | CHEMBL5402970 | 2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine | n/a | |
| 21 | Q86U44_R72 | R72 | n/a | 154815692 | CHEMBL5279050 | 4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide | n/a | |
| 22 | Q86U44_SAH | SAH | DB01752 | 439155;25246222; | CHEMBL418052 | S-ADENOSYL-L-HOMOCYSTEINE | n/a | |
| 23 | Q86U44_SAM | SAM | DB00118 | n/a | CHEMBL1235831 | S-ADENOSYLMETHIONINE | n/a | |
| 24 | Q86U44_SFG | SFG | DB01910 | 65482 | CHEMBL1214186 | SINEFUNGIN | n/a | |
| 25 | Q86U44_UDK | UDK | n/a | 156619941 | n/a | (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl)piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl)methyl)benzamide | n/a | |
| 26 | Q86U44_UDQ | UDQ | n/a | 124989424 | n/a | N-[[(3R)-3-Hydroxy-1-[6-(methylamino)pyrimidin-4-yl]piperidin-3-yl]methyl]-4-(piperidin-1-ylmethyl)benzamide | n/a | |
| 27 | Q86U44_UDW | UDW | n/a | 156619942 | n/a | (S)-3-(((6-(3-(hydroxymethyl)piperidin-1-yl)pyrimidin-4-yl)amino)methyl)benzenesulfonamide | n/a | |
| 28 | Q86U44_UE2 | UE2 | n/a | 156587337 | n/a | (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl)piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl)methyl)benzamide | n/a | |
| 29 | Q86U44_UE5 | UE5 | n/a | 156619943 | n/a | (R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)benzamide | n/a | |
| 30 | Q86U44_UEE | UEE | n/a | 156619944 | n/a | (R)-4-((2-azaspiro[3.3]heptan-2-yl)methyl)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)benzamide | n/a | |
| 31 | Q86U44_UEH | UEH | n/a | 156621366 | n/a | (R)-4-((4,4-dimethylpiperidin-1-yl)methyl)-2-hydroxy-N-((3-hydroxy-1-(6-((3-(methylcarbamoyl)benzyl)amino)pyrimidin-4-yl)piperidin-3-yl)methyl)benzamide | n/a | |
| 32 | Q86U44_UEQ | UEQ | n/a | 156619946 | n/a | 4-[[(3R)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-N-[[(3R)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide | n/a | |
| 33 | Q86U44_UEW | UEW | n/a | 156619945 | n/a | N-(((R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-(((S)-1-isopropyl-2-azaspiro[3.3]heptan-2-yl)methyl)benzamide | n/a | |
| 34 | Q86U44_UEZ | UEZ | n/a | 156619947 | n/a | (R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-(((6-((4,4-dimethylpiperidin-1-yl)methyl)naphthalen-1-yl)amino)methyl)piperidin-3-ol | n/a | |
| 35 | Q86U44_UNX | UNX | n/a | |||||
| 36 | Q86U44_UXE | UXE | n/a | 156587339 | CHEMBL5091512 | 4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol | n/a | |
| 37 | Q86U44_UXK | UXK | n/a | 156587340 | CHEMBL5077723 | 6-[4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]-N-(phenylmethyl)pyrimidin-4-amine | n/a | |
| 38 | Q86U44_UXT | UXT | n/a | 156596350 | CHEMBL5087497 | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 39 | Q86U44_UXW | UXW | n/a | 156587341 | CHEMBL5082067 | 4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 40 | Q86U44_UXZ | UXZ | n/a | 156596351 | CHEMBL5084812 | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 41 | Q86U44_UY2 | UY2 | n/a | 156596352 | CHEMBL5083959 | 3-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-8-[6-(methylamino)pyrimidin-4-yl]-1,3,8-triazaspiro[4.5]decan-2-one | n/a | |
| 42 | Q86U44_UY5 | UY5 | n/a | 156596353 | CHEMBL5083998 | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 43 | Q86U44_UYZ | UYZ | n/a | 156596354 | CHEMBL5084119 | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 44 | Q86U44_UZ2 | UZ2 | n/a | 156596355 | CHEMBL5081806 | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1-methyl-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 45 | Q86U44_UZ5 | UZ5 | n/a | 156587343 | CHEMBL5077332 | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-bis(fluoranyl)phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 46 | Q86U44_UZB | UZB | n/a | 156596356 | CHEMBL5076974 | 9-(2-chloranyl-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)-4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 47 | Q86U44_UZE | UZE | n/a | 156587344 | CHEMBL5092743 | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-fluoranyl-phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 48 | Q86U44_UZH | UZH | n/a | 156587345 | CHEMBL5078591 | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-3-fluoranyl-phenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one | n/a | |
| 49 | Q86U44_V0B | V0B | n/a | 155167543 | CHEMBL5423404 | N-[(6-methylimidazo[1,2-a]pyridin-2-yl)methyl]-4-oxidanylidene-pyrido[1,2-a]pyrimidine-2-carboxamide | n/a | |
| 50 | Q86U44_V22 | V22 | n/a | n/a | n/a | ~{N}-[[6-[(cyclohexylmethylamino)methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxidanylidene-1~{H}-pyrido[1,2-a]pyrimidine-2-carboxamide | n/a | |
| 51 | Q86U44_V9T | V9T | n/a | 156619956 | n/a | 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-N-[[(3R)-1-[6-(methylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-benzamide | n/a | |
| 52 | Q86U44_V9W | V9W | n/a | 156619955 | n/a | (3~{R})-3-[[5-[(4,4-dimethylpiperidin-1-yl)methyl]-1~{H}-benzimidazol-2-yl]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-ol | n/a | |
| 53 | Q86U44_VA8 | VA8 | n/a | 156619958 | n/a | ~{N}-[[(3~{R})-1-[6-(3~{H}-benzimidazol-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-4-[(4,4-dimethylpiperidin-1-yl)methyl]benzamide | n/a | |
| 54 | Q86U44_VAQ | VAQ | n/a | 156619957 | n/a | 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-2-oxidanyl-N-[[(3R)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide | n/a | |
| 55 | Q86U44_VAT | VAT | n/a | 156619952 | n/a | 4-(2-azaspiro[3.4]octan-2-ylmethyl)-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide | n/a | |
| 56 | Q86U44_VB2 | VB2 | n/a | 156619951 | n/a | 4-[(4,4-dimethylpiperidin-1-yl)methyl]-~{N}-[[(3~{S})-1-[6-(methylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-benzamide | n/a | |
| 57 | Q86U44_VB5 | VB5 | n/a | 156619950 | n/a | 4-[(4,4-dimethylpiperidin-1-yl)methyl]-~{N}-[[(3~{R})-1-[6-(methylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-benzamide | n/a | |
| 58 | Q86U44_VB8 | VB8 | n/a | 156619959 | n/a | 4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-methylsulfanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide | n/a | |
| 59 | Q86U44_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a |