Gene name: PIK3C3
Protein name: Phosphatidylinositol 3-kinase catalytic
List of molecules and drugs that interact with protein Q8NEB9
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q8NEB9_1TT | 1TT | n/a | 137347993 | n/a | (8S)-9-[(5-chloranylpyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3H-pyrimido[1,2-a]pyrimidin-4-one | n/a | |
| 2 | Q8NEB9_2UG | 2UG | n/a | 67983123 | CHEMBL3781415 | 4'-(cyclopropylmethyl)-N~2~-(pyridin-4-yl)-4,5'-bipyrimidine-2,2'-diamine | n/a | |
| 3 | Q8NEB9_5QS | 5QS | n/a | 67983918 | CHEMBL3781466 | 1-[[4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-yl]amino]-2-methyl-propan-2-ol | n/a | |
| 4 | Q8NEB9_7A5 | 7A5 | n/a | 72709284 | CHEMBL4586628 | (8S)-2-[(3R)-3-methylmorpholin-4-yl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one | n/a | |
| 5 | Q8NEB9_7IH | 7IH | n/a | 157049302 | CHEMBL5183804 | N-{4-[(7R,8R)-4-oxo-7-(propan-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl]pyridin-2-yl}cyclopropanecarboxamide | n/a | |
| 6 | Q8NEB9_7IK | 7IK | n/a | 157049303 | CHEMBL5193287 | (7R,8R)-2-[(3R)-3-methylmorpholin-4-yl]-7-(propan-2-yl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one | n/a | |
| 7 | Q8NEB9_7IQ | 7IQ | n/a | 157049304 | CHEMBL5207217 | (5aS,8aR,9S)-2-[(3R)-3-methylmorpholin-4-yl]-5,5a,6,7,8,8a-hexahydro-4H-cyclopenta[e]pyrazolo[1,5-a]pyrazin-4-one | n/a | |
| 8 | Q8NEB9_AJZ | AJZ | n/a | 9901372 | CHEMBL510164 | 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol | n/a | |
| 9 | Q8NEB9_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 10 | Q8NEB9_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 11 | Q8NEB9_EUT | EUT | n/a | 49854502 | CHEMBL4536855 | (8S)-9-[3,5-bis(fluoranyl)phenyl]-2-morpholin-4-yl-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one | n/a | |
| 12 | Q8NEB9_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 13 | Q8NEB9_H2E | H2E | n/a | 138753227 | CHEMBL4745255 | 2-morpholin-4-yl-6-[7-[(2~{R})-1-morpholin-4-ylpropan-2-yl]oxy-9~{H}-thioxanthen-4-yl]pyran-4-one | n/a | |
| 14 | Q8NEB9_JXM | JXM | n/a | 49853890 | CHEMBL4536755 | (8S)-9-[(2R)-2-hydroxy-2-phenylethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one | n/a | |
| 15 | Q8NEB9_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 16 | Q8NEB9_OZ8 | OZ8 | n/a | 155884468 | CHEMBL4873212 | 4-morpholin-4-yl-6-[(2~{R})-2-(phenylmethyl)pyrrolidin-1-yl]-1~{H}-pyridin-2-one | n/a | |
| 17 | Q8NEB9_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 18 | Q8NEB9_RBQ | RBQ | n/a | 57406937 | CHEMBL4470174 | (8S)-2-(morpholin-4-yl)-9-[2-(propan-2-yloxy)ethyl]-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one | n/a | |
| 19 | Q8NEB9_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 20 | Q8NEB9_UJB | UJB | n/a | 86278575 | n/a | (2S)-1-[(5-chloro-2-thienyl)methyl]-8-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one | n/a | |
| 21 | Q8NEB9_093 | 093 | DB06836 | 6852167 | CHEMBL1229535 | N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide | n/a | IC50(nM) = 307.0 |
| 22 | Q8NEB9_DB11962 | n/a | DB11962 | n/a | n/a | GSK-1059615 | inhibitor |