Gene name: DOT1L
Protein name: Histone-lysine N-methyltransferase, H3
List of molecules and drugs that interact with protein Q8TEK3
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q8TEK3_0QJ | 0QJ | n/a | 57384118 | CHEMBL3087500 | 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(methyl)amino]-5'-deoxyadenosine | n/a | |
| 2 | Q8TEK3_0QK | 0QK | n/a | 56962336 | CHEMBL2169919 | 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 3 | Q8TEK3_3US | 3US | n/a | 86280470 | n/a | N-[4-(acetylamino)butyl]-5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5'-deoxyadenosine | n/a | |
| 4 | Q8TEK3_5EG | 5EG | n/a | 121005803 | CHEMBL4589517 | 2-({5-[(2-chlorophenoxy)methyl]-1H-tetrazol-1-yl}acetyl)-N-(4-chlorophenyl)hydrazinecarboxamide | n/a | |
| 5 | Q8TEK3_5EK | 5EK | n/a | 121005804 | CHEMBL4586619 | N-[1-(2-chlorophenyl)-1H-indol-6-yl]-2-{[5-(2-chlorophenyl)-1H-tetrazol-1-yl]acetyl}hydrazinecarboxamide | n/a | |
| 6 | Q8TEK3_5EV | 5EV | n/a | 121005806 | CHEMBL4577516 | N~4~-methyl-N~2~-[2-methyl-1-(2-phenoxyphenyl)-1H-indol-6-yl]pyrimidine-2,4-diamine | n/a | |
| 7 | Q8TEK3_5EW | 5EW | n/a | 121005805 | CHEMBL4549878 | 6'-chloro-1,4-dimethyl-5'-(2-methyl-6-{[4-(methylamino)pyrimidin-2-yl]amino}-1H-indol-1-yl)-3,3'-bipyridin-2(1H)-one | n/a | |
| 8 | Q8TEK3_5F4 | 5F4 | n/a | 1478384 | CHEMBL1312860 | 4-(2,6-dichlorobenzoyl)-N-methyl-1H-pyrrole-2-carboxamide | n/a | |
| 9 | Q8TEK3_5F6 | 5F6 | n/a | 115790497 | CHEMBL4446675 | (2,6-dichlorophenyl)(quinolin-6-yl)methanone | n/a | |
| 10 | Q8TEK3_5F7 | 5F7 | n/a | 121005807 | CHEMBL4575148 | N-(2,6-dichlorophenyl)-4-methoxy-N-methylquinolin-6-amine | n/a | |
| 11 | Q8TEK3_5ID | 5ID | DB04604 | 97297 | CHEMBL99203 | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL | n/a | IC50(nM) = 7000.0 |
| 12 | Q8TEK3_5JJ | 5JJ | n/a | 124222435 | n/a | N~6~-(2,6-dichlorophenyl)-N~6~-(pent-2-yn-1-yl)quinoline-4,6-diamine | n/a | |
| 13 | Q8TEK3_5JT | 5JT | n/a | 67066693 | CHEMBL4074998 | (3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine | n/a | |
| 14 | Q8TEK3_5JU | 5JU | n/a | 137348361 | n/a | N~2~-{[2-chloro-3-(2-methylpyridin-3-yl)-1-benzothiophen-5-yl]carbamoyl}-N-(3-{methyl[(3R)-1-(5H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]amino}propyl)glycinamide | n/a | |
| 15 | Q8TEK3_6NR | 6NR | n/a | 121225442 | CHEMBL4588797 | (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid | n/a | |
| 16 | Q8TEK3_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 17 | Q8TEK3_ADN | ADN | DB00640 | 60961 | CHEMBL477 | ADENOSINE | n/a | IC50(nM) = 100000.0 |
| 18 | Q8TEK3_AW0 | AW0 | n/a | 56951878 | n/a | 5'-deoxy-5'-[(3-{[(4-methylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]adenosine | n/a | |
| 19 | Q8TEK3_AW1 | AW1 | n/a | 56951879 | CHEMBL2171169 | 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5'-deoxyadenosine | n/a | |
| 20 | Q8TEK3_AW2 | AW2 | n/a | 56962337 | CHEMBL3087498 | 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 21 | Q8TEK3_AW3 | AW3 | n/a | 56962338 | n/a | 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 22 | Q8TEK3_BR | BR | n/a | 259 | n/a | BROMIDE ION | n/a | |
| 23 | Q8TEK3_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 24 | Q8TEK3_EP4 | EP4 | n/a | 25231309 | CHEMBL472733 | 5'-deoxy-5'-(dimethylamino)adenosine | n/a | |
| 25 | Q8TEK3_EP6 | EP6 | DB12920 | n/a | CHEMBL3414626 | 5'-[{cis-3-[2-(5-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl}(propan-2-yl)amino]-5'-deoxyadenosine | modulator | |
| 26 | Q8TEK3_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 27 | Q8TEK3_IOD | IOD | n/a | 30165 | n/a | IODIDE ION | n/a | |
| 28 | Q8TEK3_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | |
| 29 | Q8TEK3_N4W | N4W | n/a | 145704694 | CHEMBL4531049 | ~{N}1-[(~{S})-(3-chlorophenyl)-pyridin-2-yl-methyl]-4-methylsulfonyl-~{N}2-pyrimidin-2-yl-benzene-1,2-diamine | n/a | |
| 30 | Q8TEK3_N4Z | N4Z | n/a | 145704695 | CHEMBL4446126 | ~{N}1-[(~{S})-[2,2-bis(fluoranyl)-1,3-benzodioxol-4-yl]-(3-chloranylpyridin-2-yl)methyl]-~{N}2-(4-methoxy-6-piperazin-1-yl-1,3,5-triazin-2-yl)-4-methylsulfonyl-benzene-1,2-diamine | n/a | |
| 31 | Q8TEK3_N5K | N5K | n/a | 145704696 | CHEMBL4435508 | 3-[(4-azanyl-6-methoxy-1,3,5-triazin-2-yl)amino]-4-[[(~{S})-[2,2-bis(fluoranyl)-1,3-benzodioxol-4-yl]-(3-chloranylpyridin-2-yl)methyl]amino]benzenesulfonamide | n/a | |
| 32 | Q8TEK3_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 33 | Q8TEK3_O4B | O4B | n/a | 28557 | CHEMBL155204 | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE | n/a | |
| 34 | Q8TEK3_SAH | SAH | DB01752 | 439155;25246222; | CHEMBL418052 | S-ADENOSYL-L-HOMOCYSTEINE | n/a | |
| 35 | Q8TEK3_SAM | SAM | DB00118 | n/a | CHEMBL1235831 | S-ADENOSYLMETHIONINE | n/a | |
| 36 | Q8TEK3_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 37 | Q8TEK3_TLA | TLA | DB09459 | 444305 | CHEMBL1236315 | L(+)-TARTARIC ACID | n/a | |
| 38 | Q8TEK3_TT8 | TT8 | n/a | 53377508;72200576; | CHEMBL2171174 | (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid | n/a | |
| 39 | Q8TEK3_UNX | UNX | n/a | |||||
| 40 | Q8TEK3_SX0 | SX0 | n/a | 53339032 | CHEMBL2349526 | (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid (non-preferred name) | n/a |