Gene name: ESR2
Protein name: Estrogen receptor beta
List of molecules and drugs that interact with protein Q92731
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q92731_041 | 041 | DB06832 | 656954 | CHEMBL450940 | 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL | agonist | IC50(nM) = 5.0 |
| 2 | Q92731_244 | 244 | DB06927 | 656953 | CHEMBL184151 | [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE | n/a | IC50(nM) = 14.0 |
| 3 | Q92731_272 | 272 | DB06937 | 5287464 | CHEMBL360410 | 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL | n/a | IC50(nM) = 3.5 |
| 4 | Q92731_338 | 338 | DB07009 | 4369550 | CHEMBL185918 | 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL | n/a | IC50(nM) = 5.0 |
| 5 | Q92731_397 | 397 | DB07032 | 656936 | CHEMBL367588 | 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL | inhibitor | IC50(nM) = 6.0 EC50(nM) = 5.7 |
| 6 | Q92731_3AS | 3AS | DB07036 | 16758226 | CHEMBL236720 | (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | n/a | Ki(nM) = 0.53 |
| 7 | Q92731_555 | 555 | DB07150 | 135440536 | CHEMBL395308 | 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME | inhibitor | |
| 8 | Q92731_697 | 697 | DB07198 | 656952 | CHEMBL363498 | 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE | n/a | IC50(nM) = 2.2 EC50(nM) = 1.9 |
| 9 | Q92731_789 | 789 | DB07230 | 10286462 | CHEMBL190467 | 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE | n/a | IC50(nM) = 20.0 |
| 10 | Q92731_797 | 797 | DB07236 | 5287551 | CHEMBL187105 | 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL | n/a | IC50(nM) = 1.0 |
| 11 | Q92731_DC8 | DC8 | DB07638 | 11197931 | CHEMBL236718 | (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL | n/a | Ki(nM) = 0.44 |
| 12 | Q92731_EST | EST | DB00783 | 5757 | CHEMBL135 | ESTRADIOL | agonist | Ki(nM) = 0.015 IC50(nM) = 0.046 Kd(nM) = 0.5 EC50(nM) = 0.01 |
| 13 | Q92731_ETC | ETC | n/a | 446849 | CHEMBL282489 | (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL | n/a | |
| 14 | Q92731_FBR | FBR | DB07757 | 11987846 | CHEMBL211614 | (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one | n/a | IC50(nM) = 1.5 |
| 15 | Q92731_GEN | GEN | DB01645 | 5280961 | CHEMBL44 | GENISTEIN | modulator | Ki(nM) = 24.0 IC50(nM) = 1.3 EC50(nM) = 2.4 |
| 16 | Q92731_I0G | I0G | DB07933 | 10286159 | CHEMBL278703 | (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL | agonist | Ki(nM) = 0.17 EC50(nM) = 0.66 |
| 17 | Q92731_I0K | I0K | n/a | 56945585 | CHEMBL1950809 | (2~{S})-2,3-bis(4-hydroxyphenyl)propanenitrile | n/a | |
| 18 | Q92731_I1D | I1D | n/a | 164513532 | n/a | (2~{R})-3-(2-chloranyl-4-oxidanyl-phenyl)-2-(4-hydroxyphenyl)propanenitrile | n/a | |
| 19 | Q92731_I1I | I1I | n/a | 164513533 | n/a | (2~{S})-3-(2-chloranyl-4-oxidanyl-phenyl)-2-(4-hydroxyphenyl)propanenitrile | n/a | |
| 20 | Q92731_I1M | I1M | n/a | 164513534 | n/a | (2~{R})-2-(2-chloranyl-4-oxidanyl-phenyl)-3-(4-hydroxyphenyl)propanenitrile | n/a | |
| 21 | Q92731_I2B | I2B | n/a | 164513535 | n/a | (2~{S})-2-(2-chloranyl-4-oxidanyl-phenyl)-3-(4-hydroxyphenyl)propanenitrile | n/a | |
| 22 | Q92731_JJ3 | JJ3 | DB08020 | 9927355 | CHEMBL236086 | (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL | n/a | Ki(nM) = 0.28 |
| 23 | Q92731_KB0 | KB0 | n/a | 58027337 | n/a | 2-(4-hydroxyphenyl)-7-methyl-3-phenyl-1H-inden-5-ol | n/a | |
| 24 | Q92731_MON | MON | DB04020 | 9957008 | CHEMBL346455 | 4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL | n/a | Ki(nM) = 15.0 IC50(nM) = 6.0 |
| 25 | Q92731_OHT | OHT | DB04468 | 449459 | CHEMBL489 | 4-HYDROXYTAMOXIFEN | n/a | |
| 26 | Q92731_W14 | W14 | n/a | 50919273 | CHEMBL1615275 | 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-7-ol | n/a | |
| 27 | Q92731_W23 | W23 | n/a | 50919274 | CHEMBL1615276 | 2-[(trifluoromethyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-6-ol | n/a | |
| 28 | Q92731_WV7 | WV7 | n/a | 18695694 | CHEMBL1213617 | 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-6-ol | n/a | |
| 29 | Q92731_YJD | YJD | n/a | 53301834 | n/a | 4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL | n/a | |
| 30 | Q92731_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 31 | Q92731_SU4 | SU4 | n/a | 53483961 | CHEMBL1836907 | N-cyclopropyl-4-oxidanyl-N-[(2R)-2-oxidanyl-2-phenyl-propyl]benzenesulfonamide | n/a | |
| 32 | Q92731_DES | DES | DB00255 | 448537 | CHEMBL411 | Diethylstilbestrol | agonist | |
| 33 | Q92731_STR | STR | DB00396 | 5994 | CHEMBL103 | Progesterone | agonist | |
| 34 | Q92731_RAL | RAL | DB00481 | 5035 | CHEMBL81 | Raloxifene | agonist | Ki(nM) = 2.74 IC50(nM) = 1.6 EC50(nM) = 4.32 |
| 35 | Q92731_J3Z | J3Z | DB00655 | 5870 | CHEMBL1405 | Estrone | n/a | IC50(nM) = 31.0 EC50(nM) = 0.5 |
| 36 | Q92731_CTX | CTX | DB00675 | 2733526 | CHEMBL83 | Tamoxifen | antagonist | Ki(nM) = 0.51 IC50(nM) = 5.0 EC50(nM) = 1000.0 |
| 37 | Q92731_DB01108 | n/a | DB01108 | n/a | n/a | Trilostane | allosteric modulator | |
| 38 | Q92731_DB01196 | n/a | DB01196 | n/a | n/a | Estramustine | other/unknown | |
| 39 | Q92731_DB01428 | n/a | DB01428 | n/a | n/a | Oxybenzone | n/a | |
| 40 | Q92731_AND | AND | DB01708 | 5881 | CHEMBL90593 | Prasterone | activator | |
| 41 | Q92731_BZQ | BZQ | DB01878 | 3102 | CHEMBL90039 | Benzophenone | n/a | |
| 42 | Q92731_PHT | PHT | DB02746 | 1017;18183610; | CHEMBL1045 | Phthalic Acid | n/a | |
| 43 | Q92731_PZO | PZO | DB02757 | 1048 | CHEMBL15967 | Pyrazole | n/a | |
| 44 | Q92731_PMB | PMB | DB02983 | 65258 | n/a | Para-Mercury-Benzenesulfonic Acid | inhibitor | |
| 45 | Q92731_NAR | NAR | DB03467 | 439246 | CHEMBL9352 | Naringenin | partial agonist | |
| 46 | Q92731_AOE | AOE | DB03860 | 104772 | CHEMBL1222035 | ICI-164384 | inhibitor | |
| 47 | Q92731_AOM | AOM | DB03882 | 242332 | CHEMBL316048 | 5-Alpha-Androstane-3-Beta,17beta-Diol | agonist | |
| 48 | Q92731_QUE | QUE | DB04216 | 5280343 | CHEMBL50 | Quercetin | n/a | |
| 49 | Q92731_ESL | ESL | DB04573 | 5756 | CHEMBL193482 | Estriol | agonist | |
| 50 | Q92731_DB04574 | n/a | DB04574 | n/a | n/a | Estrone sulfate | agonist | |
| 51 | Q92731_DB05966 | n/a | DB05966 | n/a | n/a | TAS-108 | n/a | |
| 52 | Q92731_C3D | C3D | DB06202 | 216416 | CHEMBL328190 | Lasofoxifene | agonist | |
| 53 | Q92731_DB06249 | n/a | DB06249 | n/a | n/a | Arzoxifene | inhibitor | |
| 54 | Q92731_29S | 29S | DB06401 | 154257 | CHEMBL46740 | Bazedoxifene | n/a | IC50(nM) = 3.8 |
| 55 | Q92731_196 | 196 | DB06875 | 6102691 | CHEMBL192154 | ERB-196 | agonist | IC50(nM) = 2.7 |
| 56 | Q92731_4NA | 4NA | DB07119 | 6102690 | CHEMBL364092 | 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL | inhibitor | IC50(nM) = 2.52 |
| 57 | Q92731_E3O | E3O | DB07702 | 256737 | CHEMBL1232445 | 17alpha-Estriol | n/a | |
| 58 | Q92731_EOL | EOL | DB09086 | 3314 | CHEMBL42710 | Eugenol | n/a | |
| 59 | Q92731_DB09535 | n/a | DB09535 | n/a | n/a | Octocrylene | n/a | |
| 60 | Q92731_DB11219 | n/a | DB11219 | n/a | n/a | Enzacamene | n/a | |
| 61 | Q92731_DB11674 | n/a | DB11674 | n/a | n/a | Equol | agonist | |
| 62 | Q92731_4OH | 4OH | DB12235 | 27125 | CHEMBL1230314 | Estetrol | agonist | |
| 63 | Q92731_DB13310 | n/a | DB13310 | n/a | n/a | Ormeloxifene | modulator | |
| 64 | Q92731_DB13869 | n/a | DB13869 | n/a | n/a | 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol | n/a | |
| 65 | Q92731_DB13952 | n/a | DB13952 | n/a | n/a | Estradiol acetate | agonist | |
| 66 | Q92731_DB13953 | n/a | DB13953 | n/a | n/a | Estradiol benzoate | agonist | |
| 67 | Q92731_DB13954 | n/a | DB13954 | n/a | n/a | Estradiol cypionate | agonist | |
| 68 | Q92731_DB13955 | n/a | DB13955 | n/a | n/a | Estradiol dienanthate | agonist | |
| 69 | Q92731_DB13956 | n/a | DB13956 | n/a | n/a | Estradiol valerate | agonist | |
| 70 | Q92731_DB14641 | n/a | DB14641 | n/a | n/a | Estriol tripropionate | n/a | |
| 71 | Q92731_DB15690 | n/a | DB15690 | n/a | n/a | Fluoroestradiol F-18 | binder |