Gene name: HDAC2
Protein name: Histone deacetylase 2
List of molecules and drugs that interact with protein Q92769
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q92769_1PE | 1PE | n/a | 62551 | CHEMBL1229766 | PENTAETHYLENE GLYCOL | n/a | |
| 2 | Q92769_20Y | 20Y | n/a | 6918878 | CHEMBL235842 | 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide | n/a | |
| 3 | Q92769_2OP | 2OP | DB14475 | 107689 | CHEMBL330546 | (2S)-2-HYDROXYPROPANOIC ACID | n/a | |
| 4 | Q92769_6EZ | 6EZ | n/a | n/a | CHEMBL3827611 | (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide | n/a | |
| 5 | Q92769_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 6 | Q92769_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 7 | Q92769_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 8 | Q92769_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 9 | Q92769_EL8 | EL8 | n/a | 134611723 | CHEMBL4242292 | (6~{R})-6-[[3,4-bis(oxidanylidene)-2-[[4-(trifluoromethyloxy)phenyl]amino]cyclobuten-1-yl]amino]-~{N}-oxidanyl-heptanamide | n/a | |
| 10 | Q92769_IWX | IWX | n/a | 71465631 | CHEMBL3828396 | N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide | n/a | |
| 11 | Q92769_KIZ | KIZ | n/a | 164890220 | n/a | [(2~{R})-1-(dimethylamino)-3-(4-fluorophenyl)-1-oxidanylidene-propan-2-yl]azanium | n/a | |
| 12 | Q92769_KJ6 | KJ6 | n/a | 54675757 | CHEMBL54907 | 6-methyl-4-oxidanyl-pyran-2-one | n/a | |
| 13 | Q92769_KJF | KJF | n/a | 164890223 | n/a | [(2~{R})-1-oxidanylidene-4-phenyl-1-pyrrolidin-1-yl-butan-2-yl]azanium | n/a | |
| 14 | Q92769_KJN | KJN | n/a | 164890222 | n/a | [(2~{R})-1-(dimethylamino)-1-oxidanylidene-4-phenyl-butan-2-yl]azanium | n/a | |
| 15 | Q92769_KK0 | KK0 | n/a | 71662117 | n/a | (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one | n/a | |
| 16 | Q92769_KKI | KKI | n/a | 164890224 | CHEMBL5208116 | 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile | n/a | |
| 17 | Q92769_KKW | KKW | n/a | 164890225 | CHEMBL5199411 | [(2~{R},4~{S})-4-(3-chlorophenyl)pyrrolidin-2-yl]-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)methanone | n/a | |
| 18 | Q92769_KRU | KRU | n/a | 164890226 | n/a | 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone | n/a | |
| 19 | Q92769_KZF | KZF | DB03309 | 66898;3852474; | n/a | 2-(cyclohexylazaniumyl)ethanesulfonate | n/a | |
| 20 | Q92769_LLX | LLX | n/a | 44454143 | CHEMBL271741 | N-(4-aminobiphenyl-3-yl)benzamide | n/a | |
| 21 | Q92769_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 22 | Q92769_NHE | NHE | DB03309 | 66898;3852474; | n/a | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | n/a | |
| 23 | Q92769_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 24 | Q92769_PG4 | PG4 | n/a | 8200 | CHEMBL1235254 | TETRAETHYLENE GLYCOL | n/a | |
| 25 | Q92769_PG5 | PG5 | DB02078 | 8189 | CHEMBL1235255 | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE | n/a | |
| 26 | Q92769_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 27 | Q92769_SHH | SHH | DB02546 | 5311 | CHEMBL98 | OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE | inhibitor | Ki(nM) = 7.0 IC50(nM) = 1.7 Kd(nM) = 163.0 |
| 28 | Q92769_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 29 | Q92769_TV1 | TV1 | n/a | 146027050 | n/a | N-{(1S)-7,7-dihydroxy-1-[5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl]nonyl}-1-methylazetidine-3-carboxamide | n/a | |
| 30 | Q92769_TV7 | TV7 | n/a | 146027051 | n/a | (1S)-N-{(1S)-7,7-dihydroxy-1-[5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl]nonyl}-6-ethyl-6-azaspiro[2.5]octane-1-carboxamide | n/a | |
| 31 | Q92769_V1D | V1D | n/a | 146680858 | n/a | N-[(1S)-1-[4-(2-fluorophenyl)-1H-imidazol-2-yl]-7,7-dihydroxy-7-(1,2-oxazol-3-yl)heptyl]-1-methylazetidine-3-carboxamide | n/a | |
| 32 | Q92769_V1P | V1P | n/a | 153835402 | n/a | 5-{(1S)-7,7-dihydroxy-1-[(1-methylazetidine-3-carbonyl)amino]nonyl}-2-phenyl-1H-imidazole-4-carboxamide | n/a | |
| 33 | Q92769_V1S | V1S | n/a | 153835403 | n/a | (1S)-N-{(1S)-1-[5-cyano-2-(4-fluorophenyl)-1H-imidazol-4-yl]-7,7-dihydroxynonyl}-6-methyl-6-azaspiro[2.5]octane-1-carboxamide | n/a | |
| 34 | Q92769_VJV | VJV | n/a | 156026017 | n/a | (1S)-N-{(1S)-7,7-dihydroxy-1-[4-(2-methylquinolin-6-yl)-1H-imidazol-2-yl]nonyl}-6-methyl-6-azaspiro[2.5]octane-1-carboxamide | n/a | |
| 35 | Q92769_WB4 | WB4 | n/a | 155289405 | CHEMBL4763995 | N-{(1S)-5-{[2-(methylsulfanyl)benzene-1-carbonyl]amino}-1-[5-(naphthalen-2-yl)-1H-imidazol-2-yl]pentyl}-1,3-thiazole-5-carboxamide | n/a | |
| 36 | Q92769_WBA | WBA | n/a | 155289404 | CHEMBL4753111 | N-{(1S)-5-[(2-fluoro-6-hydroxybenzene-1-carbonyl)amino]-1-[5-(naphthalen-2-yl)-1H-imidazol-2-yl]pentyl}-1,3-thiazole-5-carboxamide | n/a | |
| 37 | Q92769_WBD | WBD | n/a | 335473 | n/a | 2,5-dichloro-1H-benzimidazole | n/a | |
| 38 | Q92769_YED | YED | n/a | 155907154 | n/a | (3S,6S,9S,15aR)-9-[(2S)-butan-2-yl]-3-(6,6-dihydroxyoctyl)-6-[(1-methoxy-1H-indol-3-yl)methyl]octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone | n/a | |
| 39 | Q92769_YEM | YEM | n/a | 155907155 | CHEMBL4851511 | N-{(1S)-1-[5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl]pentyl}-1-methylazetidine-3-carboxamide | n/a | |
| 40 | Q92769_YEV | YEV | n/a | 155907156 | CHEMBL4861270 | (2R)-2-(5-hydroxy-2-methyl-1H-indol-3-yl)-N-{(1S)-1-[5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl]pentyl}propanamide | n/a | |
| 41 | Q92769_ZL4 | ZL4 | n/a | n/a | n/a | (1R,3S,6S,18R,27R)-6-(6,6-dihydroxyoctyl)-5,8,18,27,34-pentaazahexacyclo[25.2.2.1~7,10~.1~11,15~.1~14,18~.0~1,3~]tetratriaconta-7,9,11(33),12,14,16-hexaene-4,32-dione (non-preferred name) | n/a | |
| 42 | Q92769_ZLM | ZLM | n/a | 155937506 | n/a | (1S)-6-ethyl-N-{(1S)-1-[5-(2-ethyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-1H-imidazol-2-yl]-7,7-dihydroxynonyl}-6-azaspiro[2.5]octane-1-carboxamide | n/a | |
| 43 | Q92769_ZLS | ZLS | n/a | 155937505 | n/a | (1S)-N-[(1S)-7,7-dihydroxy-1-{4-[(1R,4S)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl]-1H-imidazol-2-yl}nonyl]-6-methyl-6-azaspiro[2.5]octane-1-carboxamide | n/a | |
| 44 | Q92769_ZLV | ZLV | n/a | 155937504 | n/a | (3S,18S,20aR)-18-(6,6-dihydroxyoctyl)-1,5,6,7,8,18,19,20a-octahydro-4H-14,17-epiminoazeto[1,2-g][1,7,10,13]benzoxatriazacycloheptadecin-20(2H)-one | n/a | |
| 45 | Q92769_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 46 | Q92769_DB00175 | n/a | DB00175 | n/a | n/a | Pravastatin | inhibitor | |
| 47 | Q92769_803 | 803 | DB00227 | 53232 | CHEMBL503 | Lovastatin | inhibitor | IC50(nM) = 25933.0 |
| 48 | Q92769_TEP | TEP | DB00277 | 2153 | CHEMBL190 | Theophylline | activator | |
| 49 | Q92769_2PP | 2PP | DB00313 | n/a | n/a | Valproic acid | inhibitor | IC50(nM) = 62000.0 |
| 50 | Q92769_DB00641 | n/a | DB00641 | n/a | n/a | Simvastatin | inhibitor | |
| 51 | Q92769_117 | 117 | DB01076 | 60823 | CHEMBL1487 | Atorvastatin | inhibitor | |
| 52 | Q92769_DB01095 | n/a | DB01095 | n/a | n/a | Fluvastatin | inhibitor | |
| 53 | Q92769_DB01223 | n/a | DB01223 | n/a | n/a | Aminophylline | activator | |
| 54 | Q92769_DB01303 | n/a | DB01303 | n/a | n/a | Oxtriphylline | activator | |
| 55 | Q92769_DB05223 | n/a | DB05223 | n/a | n/a | Pracinostat | n/a | |
| 56 | Q92769_DB06176 | n/a | DB06176 | n/a | n/a | Romidepsin | antagonist | |
| 57 | Q92769_DB09091 | n/a | DB09091 | n/a | n/a | Tixocortol | stimulator | |
| 58 | Q92769_DB11830 | n/a | DB11830 | n/a | n/a | Mocetinostat | n/a |