Gene name: MAP4K1
Protein name: Mitogen-activated protein kinase
List of molecules and drugs that interact with protein Q92918
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q92918_2TR | 2TR | n/a | 146536730 | n/a | 6-amino-3-[(1S,3R)-4'-chloro-3-hydroxy-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl]-2-fluoro-N,N-dimethylbenzamide | n/a | |
| 2 | Q92918_2WI | 2WI | n/a | 162394528 | n/a | 6-amino-2-fluoro-N,N-dimethyl-3-(4'-methylspiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl)benzamide | n/a | |
| 3 | Q92918_2YE | 2YE | n/a | 162393548 | CHEMBL5093381 | 2-amino-N,N-dimethyl-5-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide | n/a | |
| 4 | Q92918_9ID | 9ID | n/a | 162639718 | CHEMBL5206785 | 6-[(5R)-5-benzamidocyclohex-1-en-1-yl]-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide | n/a | |
| 5 | Q92918_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 6 | Q92918_B49 | B49 | DB01268 | 5329102 | CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide | n/a | Kd(nM) = 16.0 |
| 7 | Q92918_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 8 | Q92918_F97 | F97 | n/a | 135393494 | n/a | N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3R)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-amine | n/a | |
| 9 | Q92918_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 10 | Q92918_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 11 | Q92918_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 12 | Q92918_UES | UES | n/a | 168451697 | CHEMBL5396693 | ~{N}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine | n/a | |
| 13 | Q92918_USF | USF | n/a | 135342806 | CHEMBL5439907 | 2-[[8-azanyl-7-fluoranyl-6-(8-methyl-2,3-dihydro-1~{H}-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl]amino]-6-propan-2-yl-5,8-dihydro-4~{H}-pyrazolo[1,5-d][1,4]diazepin-7-one | n/a | |
| 14 | Q92918_W9D | W9D | n/a | 142587219 | CHEMBL4748154 | 5-{[4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino}-3,3-dimethyl-2-benzofuran-1(3H)-one | n/a | |
| 15 | Q92918_XHM | XHM | n/a | 155817684 | CHEMBL4754671 | 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1H-indazole-5-carbonitrile | n/a | |
| 16 | Q92918_XHS | XHS | n/a | 155817683 | CHEMBL4760447 | 6-(2-fluoro-6-methoxyphenyl)-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-1H-pyrazolo[4,3-c]pyridine | n/a | |
| 17 | Q92918_XHV | XHV | n/a | 155817682 | CHEMBL4779011 | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazolo[4,3-c]pyridine | n/a | |
| 18 | Q92918_XXF | XXF | n/a | 167530913 | CHEMBL5415748 | (3P)-3-[6-chloro-4-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | n/a | |
| 19 | Q92918_Y3I | Y3I | n/a | 167530914 | CHEMBL5423993 | (3P)-3-{4-[(3R,5S)-3-amino-5-methylpiperidin-1-yl]-6-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile | n/a | |
| 20 | Q92918_Y3O | Y3O | n/a | 167530915 | CHEMBL5424617 | (3P)-3-{4-[(2S,5R)-5-amino-2-methylpiperidin-1-yl]-6-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl}benzonitrile | n/a | |
| 21 | Q92918_YK1 | YK1 | n/a | 155883041 | CHEMBL4878586 | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | n/a | |
| 22 | Q92918_YK4 | YK4 | n/a | 155883040 | CHEMBL4863492 | 4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | n/a | |
| 23 | Q92918_YK7 | YK7 | n/a | 155883039 | CHEMBL4868487 | 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | n/a | |
| 24 | Q92918_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |