Gene name: NR1H4
Protein name: Bile acid receptor
List of molecules and drugs that interact with protein Q96RI1
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q96RI1_034 | 034 | n/a | 25131364 | CHEMBL1835049 | 5-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1H-indole-2-carboxylic acid | n/a | |
| 2 | Q96RI1_064 | 064 | n/a | 9893571 | CHEMBL318457 | 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid | n/a | |
| 3 | Q96RI1_088 | 088 | n/a | 25167372 | CHEMBL562086 | 3-[(5-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1H-indol-1-yl)methyl]benzoic acid | n/a | |
| 4 | Q96RI1_0X0 | 0X0 | n/a | 1809152 | n/a | 2-[(3,4-dimethoxyphenyl)-(4-methylphenyl)sulfonyl-amino]-N-(2,4-dimethylpentan-3-yl)ethanamide | n/a | |
| 5 | Q96RI1_31D | 31D | n/a | 1255603 | CHEMBL4854082 | 4-({2-[(4-tert-butylbenzoyl)amino]benzoyl}amino)benzoic acid | n/a | |
| 6 | Q96RI1_33Y | 33Y | DB12719 | 10026128 | CHEMBL454138 | 1-methylethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate | modulator | |
| 7 | Q96RI1_37G | 37G | n/a | 25108827 | CHEMBL1835044 | 6-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1H-indole-3-carboxylic acid | n/a | |
| 8 | Q96RI1_59G | 59G | n/a | 25132043 | CHEMBL1834968 | 6-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1-benzothiophene-3-carboxylic acid | n/a | |
| 9 | Q96RI1_643 | 643 | n/a | 25220917 | CHEMBL466323 | 6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid | n/a | |
| 10 | Q96RI1_708 | 708 | n/a | n/a | n/a | 3-[(E)-2-(2-chloro-4-{[3-{[(R)-(2,6-dichlorophenyl)(hydroxy)-lambda~4~-sulfanyl]methyl}-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid | n/a | |
| 11 | Q96RI1_7VX | 7VX | n/a | 137348668 | n/a | (4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | n/a | |
| 12 | Q96RI1_811 | 811 | DB15168 | 71228883 | CHEMBL4297613 | 2-[3-[4-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-2-chloranyl-phenyl]-3-oxidanyl-azetidin-1-yl]pyridine-4-carboxylic acid | agonist | |
| 13 | Q96RI1_82X | 82X | n/a | 25166350 | CHEMBL558143 | 3-(6-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1-benzothiophen-2-yl)benzoic acid | n/a | |
| 14 | Q96RI1_93O | 93O | n/a | 15686619 | n/a | 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate | n/a | |
| 15 | Q96RI1_93R | 93R | n/a | 62970 | n/a | ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate | n/a | |
| 16 | Q96RI1_93U | 93U | n/a | 3017161 | n/a | 2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate | n/a | |
| 17 | Q96RI1_9KV | 9KV | n/a | 126962399 | n/a | (2S)-N,2-dicyclohexyl-2-[2-(5-phenylthiophen-2-yl)-1H-benzimidazol-1-yl]acetamide | n/a | |
| 18 | Q96RI1_9KY | 9KY | n/a | 25133131 | n/a | (2S)-N,2-dicyclohexyl-2-{2-[4-(hydroxymethyl)phenyl]-1H-benzimidazol-1-yl}acetamide | n/a | |
| 19 | Q96RI1_9L1 | 9L1 | n/a | 126962420 | n/a | 5-{[(3beta,5beta,14beta,17alpha)-3-hydroxy-24-oxocholan-24-yl]amino}benzene-1,3-dicarboxylic acid | n/a | |
| 20 | Q96RI1_9L4 | 9L4 | n/a | 53319654 | CHEMBL1668243 | 3-chloro-4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)benzoic acid | n/a | |
| 21 | Q96RI1_9L7 | 9L7 | n/a | 126962403 | n/a | (2S)-2-{2-[4-(benzenecarbonyl)phenyl]-1H-benzimidazol-1-yl}-N,2-dicyclohexylacetamide | n/a | |
| 22 | Q96RI1_9LA | 9LA | n/a | 126962416 | n/a | 4-{(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylethoxy}benzoic acid | n/a | |
| 23 | Q96RI1_9LD | 9LD | n/a | 126962406 | n/a | ethyl 4-({2-phenyl-5-[(thiophen-2-yl)sulfonyl]-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carbonyl}amino)benzoate | n/a | |
| 24 | Q96RI1_9LG | 9LG | n/a | 126962404 | n/a | N,1-dibenzyl-6-[(2-fluorophenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide | n/a | |
| 25 | Q96RI1_9LJ | 9LJ | n/a | 126962413 | n/a | (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-N-(2-cyanophenyl)-2-cyclohexylacetamide | n/a | |
| 26 | Q96RI1_9LM | 9LM | n/a | 126962405 | n/a | 2-phenyl-N-(propan-2-yl)-6-[(thiophen-2-yl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxamide | n/a | |
| 27 | Q96RI1_9LP | 9LP | n/a | n/a | n/a | trans-4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)cyclohexyl hydrogen sulfate | n/a | |
| 28 | Q96RI1_9LS | 9LS | n/a | 126962412 | n/a | (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-fluorophenyl)acetamide | n/a | |
| 29 | Q96RI1_9LV | 9LV | n/a | 126962402 | n/a | 4-({5-bromo-1'-[(2-chlorophenyl)sulfonyl]-2-oxospiro[indole-3,4'-piperidin]-1(2H)-yl}methyl)benzoic acid | n/a | |
| 30 | Q96RI1_9LY | 9LY | n/a | 126962414 | n/a | (2S)-N,2-dicyclohexyl-2-{5,6-difluoro-2-[6-(1H-pyrazol-1-yl)pyridin-3-yl]-1H-benzimidazol-1-yl}acetamide | n/a | |
| 31 | Q96RI1_9M1 | 9M1 | n/a | 137348838 | n/a | ethyl (5S)-3-(3,4-difluorobenzene-1-carbonyl)-1,1-dimethyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate | n/a | |
| 32 | Q96RI1_9M4 | 9M4 | n/a | 126962407 | n/a | N-[3-(acetylamino)phenyl]-4-chloro-N-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]benzamide | n/a | |
| 33 | Q96RI1_9M7 | 9M7 | n/a | 126962398 | n/a | N,N-dicyclohexyl-3-(2,4-dichlorophenyl)-5-methyl-1,2-oxazole-4-carboxamide | n/a | |
| 34 | Q96RI1_9MA | 9MA | n/a | 59579045 | n/a | 2-(2,6-difluorophenyl)-N-(2,6-dimethylphenyl)-5-methylimidazo[1,2-a]pyridin-3-amine | n/a | |
| 35 | Q96RI1_9MD | 9MD | n/a | 126962408 | n/a | (2S)-2-[6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-benzimidazol-1-yl]-N-cyclohexyl-2-[(2S)-oxan-2-yl]acetamide | n/a | |
| 36 | Q96RI1_9MM | 9MM | n/a | 126962415 | n/a | 4-{(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylethoxy}-3-fluorobenzoic acid | n/a | |
| 37 | Q96RI1_9MP | 9MP | n/a | 126962410 | n/a | (2S)-N,2-dicyclohexyl-2-{5,6-difluoro-2-[(R)-methoxy(phenyl)methyl]-1H-benzimidazol-1-yl}acetamide | n/a | |
| 38 | Q96RI1_9MS | 9MS | n/a | 42605698 | n/a | (2S)-2-{2-[(4-chloro-2-methylphenoxy)methyl]-6-fluoro-1H-benzimidazol-1-yl}-N,2-dicyclohexylacetamide | n/a | |
| 39 | Q96RI1_9MV | 9MV | n/a | 126962400 | n/a | 4-({5-bromo-2-oxo-1'-[(thiophen-2-yl)sulfonyl]spiro[indole-3,4'-piperidin]-1(2H)-yl}methyl)benzoic acid | n/a | |
| 40 | Q96RI1_9MY | 9MY | n/a | n/a | n/a | (2S)-2-cyclohexyl-2-{5,6-difluoro-2-[(R)-methoxy(phenyl)methyl]-1H-benzimidazol-1-yl}-N-(trans-4-hydroxycyclohexyl)acetamide | n/a | |
| 41 | Q96RI1_9N1 | 9N1 | n/a | 68690413 | n/a | (2S)-N,2-dicyclohexyl-2-[2-(2,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]acetamide | n/a | |
| 42 | Q96RI1_9N4 | 9N4 | n/a | 68697118 | n/a | (2S)-2-cyclohexyl-2-[2-(2,4-dimethoxyphenyl)-1H-benzimidazol-1-yl]-N-(2,6-dimethylphenyl)acetamide | n/a | |
| 43 | Q96RI1_9N7 | 9N7 | n/a | 126962422 | n/a | 4-{[(2S)-2-cyclohexyl-2-{5,6-difluoro-2-[4-(1,3-thiazol-2-yl)phenyl]-1H-benzimidazol-1-yl}acetyl]amino}benzoic acid | n/a | |
| 44 | Q96RI1_9NA | 9NA | n/a | n/a | n/a | (2S)-2-cyclohexyl-2-[2-(2,6-dimethoxypyridin-3-yl)-5,6-difluoro-1H-benzimidazol-1-yl]-N-(trans-4-hydroxycyclohexyl)acetamide | n/a | |
| 45 | Q96RI1_9ND | 9ND | n/a | 126962409 | n/a | (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-phenylacetamide | n/a | |
| 46 | Q96RI1_9NG | 9NG | n/a | 126962401 | n/a | 5-bromo-1-{[4-(1H-tetrazol-5-yl)phenyl]methyl}-1'-(thiophene-2-sulfonyl)spiro[indole-3,4'-piperidin]-2(1H)-one | n/a | |
| 47 | Q96RI1_9NJ | 9NJ | n/a | n/a | n/a | trans-4-({(2S)-2-cyclohexyl-2-[2-(2,6-dimethoxypyridin-3-yl)-5-fluoro-1H-benzimidazol-1-yl]acetyl}amino)cyclohexane-1-carboxylic acid | n/a | |
| 48 | Q96RI1_9NM | 9NM | n/a | 126962397 | n/a | (2E)-N-cyclohexyl-N-(cyclohexylcarbamoyl)-3-(4-fluorophenyl)prop-2-enamide | n/a | |
| 49 | Q96RI1_9NP | 9NP | n/a | 25133089 | n/a | (2S)-N,2-dicyclohexyl-2-{2-[4-(1H-tetrazol-5-yl)phenyl]-1H-benzimidazol-1-yl}acetamide | n/a | |
| 50 | Q96RI1_9O1 | 9O1 | n/a | 126962411 | n/a | 3-(2-chlorophenyl)-N-[(1R)-1-(naphthalen-2-yl)ethyl]-5-(propan-2-yl)-1,2-oxazole-4-carboxamide | n/a | |
| 51 | Q96RI1_9R0 | 9R0 | n/a | n/a | n/a | 2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic acid | n/a | |
| 52 | Q96RI1_9R3 | 9R3 | n/a | n/a | n/a | 2-[(1R,5S)-9-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-3-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzothiazole-6-carboxylic acid | n/a | |
| 53 | Q96RI1_AWL | AWL | n/a | n/a | n/a | 1-adamantyl-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]methanone | n/a | |
| 54 | Q96RI1_BU3 | BU3 | n/a | 225936 | n/a | (R,R)-2,3-BUTANEDIOL | n/a | |
| 55 | Q96RI1_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 56 | Q96RI1_D5H | D5H | DB15446 | 9820008 | CHEMBL197194 | 2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid | n/a | |
| 57 | Q96RI1_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 58 | Q96RI1_FEX | FEX | DB02545 | 49866978 | n/a | METHYL 3-{3-[(CYCLOHEXYLCARBONYL){[4'-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE | inhibitor | Kd(nM) = 1220000.0 EC50(nM) = 25.0 |
| 59 | Q96RI1_FEZ | FEZ | n/a | 125180112 | n/a | (1S,2S,3Z,5S,8Z)-5-hydroxy-5,9-dimethyl-2-(propan-2-yl)cyclodeca-3,8-dien-1-yl 4-hydroxybenzoate | n/a | |
| 60 | Q96RI1_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 61 | Q96RI1_GWF | GWF | DB16343 | n/a | CHEMBL4298169 | Tropifexor | agonist | |
| 62 | Q96RI1_IUS | IUS | n/a | n/a | n/a | (1s,3s)-N-({4-[5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl]bicyclo[2.2.2]octan-1-yl}methyl)-3-hydroxy-N-[4'-(2-hydroxypropan-2-yl)[1,1'-biphenyl]-3-yl]-3-(trifluoromethyl)cyclobutane-1-carboxamide | n/a | |
| 63 | Q96RI1_IVM | IVM | n/a | 6321424 | CHEMBL263291 | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside | n/a | |
| 64 | Q96RI1_JN3 | JN3 | DB06777 | 10133 | CHEMBL240597 | CHENODEOXYCHOLIC ACID | agonist | EC50(nM) = 1000.0 |
| 65 | Q96RI1_MRD | MRD | n/a | 5288845 | n/a | (4R)-2-METHYLPENTANE-2,4-DIOL | n/a | |
| 66 | Q96RI1_MUF | MUF | DB08220 | 9845059 | n/a | (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid | n/a | |
| 67 | Q96RI1_NIW | NIW | n/a | 529928 | n/a | 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate | n/a | |
| 68 | Q96RI1_O62 | O62 | n/a | 16214849 | CHEMBL476302 | 6-(4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)naphthalene-1-carboxylic acid | n/a | |
| 69 | Q96RI1_OKH | OKH | n/a | 49817356 | n/a | 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid | n/a | |
| 70 | Q96RI1_OKI | OKI | n/a | 49817357 | n/a | (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide | n/a | |
| 71 | Q96RI1_OLF | OLF | n/a | 49837867 | CHEMBL1615150 | 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid | n/a | |
| 72 | Q96RI1_OMK | OMK | n/a | 49837868 | n/a | (2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexyl-N-(2-methylphenyl)ethanamide | n/a | |
| 73 | Q96RI1_OMM | OMM | n/a | 49837869 | CHEMBL1615152 | 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-fluorobenzoic acid | n/a | |
| 74 | Q96RI1_OOF | OOF | n/a | 49837870 | CHEMBL1615153 | 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)benzoic acid | n/a | |
| 75 | Q96RI1_OOK | OOK | n/a | 49837871 | CHEMBL1615154 | 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3,5-difluorobenzoic acid | n/a | |
| 76 | Q96RI1_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 77 | Q96RI1_XAW | XAW | n/a | n/a | n/a | [(3s,5s,7s)-adamantan-1-yl][4-(2-amino-5-chlorophenyl)piperazin-1-yl]methanone | n/a | |
| 78 | Q96RI1_XD4 | XD4 | n/a | 137332063 | n/a | [(1R,2R,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl] 4-azanyl-3-methyl-benzoate | n/a | |
| 79 | Q96RI1_XD5 | XD5 | n/a | 137332064 | n/a | [(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl] 4-azanylbenzoate | n/a | |
| 80 | Q96RI1_XX9 | XX9 | n/a | 91664002 | CHEMBL5278485 | N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide | n/a | |
| 81 | Q96RI1_YT3 | YT3 | n/a | 168049 | n/a | YTTRIUM (III) ION | n/a | |
| 82 | Q96RI1_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 83 | Q96RI1_T73 | T73 | n/a | 1798664 | n/a | (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxybenzoate | n/a | |
| 84 | Q96RI1_LNL | LNL | DB00132 | 5280934 | CHEMBL8739 | alpha-Linolenic acid | agonist | |
| 85 | Q96RI1_DB01586 | n/a | DB01586 | n/a | n/a | Ursodeoxycholic acid | partial agonist | EC50(nM) = 50000.0 |
| 86 | Q96RI1_FOH | FOH | DB02509 | 1549107 | CHEMBL1232800 | Farnesol | agonist | |
| 87 | Q96RI1_DB02545 | n/a | DB02545 | n/a | n/a | Fexaramine | inhibitor | Kd(nM) = 1220000.0 EC50(nM) = 25.0 |
| 88 | Q96RI1_CHD | CHD | DB02659 | 221493 | CHEMBL205596 | Cholic Acid | n/a | EC50(nM) = 45000.0 |
| 89 | Q96RI1_DXC | DXC | DB03619 | 222528 | CHEMBL406393 | Deoxycholic acid | n/a | |
| 90 | Q96RI1_TCH | TCH | DB04348 | 6675 | CHEMBL224867 | Taurocholic acid | n/a | |
| 91 | Q96RI1_ACD | ACD | DB04557 | 444899 | CHEMBL15594 | Arachidonic Acid | ligand | |
| 92 | Q96RI1_CHC | CHC | DB05990 | 447715 | CHEMBL566315 | Obeticholic acid | agonist | |
| 93 | Q96RI1_DB16255 | n/a | DB16255 | n/a | n/a | Nidufexor | agonist |