Gene name: CRBN
Protein name: Protein cereblon
List of molecules and drugs that interact with protein Q96SW2
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q96SW2_85C | 85C | n/a | 121225589 | n/a | 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea | n/a | |
| 2 | Q96SW2_8W7 | 8W7 | DB12101 | 67335295 | CHEMBL3989927 | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione | inhibitor | |
| 3 | Q96SW2_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 4 | Q96SW2_EF2 | EF2 | n/a | 92142 | CHEMBL426123 | S-Thalidomide | n/a | |
| 5 | Q96SW2_F4U | F4U | n/a | 44250311 | CHEMBL560448 | 2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione | n/a | |
| 6 | Q96SW2_LVY | LVY | n/a | 12044976 | n/a | S-Lenalidomide | n/a | |
| 7 | Q96SW2_LWK | LWK | n/a | 166638108 | n/a | (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione | n/a | |
| 8 | Q96SW2_QFC | QFC | DB17584 | 137379043 | CHEMBL4648616 | Mezigdomide | n/a | |
| 9 | Q96SW2_RN3 | RN3 | n/a | 137349957 | n/a | methyl {(6S)-4-(4-chlorophenyl)-2-[(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)carbamoyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl}acetate | n/a | |
| 10 | Q96SW2_RN6 | RN6 | n/a | 137349958 | n/a | 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)acetamide | n/a | |
| 11 | Q96SW2_RN9 | RN9 | n/a | 155920525 | n/a | 3-[3-[[1-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(oxidanylidene)pyrrol-3-yl]amino]phenyl]-~{N}-(3-chloranyl-4-methyl-phenyl)propanamide | n/a | |
| 12 | Q96SW2_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 13 | Q96SW2_V4M | V4M | n/a | 155289272 | n/a | 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide | n/a | |
| 14 | Q96SW2_VP9 | VP9 | n/a | 168429809 | n/a | 4-azanyl-2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-7-methoxy-isoindole-1,3-dione | n/a | |
| 15 | Q96SW2_Y70 | Y70 | n/a | 9965330 | CHEMBL2093113 | S-Pomalidomide | n/a | |
| 16 | Q96SW2_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 17 | Q96SW2_DB00480 | n/a | DB00480 | n/a | n/a | Lenalidomide | inhibitor | Ki(nM) = 1490.0 IC50(nM) = 390.0 |
| 18 | Q96SW2_DB01041 | n/a | DB01041 | n/a | n/a | Thalidomide | inhibitor | Ki(nM) = 1800.0 IC50(nM) = 1490.0 Kd(nM) = 1000.0 |
| 19 | Q96SW2_DB08910 | n/a | DB08910 | n/a | n/a | Pomalidomide | inhibitor | Ki(nM) = 3300.0 IC50(nM) = 83.0 Kd(nM) = 1000.0 |