Gene name: EPAS1
Protein name: Endothelial PAS domain-containing
List of molecules and drugs that interact with protein Q99814
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q99814_018 | 018 | n/a | 43805017 | n/a | 2-nitro-N-(thiophen-3-ylmethyl)-4-(trifluoromethyl)aniline | n/a | |
| 2 | Q99814_020 | 020 | n/a | 4080866 | n/a | N-(furan-2-ylmethyl)-2-nitro-4-(trifluoromethyl)aniline | n/a | |
| 3 | Q99814_0X3 | 0X3 | n/a | 70697712 | CHEMBL2311933 | N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine | n/a | |
| 4 | Q99814_0XB | 0XB | n/a | 2836648 | CHEMBL2311962 | N-(3-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine | n/a | |
| 5 | Q99814_2XY | 2XY | n/a | 12318718 | n/a | N-[2-nitro-4-(trifluoromethyl)phenyl]morpholin-4-amine | n/a | |
| 6 | Q99814_43L | 43L | n/a | 51551597;136075559; | CHEMBL3597698 | (5S,7R)-5,7-bis(3-bromophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine | n/a | |
| 7 | Q99814_79A | 79A | DB16055 | 91754484 | CHEMBL4173075 | 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile | inhibitor | |
| 8 | Q99814_86D | 86D | n/a | 91663289 | CHEMBL4165848 | 3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile | n/a | |
| 9 | Q99814_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 10 | Q99814_FO7 | FO7 | n/a | 122506316 | CHEMBL4172344 | {2-bromo-3-(3-chloro-5-fluorophenoxy)-6-[(difluoromethyl)sulfonyl]phenyl}methanol | n/a | |
| 11 | Q99814_FOJ | FOJ | n/a | 91810395 | CHEMBL4175320 | 3-{[(3R)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-2,3-dihydro-1H-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile | n/a | |
| 12 | Q99814_FOV | FOV | n/a | 134821994 | CHEMBL4168682 | N-(3-chloro-5-fluorophenyl)-2-nitro-4-[(trifluoromethyl)sulfonyl]aniline | n/a | |
| 13 | Q99814_PE8 | PE8 | n/a | 78798 | n/a | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL | n/a | |
| 14 | Q99814_UKJ | UKJ | n/a | 155920126 | n/a | 1-(3-bromo-5-fluorophenoxy)-4-[(difluoromethyl)sulfonyl]-2-nitrobenzene | n/a | |
| 15 | Q99814_ULD | ULD | n/a | n/a | n/a | cis-3-({(1S)-7-[dihydroxy(trifluoromethyl)-lambda~4~-sulfanyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)cyclobutane-1-carbonitrile | n/a | |
| 16 | Q99814_ULG | ULG | n/a | 122506276 | n/a | (1R)-4-(3,5-difluorophenoxy)-7-(trifluoromethyl)-2,3-dihydro-1H-inden-1-ol | n/a | |
| 17 | Q99814_ULM | ULM | n/a | 122541545 | n/a | (6R,7S)-4-[(3,3-difluorocyclobutyl)oxy]-6-fluoro-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol | n/a | |
| 18 | Q99814_ULS | ULS | n/a | 155920127 | n/a | 3-fluoro-5-{[(7R)-7-hydroxy-1-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-4-yl]oxy}benzonitrile | n/a | |
| 19 | Q99814_UXU | UXU | n/a | 152078964 | CHEMBL4639113 | (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol | n/a | |
| 20 | Q99814_UY3 | UY3 | n/a | 151898965 | CHEMBL5439202 | (4~{S})-1-[3,5-bis(fluoranyl)phenyl]-5,5-bis(fluoranyl)-3-methylsulfonyl-6,7-dihydro-4~{H}-2-benzothiophen-4-ol | n/a | |
| 21 | Q99814_UYF | UYF | n/a | 156405989 | CHEMBL5422094 | (4~{S})-1-cyclohexyloxy-5,5-bis(fluoranyl)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol | n/a | |
| 22 | Q99814_A1Z | A1Z | DB12255 | 23634441;152781920; | CHEMBL3646221 | Vadadustat | stabilization | |
| 23 | Q99814_72Q | 72Q | DB15463 | 117947097 | CHEMBL4585668 | Belzutifan | inhibitor |