Gene name: HDAC8
Protein name: Histone deacetylase 8
List of molecules and drugs that interact with protein Q9BY41
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Q9BY41_0DI | 0DI | n/a | 53249967 | CHEMBL1812334 | (2R)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one | n/a | ||
| 2 | Q9BY41_1DI | 1DI | n/a | 53357987 | CHEMBL1812335 | (2R)-2-amino-3-(2,4-dichlorophenyl)-1-(1,3-dihydro-2H-isoindol-2-yl)propan-1-one | n/a | ||
| 3 | Q9BY41_5YA | 5YA | n/a | 17748273 | CHEMBL156887 | 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide | n/a | ||
| 4 | Q9BY41_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | ||
| 5 | Q9BY41_AGE | AGE | DB07350 | 10379137 | CHEMBL12760 | (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide | n/a | ||
| 6 | Q9BY41_B3N | B3N | DB02565 | 3994 | CHEMBL140000 | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide | n/a | ||
| 7 | Q9BY41_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | ||
| 8 | Q9BY41_C7 | C7 | n/a | 146014938 | n/a | N-{2-[3-(hydroxyamino)-3-oxopropyl]phenyl}-3-(trifluoromethyl)benzamide | n/a | ||
| 9 | Q9BY41_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | ||
| 10 | Q9BY41_CO | CO | n/a | 104729 | n/a | COBALT (II) ION | n/a | ||
| 11 | Q9BY41_CRI | CRI | DB07586 | 5287979 | n/a | 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE | n/a | ||
| 12 | Q9BY41_DIO | DIO | DB03316 | 31275 | CHEMBL453716 | 1,4-DIETHYLENE DIOXIDE | n/a | ||
| 13 | Q9BY41_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | ||
| 14 | Q9BY41_FE2 | FE2 | n/a | 27284 | n/a | FE (II) ION | n/a | ||
| 15 | Q9BY41_GGG | GGG | n/a | 11161;6994044; | CHEMBL54278 | glycylglycylglycine | n/a | ||
| 16 | Q9BY41_GOK | GOK | DB12985 | 11538455 | CHEMBL2105763 | 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide | n/a | ||
| 17 | Q9BY41_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | ||
| 18 | Q9BY41_IMD | IMD | DB03366 | 444234;4434133;21983501; | n/a | IMIDAZOLE | n/a | ||
| 19 | Q9BY41_K | K | n/a | 813 | CHEMBL1233793 | POTASSIUM ION | n/a | ||
| 20 | Q9BY41_L6G | L6G | n/a | 42612743 | CHEMBL3593407 | (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3,17-dithia-7,10,14,19,20-pentaazatricyclo[14.2.1.1~2,5~]icosa-1(18),2(20),16(19)-triene-6,9,13-trione | n/a | ||
| 21 | Q9BY41_L7G | L7G | n/a | 91667421 | CHEMBL3593415 | (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,17,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione | n/a | ||
| 22 | Q9BY41_L8G | L8G | n/a | 91667420 | CHEMBL3593413 | (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,20,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione | n/a | ||
| 23 | Q9BY41_M7Y | M7Y | n/a | 146014939 | n/a | (2E)-3-[2-(3-cyclopentyl-5,5-dimethyl-2-oxoimidazolidin-1-yl)phenyl]-N-hydroxyprop-2-enamide | n/a | ||
| 24 | Q9BY41_M8G | M8G | n/a | 122514056 | n/a | N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide | n/a | ||
| 25 | Q9BY41_MCM | MCM | DB08168 | 92249 | CHEMBL270672 | 7-AMINO-4-METHYL-CHROMEN-2-ONE | n/a | ||
| 26 | Q9BY41_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | ||
| 27 | Q9BY41_MN | MN | n/a | 27854 | n/a | MANGANESE (II) ION | n/a | ||
| 28 | Q9BY41_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | ||
| 29 | Q9BY41_NHB | NHB | DB02917 | 449096 | n/a | N-HYDROXY-4-(METHYL{[5-(2-PYRIDINYL)-2-THIENYL]SULFONYL}AMINO)BENZAMIDE | n/a | ||
| 30 | Q9BY41_P6G | P6G | n/a | 17472 | CHEMBL1235082 | HEXAETHYLENE GLYCOL | n/a | ||
| 31 | Q9BY41_SHH | SHH | DB02546 | 5311 | CHEMBL98 | OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE | n/a | inhibitor | Ki(nM) = 173.0 IC50(nM) = 1.0 Kd(nM) = 580.0 |
| 32 | Q9BY41_TSN | TSN | DB04297 | 444732 | CHEMBL99 | TRICHOSTATIN A | n/a | Ki(nM) = 45.0 IC50(nM) = 70.1 | |
| 33 | Q9BY41_V5X | V5X | n/a | 16750122 | n/a | (2R)-N~8~-HYDROXY-2-{[(5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETYL]AMINO}-N~1~-[2-(2-PHENYL-1H-INDOL-3-YL)ETHYL]OCTANEDIAMIDE | n/a | ||
| 34 | Q9BY41_XCH | XCH | n/a | 568416 | CHEMBL1526649 | Droxinostat | n/a | ||
| 35 | Q9BY41_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | ||
| 36 | Q9BY41_DB01592 | n/a | DB01592 | n/a | n/a | Iron | cofactor | ||
| 37 | Q9BY41_DB01593 | n/a | DB01593 | n/a | n/a | Zinc | cofactor | ||
| 38 | Q9BY41_DB14487 | n/a | DB14487 | n/a | n/a | Zinc acetate | n/a | ||
| 39 | Q9BY41_DB14488 | n/a | DB14488 | n/a | n/a | Ferrous gluconate | n/a | ||
| 40 | Q9BY41_DB14489 | n/a | DB14489 | n/a | n/a | Ferrous succinate | n/a | ||
| 41 | Q9BY41_DB14490 | n/a | DB14490 | n/a | n/a | Ferrous ascorbate | n/a | ||
| 42 | Q9BY41_DB14491 | n/a | DB14491 | n/a | n/a | Ferrous fumarate | n/a | ||
| 43 | Q9BY41_DB14501 | n/a | DB14501 | n/a | n/a | Ferrous glycine sulfate | n/a | ||
| 44 | Q9BY41_DB14533 | n/a | DB14533 | n/a | n/a | Zinc chloride | cofactor |