Gene name: TLR8
Protein name: Toll-like receptor 8
List of molecules and drugs that interact with protein Q9NR97
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q9NR97_06S | 06S | n/a | n/a | n/a | O-[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-({[(S)-({(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-[(thiophosphonooxy)methyl]tetrahydrofuran-3-yl}oxy)(sulfanyl)phosphoryl]oxy}methyl)-4-hydroxytetrahydrofuran-3-yl] dihydrogen (S)-phosphorothioate | n/a | |
| 2 | Q9NR97_7VC | 7VC | n/a | 135567383 | CHEMBL4790706 | 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol | n/a | |
| 3 | Q9NR97_7VF | 7VF | n/a | 135567366 | CHEMBL5176610 | 4-(3-methyl-4-oxidanyl-phenyl)quinolin-7-ol | n/a | |
| 4 | Q9NR97_7VL | 7VL | n/a | 135567384 | CHEMBL5413646 | 4-(7-chloranylquinolin-4-yl)-2-methyl-phenol | n/a | |
| 5 | Q9NR97_BU3 | BU3 | n/a | 225936 | n/a | (R,R)-2,3-BUTANEDIOL | n/a | |
| 6 | Q9NR97_C09 | C09 | n/a | 11579618 | CHEMBL4081845 | 2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine | n/a | |
| 7 | Q9NR97_CU8 | CU8 | n/a | 15042086 | CHEMBL4553089 | 7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 8 | Q9NR97_D80 | D80 | n/a | 10421816 | CHEMBL5430530 | 2-butyl[1,3]oxazolo[4,5-c]quinolin-4-amine | n/a | |
| 9 | Q9NR97_D87 | D87 | n/a | 72771075 | CHEMBL2419475 | 2-butylfuro[2,3-c]quinolin-4-amine | n/a | |
| 10 | Q9NR97_DY3 | DY3 | n/a | 146037590 | CHEMBL4519240 | 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol | n/a | |
| 11 | Q9NR97_FMT | FMT | DB01942 | 284;18971002; | CHEMBL116736 | FORMIC ACID | n/a | |
| 12 | Q9NR97_GD0 | GD0 | n/a | 155461196 | n/a | 1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol | n/a | |
| 13 | Q9NR97_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 14 | Q9NR97_HB2 | HB2 | n/a | 21470208 | CHEMBL1082983 | 1-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol | n/a | |
| 15 | Q9NR97_I5B | I5B | n/a | 162679119 | CHEMBL5081397 | (5-methoxy-6-pyridin-4-yl-1~{H}-indazol-3-yl)-(4-methylpiperazin-1-yl)methanone | n/a | |
| 16 | Q9NR97_I5N | I5N | n/a | 162679118 | CHEMBL5091113 | 5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-~{N}-[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]-1~{H}-indazol-3-amine | n/a | |
| 17 | Q9NR97_I6A | I6A | n/a | 162679117 | CHEMBL5080083 | 5-methoxy-6-pyridin-4-yl-1~{H}-indole | n/a | |
| 18 | Q9NR97_IDQ | IDQ | n/a | 52945312 | CHEMBL1271706 | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine | n/a | |
| 19 | Q9NR97_JRI | JRI | n/a | 118006889 | n/a | (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide | n/a | |
| 20 | Q9NR97_L07 | L07 | n/a | 10198719 | CHEMBL512901 | 2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine | n/a | |
| 21 | Q9NR97_M0A | M0A | n/a | 52944297 | CHEMBL1271705 | 1-[[3-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine | n/a | |
| 22 | Q9NR97_M4D | M4D | n/a | 121231448 | CHEMBL3622853 | 5-(4-azanylbutyl)-3-pentyl-quinolin-2-amine | n/a | |
| 23 | Q9NR97_M8D | M8D | n/a | 121231447 | CHEMBL3622844 | 5-[[3-(aminomethyl)phenyl]methyl]-3-pentyl-quinolin-2-amine | n/a | |
| 24 | Q9NR97_MAN | MAN | n/a | 185698 | CHEMBL365590 | alpha-D-mannopyranose | n/a | |
| 25 | Q9NR97_MBL | MBL | n/a | 122172809 | CHEMBL4803538 | 1-pentyl-4-phenyl-imidazol-2-amine | n/a | |
| 26 | Q9NR97_MES | MES | DB03814 | 78165;4478249; | CHEMBL1234276 | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | n/a | |
| 27 | Q9NR97_NAG | NAG | DB00141 | 24139 | CHEMBL447878 | 2-acetamido-2-deoxy-beta-D-glucopyranose | n/a | |
| 28 | Q9NR97_O0W | O0W | n/a | 153835384 | CHEMBL4634366 | 5-methyl-7-(7-methyl-2-piperidin-4-yl-indazol-5-yl)furo[3,2-c]pyridin-4-one | n/a | |
| 29 | Q9NR97_QLH | QLH | DB16501 | 129240620 | CHEMBL4802159 | 5-[(3~{R},5~{S})-3-azanyl-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile | n/a | |
| 30 | Q9NR97_QSM | QSM | n/a | 134230898 | n/a | 2-(3,4-dimethoxyphenyl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole | n/a | |
| 31 | Q9NR97_RQY | RQY | n/a | 134329228 | CHEMBL5201891 | 2-(2,6-dimethylpyridin-4-yl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole | n/a | |
| 32 | Q9NR97_RX8 | RX8 | DB06530 | 159603 | CHEMBL383322 | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol | modulator | |
| 33 | Q9NR97_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 34 | Q9NR97_U57 | U57 | n/a | 122585078 | CHEMBL4594258 | (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol | n/a | |
| 35 | Q9NR97_UCG | UCG | n/a | 86346634;135566941; | n/a | 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate) | n/a | |
| 36 | Q9NR97_UPT | UPT | n/a | n/a | n/a | 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione | n/a | |
| 37 | Q9NR97_URI | URI | DB02745 | 6029 | CHEMBL100259 | URIDINE | n/a | |
| 38 | Q9NR97_XG1 | XG1 | n/a | 66958698 | CHEMBL5400758 | 2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine | n/a | |
| 39 | Q9NR97_YHG | YHG | n/a | n/a | n/a | (3~{S})-~{N}-[4-[[5-(1,6-dimethylpyrazolo[3,4-b]pyridin-4-yl)-3-methyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-1-yl]methyl]-1-bicyclo[2.2.2]octanyl]morpholine-3-carboxamide | n/a | |
| 40 | Q9NR97_6T0 | 6T0 | DB00724 | 57469 | CHEMBL1282 | Imiquimod | agonist | EC50(nM) = 270000.0 |
| 41 | Q9NR97_DB16324 | n/a | DB16324 | n/a | n/a | Selgantolimod | agonist | |
| 42 | Q9NR97_DB16580 | n/a | DB16580 | n/a | n/a | Afimetoran | antagonist |