Gene name: IRAK4
Protein name: Interleukin-1 receptor-associated kinase
List of molecules and drugs that interact with protein Q9NWZ3
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q9NWZ3_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | n/a | |
| 2 | Q9NWZ3_42P | 42P | n/a | 58570790 | n/a | (1R,2S,3R,5R)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | n/a | |
| 3 | Q9NWZ3_4GD | 4GD | n/a | 1247796 | CHEMBL1439445 | N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 4 | Q9NWZ3_4GF | 4GF | n/a | 68357894 | CHEMBL3586508 | N-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 5 | Q9NWZ3_4S1 | 4S1 | n/a | 91844450 | CHEMBL3403447 | (1R,2S,3R,5R)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | n/a | |
| 6 | Q9NWZ3_4S2 | 4S2 | n/a | 135567024 | CHEMBL3622183 | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3H)-one | n/a | |
| 7 | Q9NWZ3_4S3 | 4S3 | n/a | 135567025 | CHEMBL3622518 | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3R)-piperidin-3-ylamino]pyrimidin-4(3H)-one | n/a | |
| 8 | Q9NWZ3_6QX | 6QX | n/a | n/a | CHEMBL3361252 | ~{N}1-(7,8-dihydro-6~{H}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{N}4,~{N}4-dimethyl-cyclohexane-1,4-diamine | n/a | |
| 9 | Q9NWZ3_6QY | 6QY | n/a | n/a | CHEMBL4089379 | ~{N}4,~{N}4-dimethyl-~{N}1-[5-(oxan-4-yl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | n/a | |
| 10 | Q9NWZ3_6QZ | 6QZ | n/a | n/a | CHEMBL4078222 | (3~{a}~{R},7~{a}~{S})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | n/a | |
| 11 | Q9NWZ3_6R0 | 6R0 | n/a | n/a | CHEMBL4102501 | (3~{a}~{S},7~{a}~{R})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | n/a | |
| 12 | Q9NWZ3_6R1 | 6R1 | n/a | n/a | CHEMBL4064608 | ~{N}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 13 | Q9NWZ3_6YD | 6YD | n/a | 73442848 | CHEMBL3353206 | ~{N}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide | n/a | |
| 14 | Q9NWZ3_6YE | 6YE | n/a | 121493987 | CHEMBL4459066 | ~{N}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 15 | Q9NWZ3_76P | 76P | n/a | n/a | CHEMBL4079234 | ~{N},~{N}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | n/a | |
| 16 | Q9NWZ3_76Q | 76Q | n/a | 126961336 | CHEMBL4094657 | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | n/a | |
| 17 | Q9NWZ3_8BV | 8BV | n/a | 2728161 | CHEMBL4093989 | 2-[(propan-2-yl)oxy]benzamide | n/a | |
| 18 | Q9NWZ3_8BY | 8BY | n/a | 126970816 | CHEMBL4086222 | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | n/a | |
| 19 | Q9NWZ3_8C1 | 8C1 | n/a | 126573681 | CHEMBL4061493 | 4-{[(3R)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | n/a | |
| 20 | Q9NWZ3_8CD | 8CD | n/a | 118414671 | CHEMBL4092338 | 1-{[(2S)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide | n/a | |
| 21 | Q9NWZ3_8CG | 8CG | DB15143 | 118414016 | CHEMBL4081711 | 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | n/a | |
| 22 | Q9NWZ3_9YS | 9YS | n/a | 131704459 | CHEMBL4079743 | 6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino}-N-methylpyridine-3-carboxamide | n/a | |
| 23 | Q9NWZ3_9YY | 9YY | n/a | 137348875 | CHEMBL4098698 | 4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]pyridine-3-carboxamide | n/a | |
| 24 | Q9NWZ3_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 25 | Q9NWZ3_B4U | B4U | n/a | 163201217 | CHEMBL5190750 | 6-[(2~{S})-2-fluoranylpropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | n/a | |
| 26 | Q9NWZ3_B6I | B6I | n/a | 163201216 | CHEMBL5174529 | 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | n/a | |
| 27 | Q9NWZ3_B7R | B7R | n/a | 163201218 | CHEMBL5191035 | 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one | n/a | |
| 28 | Q9NWZ3_B8I | B8I | n/a | n/a | CHEMBL5184305 | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]-5-oxidanylidene-pyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | n/a | |
| 29 | Q9NWZ3_BME | BME | DB03345 | 1567 | CHEMBL254951 | BETA-MERCAPTOETHANOL | n/a | |
| 30 | Q9NWZ3_CA | CA | n/a | 271 | n/a | CALCIUM ION | n/a | |
| 31 | Q9NWZ3_CJN | CJN | n/a | n/a | CHEMBL4276955 | ~{N}4,~{N}4-dimethyl-~{N}1-(5-propan-2-ylpyrrolo[3,2-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | n/a | |
| 32 | Q9NWZ3_CJQ | CJQ | n/a | n/a | CHEMBL3361254 | 2-[(3~{R})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide | n/a | |
| 33 | Q9NWZ3_CJT | CJT | n/a | n/a | CHEMBL4279192 | 4-[4-[[4-(dimethylamino)cyclohexyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide | n/a | |
| 34 | Q9NWZ3_CKN | CKN | n/a | n/a | CHEMBL4293607 | (3~{R})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide | n/a | |
| 35 | Q9NWZ3_CO | CO | n/a | 104729 | n/a | COBALT (II) ION | n/a | |
| 36 | Q9NWZ3_DL1 | DL1 | n/a | 44449334 | CHEMBL256713 | N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide | n/a | |
| 37 | Q9NWZ3_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 38 | Q9NWZ3_EXF | EXF | n/a | 90155351 | CHEMBL4634922 | N-[(2R)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide | n/a | |
| 39 | Q9NWZ3_FJ0 | FJ0 | DB18060 | 118224491 | CHEMBL4783351 | 2-(2-methylpyridin-4-yl)-N-[2-morpholin-4-yl-5-[(3R)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | n/a | |
| 40 | Q9NWZ3_FJ9 | FJ9 | n/a | 71542383 | CHEMBL4789126 | N-(2-morpholin-4-yl-1,3-benzoxazol-6-yl)-6-pyridin-4-yl-pyridine-2-carboxamide | n/a | |
| 41 | Q9NWZ3_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 42 | Q9NWZ3_J87 | J87 | n/a | 137331515 | n/a | N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | n/a | |
| 43 | Q9NWZ3_J8A | J8A | n/a | 137332069 | n/a | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | n/a | |
| 44 | Q9NWZ3_JX4 | JX4 | n/a | 145946027 | n/a | 6-[7-methoxy-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-N-[(3R)-pyrrolidin-3-yl]pyridin-2-amine | n/a | |
| 45 | Q9NWZ3_K1E | K1E | n/a | n/a | CHEMBL4582624 | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | n/a | |
| 46 | Q9NWZ3_K1H | K1H | n/a | n/a | CHEMBL4455718 | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | n/a | |
| 47 | Q9NWZ3_KFD | KFD | n/a | 135121936 | n/a | N-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | n/a | |
| 48 | Q9NWZ3_LRS | LRS | n/a | 138376590 | CHEMBL4483477 | N-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1H-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 49 | Q9NWZ3_LS7 | LS7 | n/a | 129284442 | CHEMBL4473269 | N-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 50 | Q9NWZ3_LSV | LSV | n/a | 129284345 | CHEMBL4466517 | N-[(2R)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 51 | Q9NWZ3_LTY | LTY | n/a | 58056341 | CHEMBL3950656 | N-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 52 | Q9NWZ3_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 53 | Q9NWZ3_N9Z | N9Z | n/a | 154815577 | CHEMBL5179237 | 2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile | n/a | |
| 54 | Q9NWZ3_NB5 | NB5 | n/a | 154815578 | CHEMBL5270903 | 7-fluoranyl-~{N}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | n/a | |
| 55 | Q9NWZ3_NBK | NBK | n/a | 154815576 | CHEMBL5288931 | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{N}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | n/a | |
| 56 | Q9NWZ3_NBW | NBW | n/a | 154815579 | CHEMBL5275280 | ~{N},~{N}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | n/a | |
| 57 | Q9NWZ3_O06 | O06 | n/a | 138656922 | CHEMBL5405768 | ~{N}-[3-methyl-2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | n/a | |
| 58 | Q9NWZ3_O6X | O6X | n/a | 118173077 | CHEMBL5426360 | ~{N}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{R})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | n/a | |
| 59 | Q9NWZ3_QL7 | QL7 | n/a | 129284334 | CHEMBL4475494 | N-{2-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 60 | Q9NWZ3_R7S | R7S | n/a | 90155396 | CHEMBL4642013 | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | n/a | |
| 61 | Q9NWZ3_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 62 | Q9NWZ3_XPY | XPY | n/a | 122181630 | CHEMBL3590478 | 5-{[(1R,2S)-2-aminocyclohexyl]amino}-N-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 63 | Q9NWZ3_SO9 | SO9 | n/a | 164607234 | CHEMBL5185144 | (1S,2S,3R,4R)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide | n/a | |
| 64 | Q9NWZ3_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 65 | Q9NWZ3_T12 | T12 | DB08590 | 11987888 | CHEMBL1236126 | 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE | n/a | Ki(nM) = 1.2 |
| 66 | Q9NWZ3_T20 | T20 | n/a | 10226185 | CHEMBL3735719 | 3-nitro-N-[1-phenyl-5-(piperidin-1-ylmethyl)-1H-benzimidazol-2-yl]benzamide | n/a | |
| 67 | Q9NWZ3_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |