Gene name: ALK
Protein name: ALK tyrosine kinase
List of molecules and drugs that interact with protein Q9UM73
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q9UM73_0JF | 0JF | n/a | 56596558 | CHEMBL2023534 | (3S)-N-(4-methylbenzyl)-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide | n/a | |
| 2 | Q9UM73_0US | 0US | n/a | n/a | CHEMBL2172322 | N-{1-[cis-4-(hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)-1H-benzimidazol-2-yl}-3-(prop-2-en-1-ylsulfamoyl)benzamide | n/a | |
| 3 | Q9UM73_0UU | 0UU | n/a | n/a | CHEMBL2172323 | methyl cis-4-[2-(benzoylamino)-6-(piperidin-1-ylmethyl)-1H-benzimidazol-1-yl]cyclohexanecarboxylate | n/a | |
| 4 | Q9UM73_0UV | 0UV | n/a | n/a | CHEMBL2172308 | 4-fluoro-N-{(2E)-6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[cis-4-(propan-2-ylcarbamoyl)cyclohexyl]-1,3-dihydro-2H-benzimidazol-2-ylidene}benzamide | n/a | |
| 5 | Q9UM73_25J | 25J | n/a | 67463531 | n/a | 4-(6-amino-5-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1H-isoindol-1-one | n/a | |
| 6 | Q9UM73_34Y | 34Y | n/a | 119025617 | CHEMBL3810133 | 4-[(4-methylpiperazin-1-yl)methyl]-N-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1H-pyrazol-5-yl}benzamide | n/a | |
| 7 | Q9UM73_3DK | 3DK | n/a | 71604335 | CHEMBL2418761 | 3-[1-(2,5-difluorobenzyl)-1H-pyrazol-4-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | n/a | |
| 8 | Q9UM73_3U9 | 3U9 | n/a | 67467779 | CHEMBL3286808 | 3-[(1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1H-1,2,3-triazol-5-yl)pyridin-2-amine | n/a | |
| 9 | Q9UM73_45Q | 45Q | n/a | 119025618 | CHEMBL3809012 | N-[3-(4-amino-3-methylphenyl)-1H-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | n/a | |
| 10 | Q9UM73_4LO | 4LO | n/a | 25160544 | CHEMBL4798141 | N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine | n/a | |
| 11 | Q9UM73_4MK | 4MK | DB09063 | 57379345 | CHEMBL2403108 | 5-chloro-N~2~-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine | antagonist | |
| 12 | Q9UM73_571 | 571 | n/a | 49866522 | n/a | 5-[(2R)-2-hydroxy-2-phenylacetyl]-3-({[4-(4-methylpiperazin-1-yl)phenyl]carbonyl}amino)-1,6-dihydropyrrolo[3,4-c]pyrazol-5-ium | n/a | |
| 13 | Q9UM73_5P8 | 5P8 | DB12130 | 71731823 | CHEMBL3286830 | (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | inhibitor | |
| 14 | Q9UM73_6GY | 6GY | DB12267 | 68165256 | CHEMBL3545311 | 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | inhibitor | |
| 15 | Q9UM73_6YL | 6YL | n/a | 90644195 | CHEMBL3286810 | 2-[(1~{R})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl)pyridin-3-yl]oxyethyl]-4-fluoranyl-~{N},~{N}-dimethyl-benzamide | n/a | |
| 16 | Q9UM73_729 | 729 | n/a | 60198892 | CHEMBL2386796 | N-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1H-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | n/a | |
| 17 | Q9UM73_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 18 | Q9UM73_AWF | AWF | n/a | 54588490 | CHEMBL3128064 | 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol | n/a | |
| 19 | Q9UM73_AWJ | AWJ | n/a | 137348958 | n/a | (2R)-2-[5-(6-amino-5-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol | n/a | |
| 20 | Q9UM73_COM | COM | DB09110 | 598 | CHEMBL1098319 | 1-THIOETHANESULFONIC ACID | n/a | |
| 21 | Q9UM73_CZ4 | CZ4 | n/a | 118988436 | CHEMBL3604632 | 5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine | n/a | |
| 22 | Q9UM73_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 23 | Q9UM73_EMH | EMH | DB11363 | 49806720 | CHEMBL1738797 | 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | inhibitor | |
| 24 | Q9UM73_F8R | F8R | n/a | 155883012 | n/a | 2-(dimethylamino)-1-[5-methoxy-6-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-5H-pyrrolo[3,2-d]pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanone | n/a | |
| 25 | Q9UM73_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 26 | Q9UM73_GUI | GUI | n/a | 16038120 | CHEMBL509032 | 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE | n/a | |
| 27 | Q9UM73_GWH | GWH | n/a | 137349460 | n/a | 3-{(1R)-1-[2-(1,3-dihydro-2H-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}-5-[3-(methylsulfonyl)phenyl]pyridin-2-amine | n/a | |
| 28 | Q9UM73_HKJ | HKJ | n/a | 138105933 | CHEMBL4516124 | N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-1-(5-methyl-1H-pyrazol-3-yl)-3-[(oxetan-3-yl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-6-amine | n/a | |
| 29 | Q9UM73_I3K | I3K | n/a | 11351339 | CHEMBL3809422 | N-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amine | n/a | |
| 30 | Q9UM73_IV7 | IV7 | n/a | 90644193 | CHEMBL3286820 | (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one | n/a | |
| 31 | Q9UM73_J3Y | J3Y | n/a | 138105934 | CHEMBL4437605 | [6-{[(1S)-1-(5-fluoropyridin-2-yl)ethyl]amino}-1-(5-methyl-1H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl](morpholin-4-yl)methanone | n/a | |
| 32 | Q9UM73_J4M | J4M | n/a | 138105936 | CHEMBL4562879 | N-[(1S)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine | n/a | |
| 33 | Q9UM73_J99 | J99 | n/a | 73819548 | CHEMBL3286829 | (10R)-7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one | n/a | |
| 34 | Q9UM73_KVC | KVC | n/a | 89816720 | CHEMBL3286832 | (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20-tetrahydro-11,7-(azeno)pyrido[2',1':2,3]imidazo[4,5-h][2,5,11]benzoxadiazacyclotetradecine-14-carbonitrile | n/a | |
| 35 | Q9UM73_NRR | NRR | n/a | 164889288 | n/a | 3-(dimethylamino)-1-[3-[4-(4-methylpiperazin-1-yl)phenyl]-9~{H}-pyrido[2,3-b]indol-6-yl]prop-2-en-1-one | n/a | |
| 36 | Q9UM73_NZF | NZF | n/a | 53495177 | CHEMBL2023556 | (3S)-N-[3-(trifluoromethoxy)benzyl]-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide | n/a | |
| 37 | Q9UM73_OFG | OFG | n/a | 67462112 | CHEMBL3128074 | 3-[(1R)-1-[5-fluoranyl-2-(1,2,3-triazol-2-yl)phenyl]ethoxy]-5-(3-methyl-1H-pyrazol-4-yl)pyridin-2-amine | n/a | |
| 38 | Q9UM73_U4W | U4W | n/a | n/a | CHEMBL3805123 | N-[5-(3,5-DIFLUOROBENZYL)-1H-INDAZOL-3-YL]-2-[(4-HYDROXYCYCLOHEXYL)AMINO]-4-(4-METHYLPIPERAZIN-1-YL) BENZAMIDE | n/a | |
| 39 | Q9UM73_VGH | VGH | DB08865 | 11626560 | CHEMBL601719 | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine | inhibitor | |
| 40 | Q9UM73_VRM | VRM | n/a | 12707229 | CHEMBL5189272 | 3-(3-methyl-1H-pyrazol-5-yl)pyridine | n/a | |
| 41 | Q9UM73_VTA | VTA | n/a | 155295767 | n/a | 4-{[(1R,2R)-2-(2,4-difluorophenyl)cyclopropyl]oxy}-3-(5-methyl-1H-pyrazol-3-yl)benzonitrile | n/a | |
| 42 | Q9UM73_VTD | VTD | n/a | 15451749 | n/a | 3-(3-chlorophenyl)-5-methyl-1H-pyrazole | n/a | |
| 43 | Q9UM73_W47 | W47 | n/a | 155295766 | CHEMBL5198499 | 1-{(1S,2S)-1-(2,4-difluorophenyl)-2-[2-(3-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl}methanamine | n/a | |
| 44 | Q9UM73_YMX | YMX | DB11986 | 25141092 | CHEMBL1983268 | Entrectinib | inhibitor | |
| 45 | Q9UM73_YPW | YPW | n/a | 73819542 | CHEMBL3286812 | 2-[(1R)-1-{[3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl]oxy}ethyl]-4-fluoro-N-methylbenzamide | n/a | |
| 46 | Q9UM73_STU | STU | DB02010 | 44259 | CHEMBL388978 | STAUROSPORINE | n/a | |
| 47 | Q9UM73_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ATP | n/a | |
| 48 | Q9UM73_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 49 | Q9UM73_C6F | C6F | DB12141 | 49803313 | CHEMBL3301622 | Gilteritinib | inhibitor |