DrugDomain logoDrugDomain

4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile

P00519 — Tyrosine-protein kinase ABL1

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Attributes

UniProt ID
P00519
Protein Name
Tyrosine-protein kinase ABL1
Ligand Name
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
DrugBank ID
DB06616
PDB Ligand Accession
DB8
ChEMBL ID
CHEMBL288441
PubChem ID
5328940
InChIKey
UBPYILGKFZZVDX-UHFFFAOYSA-N
SMILES
CN1CCN(CC1)CCCOc2cc3c(cc2OC)c(c(cn3)C#N)Nc4cc(c(cc4Cl)Cl)OC
Drug Action
inhibitor
Affinity Metrics
ic50:0.5 nM
kd:0.029 nM