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7-ethyl-10-hydroxycamptothecin

P11387 — DNA topoisomerase 1

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Attributes

UniProt ID
P11387
Protein Name
DNA topoisomerase 1
Ligand Name
7-ethyl-10-hydroxycamptothecin
DrugBank ID
DB05482
PDB Ligand Accession
RS4
ChEMBL ID
CHEMBL837
PubChem ID
104842
InChIKey
FJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILES
CCc1c2cc(ccc2nc3c1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O
Drug Action
inhibitor
Affinity Metrics
ic50:1000 nM