N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide

P15056 — Serine/threonine-protein kinase B-raf

Attributes

UniProt ID

Protein Name

Serine/threonine-protein kinase B-raf

Ligand Name

N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide

DrugBank ID

PDB Ligand Accession

ChEMBL ID

PubChem ID

InChIKey

YZDJQTHVDDOVHR-UHFFFAOYSA-N

SMILES

CCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c2c[nH]c3c2cc(cn3)Cl)F

Drug Action

inhibitor

Affinity Metrics

ki:2.6 nM

ic50:13 nM

kd:100 nM