4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
P15056 — Serine/threonine-protein kinase B-raf
Attributes
UniProt ID
Protein Name
Serine/threonine-protein kinase B-raf
Ligand Name
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
DrugBank ID
PDB Ligand Accession
ChEMBL ID
PubChem ID
InChIKey
MLDQJTXFUGDVEO-UHFFFAOYSA-N
SMILES
CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl
Drug Action
inhibitor
Affinity Metrics
ki:22 nM
ic50:4.4 nM
kd:260 nM
ec50:3 nM