DrugDomain logoDrugDomain

4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide

P25101 — Endothelin-1 receptor

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Attributes

UniProt ID
P25101
Protein Name
Endothelin-1 receptor
Ligand Name
4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide
DrugBank ID
DB00559
PDB Ligand Accession
K86
ChEMBL ID
CHEMBL957
PubChem ID
104865
InChIKey
GJPICJJJRGTNOD-UHFFFAOYSA-N
SMILES
CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2c(c(nc(n2)c3ncccn3)OCCO)Oc4ccccc4OC
Drug Action
antagonist
Affinity Metrics
ki:6.5 nM
ic50:4.7 nM