8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione

P27487 — Dipeptidyl peptidase 4

Attributes

UniProt ID

Protein Name

Dipeptidyl peptidase 4

Ligand Name

8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione

DrugBank ID

PDB Ligand Accession

ChEMBL ID

PubChem ID

InChIKey

LTXREWYXXSTFRX-QGZVFWFLSA-N

SMILES

CC#CCn1c2c(nc1N3CCCC(C3)N)N(C(=O)N(C2=O)Cc4nc(c5ccccc5n4)C)C

Drug Action

inhibitor

Affinity Metrics

ic50:0.1 nM

kd:0.0066 nM

ec50:3.1 nM