DrugDomain logoDrugDomain

4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE

P49354 — Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

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Attributes

UniProt ID
P49354
Protein Name
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Ligand Name
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
DrugBank ID
DB07227
PDB Ligand Accession
778
ChEMBL ID
CHEMBL279433
PubChem ID
216454
InChIKey
JNUGFGAVPBYSHF-UHFFFAOYSA-N
SMILES
c1cc(cc(c1)Cl)N2CCN(CC2=O)Cc3cncn3Cc4ccc(cc4)C#N
Drug Action
modulator
Affinity Metrics
ic50:2 nM
ec50:6800 nM