1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one

Q06187 — Tyrosine-protein kinase BTK

Attributes

UniProt ID

Protein Name

Tyrosine-protein kinase BTK

Ligand Name

1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one

DrugBank ID

PDB Ligand Accession

ChEMBL ID

PubChem ID

InChIKey

XYFPWWZEPKGCCK-GOSISDBHSA-N

SMILES

C=CC(=O)N1CCCC(C1)n2c3c(c(n2)c4ccc(cc4)Oc5ccccc5)c(ncn3)N

Drug Action

inhibitor

Affinity Metrics

ki:4.8 nM

ic50:0.08 nM

kd:0.64 nM

ec50:5.8 nM