5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one

Q16539 — Mitogen-activated protein kinase 14

Attributes

UniProt ID

Protein Name

Mitogen-activated protein kinase 14

Ligand Name

5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one

DrugBank ID

PDB Ligand Accession

ChEMBL ID

PubChem ID

InChIKey

VEPKQEUBKLEPRA-UHFFFAOYSA-N

SMILES

c1cc(c(c(c1)Cl)C2=C3C=CC(=NN3C=NC2=O)Sc4ccc(cc4F)F)Cl

Drug Action

inhibitor

Affinity Metrics

ki:0.8 nM

ic50:9 nM

kd:2.8 nM