Ligand name: SPIRONOLACTONE
PDB ligand accession: SNL
DrugBank: DB00421
PubChem: 5833
ChEMBL: CHEMBL1393
InChI Key: LXMSZDCAJNLERA-ZHYRCANASA-N
SMILES: CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Lipids and lipid-like molecules
    • Class: Steroids and steroid derivatives
      • Subclass: Steroid lactones

List of proteins that are targets for DB00421

#	DrugDomain Data	UniProt Accession	Drug Action	Affinity data
1	P04278_SNL	P04278	n/a
2	P19099_SNL	P19099	n/a
3	O75469_SNL	O75469	agonist
4	P08235_SNL	P08235	antagonist	Ki(nM) = 2.323 IC50(nM) = 1.6
5	P10275_SNL	P10275	antagonist	Ki(nM) = 39.4 IC50(nM) = 48.0 EC50(nM) = 20000.0
6	P05093_SNL	P05093	n/a
7	P04150_SNL	P04150	antagonist	Ki(nM) = 32.6 IC50(nM) = 1400.0 EC50(nM) = 20000.0
8	P06401_SNL	P06401	agonist	Ki(nM) = 399.7 IC50(nM) = 650.0 EC50(nM) = 20000.0