O75460 ERN1_HUMAN
Gene name: ERN1
Protein name: Serine/threonine-protein kinase/endoribonuclease IRE1

List of molecules and drugs that interact with protein O75460

#	DrugDomain Data	PBD ligand	DrugBank Accession	PubChem	ChEMBL	Name	Drug action	Affinity data
1	O75460_3E4	3E4	n/a	n/a	CHEMBL3356007	N-{4-[(3-{2-[(trans-4-aminocyclohexyl)amino]pyrimidin-4-yl}pyridin-2-yl)oxy]-3-methylnaphthalen-1-yl}-2-chlorobenzenesulfonamide	n/a
2	O75460_4K7	4K7	n/a	73291790	n/a	(5R)-2-(3,4-dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro[4.5]decane-7-carboxamide	n/a
3	O75460_4L5	4L5	n/a	136664429	CHEMBL4554474	2-methoxy-4-[6-(propan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide	n/a
4	O75460_ADP	ADP	DB16833	6022	CHEMBL14830	ADENOSINE-5'-DIPHOSPHATE	n/a
5	O75460_BME	BME	DB03345	1567	CHEMBL254951	BETA-MERCAPTOETHANOL	n/a
6	O75460_CL	CL	n/a	312	n/a	CHLORIDE ION	n/a
7	O75460_CS	CS	n/a	104967	n/a	CESIUM ION	n/a
8	O75460_DTT	DTT	DB04447	439196	CHEMBL406270	2,3-DIHYDROXY-1,4-DITHIOBUTANE	n/a
9	O75460_EDO	EDO	n/a	174	CHEMBL457299	1,2-ETHANEDIOL	n/a
10	O75460_EPE	EPE	DB16872	23830;23831;3275884;	CHEMBL1232545	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	n/a
11	O75460_GOL	GOL	DB09462	753	CHEMBL692	GLYCEROL	n/a
12	O75460_GUK	GUK	n/a	137333976	n/a	6-chloranyl-3-(2~{H}-indazol-5-yl)-~{N}-propan-2-yl-imidazo[1,2-b]pyridazin-8-amine	n/a
13	O75460_GXK	GXK	n/a	137333978	CHEMBL4525939	6-chloranyl-~{N}-(cyclopropylmethyl)-3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-8-amine	n/a
14	O75460_MG	MG	n/a	888	n/a	MAGNESIUM ION	n/a
15	O75460_N8S	N8S	n/a	155899127	CHEMBL4752754	4-amino-N-(6-chloro-2-fluoro-3-{[(2-fluorophenyl)sulfonyl]amino}phenyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)quinazoline-8-carboxamide	n/a
16	O75460_N94	N94	n/a	155899129	CHEMBL4780489	4-amino-N-(6-chloro-2-fluoro-3-{[(pyrrolidin-1-yl)sulfonyl]amino}phenyl)quinazoline-8-carboxamide	n/a
17	O75460_N97	N97	n/a	n/a	CHEMBL4786638	4-[(trans-4-aminocyclohexyl)amino]-N-(6-chloro-3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)thieno[3,2-d]pyrimidine-7-carboxamide	n/a
18	O75460_NA	NA	n/a	923	n/a	SODIUM ION	n/a
19	O75460_PEG	PEG	n/a	8117	CHEMBL1235226	DI(HYDROXYETHYL)ETHER	n/a
20	O75460_PGE	PGE	DB02327	8172	CHEMBL1235259	TRIETHYLENE GLYCOL	n/a
21	O75460_QFV	QFV	n/a	118721244	CHEMBL3356009	2-chloro-N-(6-methyl-5-{[3-(2-{[(3S)-piperidin-3-yl]amino}pyrimidin-4-yl)pyridin-2-yl]oxy}naphthalen-1-yl)benzene-1-sulfonamide	n/a
22	O75460_SJG	SJG	n/a	135328813	n/a	ethyl ~{N}-[6-methyl-5-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamate	n/a
23	O75460_SJM	SJM	n/a	155289262	n/a	~{N}-[6-methyl-5-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]but-2-ynamide	n/a
24	O75460_SJS	SJS	n/a	155289264	n/a	4-[5-[2,6-bis(fluoranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-oxidanylpiperidin-1-yl)-1~{H}-pyrimidin-6-one	n/a
25	O75460_SJV	SJV	n/a	155289263	n/a	methyl ~{N}-[6-methyl-5-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamate	n/a
26	O75460_SO4	SO4	DB14546	1117	n/a	SULFATE ION	n/a
27	O75460_U4N	U4N	n/a	155925860	n/a	2,2,2-tris(fluoranyl)-~{N}-[4-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]ethanesulfonamide	n/a
28	O75460_STU	STU	DB02010	44259	CHEMBL388978	STAUROSPORINE	n/a
29	O75460_APJ	APJ	DB07382	42627755	CHEMBL1231018	N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine	inhibitor
30	O75460_2RC	2RC	DB12010	11671467	CHEMBL2103830	Fostamatinib	inhibitor