Gene name: FGFR1
Protein name: Fibroblast growth factor
List of molecules and drugs that interact with protein P11362
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | P11362_07J | 07J | DB11886 | 53235510 | CHEMBL1852688 | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea | inhibitor | |
| 2 | P11362_0S7 | 0S7 | n/a | 56973548 | CHEMBL2088089 | 5-bromo-N~4~-(3-methyl-1H-pyrazol-5-yl)-N~2~-[2-(pyridin-3-yl)ethyl]pyrimidine-2,4-diamine | n/a | |
| 3 | P11362_0S8 | 0S8 | n/a | 56973549 | CHEMBL2088093 | 5-bromo-N~4~-[3-(3-methoxypropyl)-1H-pyrazol-5-yl]-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | n/a | |
| 4 | P11362_0S9 | 0S9 | n/a | 56973550 | CHEMBL2088095 | 5-bromo-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-N~4~-[3-(2-phenylethyl)-1H-pyrazol-5-yl]pyrimidine-2,4-diamine | n/a | |
| 5 | P11362_2K5 | 2K5 | n/a | 24774737 | CHEMBL2088096 | N~4~-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | n/a | |
| 6 | P11362_2K7 | 2K7 | n/a | 24775639 | CHEMBL3109570 | N~4~-{3-[2-(3,4-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | n/a | |
| 7 | P11362_2M2 | 2M2 | n/a | 60154330 | CHEMBL2088100 | N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-N~4~-[5-(2-phenylethyl)-1H-pyrazol-3-yl]pyrimidine-2,4-diamine | n/a | |
| 8 | P11362_38O | 38O | DB05928 | 135398510 | CHEMBL522892 | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one | n/a | |
| 9 | P11362_3RH | 3RH | n/a | 51346202 | CHEMBL1738735 | (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine | n/a | |
| 10 | P11362_3ZC | 3ZC | DB11845 | 25031915 | CHEMBL2220486 | 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-N-methylnaphthalene-1-carboxamide | inhibitor | |
| 11 | P11362_42I | 42I | n/a | 137652911 | CHEMBL4095682 | N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]benzamide | n/a | |
| 12 | P11362_466 | 466 | n/a | 157049296 | CHEMBL5088013 | N-[6-(3-ethoxyphenyl)-1H-indazol-3-yl]benzamide | n/a | |
| 13 | P11362_47I | 47I | n/a | 157049297 | n/a | 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1H-indazol-6-yl]phenol | n/a | |
| 14 | P11362_4UT | 4UT | n/a | 91801169 | CHEMBL4063676 | 4-(4-ethylpiperazin-1-yl)-N-[6-(3-methoxyphenyl)-2H-indazol-3-yl]benzamide | n/a | |
| 15 | P11362_4Y0 | 4Y0 | n/a | 35532110 | n/a | 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide | n/a | |
| 16 | P11362_5SF | 5SF | DB12147 | 67462786 | CHEMBL3545376 | ~{N}'-(3,5-dimethoxyphenyl)-~{N}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{N}-propan-2-yl-ethane-1,2-diamine | inhibitor | |
| 17 | P11362_66T | 66T | DB12247 | 51039095 | CHEMBL3348846 | N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide | modulator | |
| 18 | P11362_8ZF | 8ZF | DB15102 | 86705695 | CHEMBL4297522 | 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one | inhibitor | |
| 19 | P11362_960 | 960 | n/a | 117796536 | n/a | 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridine | n/a | |
| 20 | P11362_9ES | 9ES | n/a | 137348810 | n/a | N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide | n/a | |
| 21 | P11362_9K5 | 9K5 | n/a | 15124200 | n/a | [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate | n/a | |
| 22 | P11362_9K8 | 9K8 | n/a | 137348832 | n/a | [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 4-ethyl-3-fluorosulfonyl-benzoate | n/a | |
| 23 | P11362_ACP | ACP | DB03909 | 91532 | CHEMBL133463 | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | n/a | |
| 24 | P11362_ACT | ACT | DB14511 | 175 | n/a | ACETATE ION | n/a | |
| 25 | P11362_AXU | AXU | n/a | 132185442 | CHEMBL4586512 | 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{H}-pyrazolo[3,4-d]pyridazin-7-one | n/a | |
| 26 | P11362_C4F | C4F | DB07525 | n/a | CHEMBL1231606 | 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine | inhibitor | IC50(nM) = 1690.0 |
| 27 | P11362_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 28 | P11362_CU | CU | n/a | 27099 | n/a | COPPER (II) ION | n/a | |
| 29 | P11362_DVT | DVT | n/a | n/a | n/a | DECAVANADATE | n/a | |
| 30 | P11362_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 31 | P11362_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 32 | P11362_GQL | GQL | DB07840 | n/a | n/a | (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol | n/a | |
| 33 | P11362_JVT | JVT | n/a | 60143238 | n/a | N-[4-(4-methylpiperazin-1-yl)phenyl]-1H-indazole-3-carboxamide | n/a | |
| 34 | P11362_LEV | LEV | DB09078 | 9823820 | CHEMBL1289601 | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | inhibitor | |
| 35 | P11362_LWJ | LWJ | DB12903 | 66555680 | CHEMBL3907479 | [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone | inhibitor | |
| 36 | P11362_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 37 | P11362_MK9 | MK9 | n/a | 53348188 | CHEMBL2216830 | N-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)prop-2-enamide | n/a | |
| 38 | P11362_O1Y | O1Y | n/a | 122604389 | n/a | N-{3-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-1-(2-hydroxyethyl)-1H-pyrazol-4-yl}prop-2-enamide | n/a | |
| 39 | P11362_O21 | O21 | n/a | 118029140 | CHEMBL3980461 | N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl][3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide | n/a | |
| 40 | P11362_PD1 | PD1 | n/a | 1401 | CHEMBL189584 | 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA | n/a | |
| 41 | P11362_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 42 | P11362_PGE | PGE | DB02327 | 8172 | CHEMBL1235259 | TRIETHYLENE GLYCOL | n/a | |
| 43 | P11362_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 44 | P11362_PPI | PPI | DB03766 | 1032 | CHEMBL14021 | PROPANOIC ACID | n/a | |
| 45 | P11362_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 46 | P11362_TZ0 | TZ0 | DB15149 | 71621331 | CHEMBL3701238 | 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | inhibitor | |
| 47 | P11362_VM1 | VM1 | n/a | 2776322 | n/a | 5-(2-thienyl)nicotinic acid | n/a | |
| 48 | P11362_WP1 | WP1 | n/a | 24229803 | n/a | 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide | n/a | |
| 49 | P11362_XL6 | XL6 | n/a | 138454915 | n/a | N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | n/a | |
| 50 | P11362_XOJ | XOJ | n/a | 91826045 | n/a | 1-tert-butyl-3-[2-[3-(diethylamino)propylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea | n/a | |
| 51 | P11362_YY4 | YY4 | n/a | 135316977 | n/a | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | n/a | |
| 52 | P11362_YY5 | YY5 | n/a | 135316972 | n/a | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | n/a | |
| 53 | P11362_YY6 | YY6 | n/a | 135317962 | n/a | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | n/a | |
| 54 | P11362_YY7 | YY7 | n/a | 135317507 | CHEMBL4061908 | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | n/a | |
| 55 | P11362_YY9 | YY9 | n/a | 135317287 | n/a | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | n/a | |
| 56 | P11362_SU1 | SU1 | DB08577 | 5289418 | CHEMBL89363 | 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE | n/a | IC50(nM) = 30.0 |
| 57 | P11362_SU2 | SU2 | DB02058 | 1633 | n/a | 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE | n/a | |
| 58 | P11362_BAX | BAX | DB00398 | 216239 | CHEMBL1336 | Sorafenib | inhibitor | IC50(nM) = 4.6 Kd(nM) = 2500.0 |
| 59 | P11362_DB08896 | n/a | DB08896 | n/a | n/a | Regorafenib | inhibitor | IC50(nM) = 1.5 |
| 60 | P11362_0LI | 0LI | DB08901 | 24826799 | CHEMBL1171837 | Ponatinib | inhibitor | IC50(nM) = 0.7 |
| 61 | P11362_XIN | XIN | DB09079 | 9809715 | CHEMBL502835 | Nintedanib | inhibitor | |
| 62 | P11362_AV9 | AV9 | DB11800 | 9911830 | CHEMBL1289494 | Tivozanib | inhibitor | |
| 63 | P11362_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 64 | P11362_DB15685 | n/a | DB15685 | n/a | n/a | Selpercatinib | inhibitor | |
| 65 | P11362_Q4J | Q4J | DB15822 | n/a | CHEMBL4297597 | Pralsetinib | inhibitor |