Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
P14416 DRD2_HUMAN
Gene name: DRD2
Protein name: D(2) dopamine receptor

List of molecules and drugs that interact with protein P14416

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 P14416_8NU 8NU DB00734 5073 CHEMBL85 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one antagonist Ki(nM) = 0.3
IC50(nM) = 3.6
2 P14416_GMJ GMJ DB00502 3559 CHEMBL54 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one antagonist Ki(nM) = 0.12
IC50(nM) = 0.16
Kd(nM) = 0.489779
3 P14416_OLA OLA n/a 445639 CHEMBL8659 OLEIC ACID n/a
4 P14416_PEG PEG n/a 8117 CHEMBL1235226 DI(HYDROXYETHYL)ETHER n/a
5 P14416_SIP SIP DB17056 5265 CHEMBL267930 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one antagonist
6 P14416_DB00182 n/a DB00182 n/a n/a Amphetamine binder Ki(nM) = 10000.0
7 P14416_DB00246 n/a DB00246 n/a n/a Ziprasidone antagonist Ki(nM) = 0.8
IC50(nM) = 5.0
8 P14416_DB00248 n/a DB00248 n/a n/a Cabergoline agonist
9 P14416_DB00268 n/a DB00268 n/a n/a Ropinirole agonist Ki(nM) = 7.2
EC50(nM) = 30.0
10 P14416_2GM 2GM DB00320 10531 CHEMBL1732 Dihydroergotamine agonist
11 P14416_DB00334 n/a DB00334 n/a n/a Olanzapine antagonist Ki(nM) = 2.1
IC50(nM) = 10.0
12 P14416_DB00363 n/a DB00363 n/a n/a Clozapine antagonist Ki(nM) = 6.87
IC50(nM) = 9.0
13 P14416_DB00372 n/a DB00372 n/a n/a Thiethylperazine antagonist
14 P14416_DB00391 n/a DB00391 n/a n/a Sulpiride antagonist Ki(nM) = 4.2
IC50(nM) = 10.28
15 P14416_DB00408 n/a DB00408 n/a n/a Loxapine antagonist Ki(nM) = 5.2
IC50(nM) = 54.0
16 P14416_DB00409 n/a DB00409 n/a n/a Remoxipride antagonist Ki(nM) = 16.0
IC50(nM) = 1.2
17 P14416_G6L G6L DB00413 119570 CHEMBL301265 Pramipexole agonist Ki(nM) = 3.9
IC50(nM) = 10000.0
Kd(nM) = 0.0149
EC50(nM) = 5.0
18 P14416_P2Z P2Z DB00420 4926 CHEMBL564 Promazine antagonist Ki(nM) = 160.0
19 P14416_P77 P77 DB00433 4917 CHEMBL728 Prochlorperazine antagonist Ki(nM) = 0.2
20 P14416_USS USS DB00450 3168 CHEMBL1108 Droperidol antagonist Ki(nM) = 0.25
21 P14416_IXX IXX DB00458 3696 CHEMBL11 Imipramine binder Ki(nM) = 620.0
IC50(nM) = 410.0
22 P14416_Z80 Z80 DB00477 2726 CHEMBL71 Chlorpromazine antagonist Ki(nM) = 0.66
IC50(nM) = 1.0
23 P14416_DB00490 n/a DB00490 n/a n/a Buspirone antagonist Ki(nM) = 13.0
24 P14416_DB00508 n/a DB00508 n/a n/a Triflupromazine antagonist Ki(nM) = 2.8
25 P14416_21B 21B DB00540 4543 CHEMBL445 Nortriptyline antagonist Ki(nM) = 2570.0
26 P14416_DB00543 n/a DB00543 n/a n/a Amoxapine antagonist Ki(nM) = 3.6
27 P14416_DB00555 n/a DB00555 n/a n/a Lamotrigine agonist
28 P14416_N90 N90 DB00568 1547484 CHEMBL43064 Cinnarizine other/unknown
29 P14416_H8G H8G DB00589 28864 CHEMBL157138 Lisuride agonist Ki(nM) = 0.34
30 P14416_DB00623 n/a DB00623 n/a n/a Fluphenazine antagonist Ki(nM) = 0.2
31 P14416_DB00679 n/a DB00679 n/a n/a Thioridazine antagonist Ki(nM) = 0.4
32 P14416_ERM ERM DB00696 8223 CHEMBL442 Ergotamine agonist
33 P14416_OR9 OR9 DB00714 6005 CHEMBL53 Apomorphine agonist Ki(nM) = 0.62
IC50(nM) = 4.2
Kd(nM) = 0.66
EC50(nM) = 1.6
34 P14416_8PR 8PR DB00715 43815 CHEMBL490 Paroxetine other/unknown Ki(nM) = 10000.0
35 P14416_DB00726 n/a DB00726 n/a n/a Trimipramine other/unknown
36 P14416_DB00734 n/a DB00734 n/a n/a Risperidone antagonist Ki(nM) = 0.3
IC50(nM) = 3.6
37 P14416_DB00777 n/a DB00777 n/a n/a Propiomazine antagonist
38 P14416_DB00805 n/a DB00805 n/a n/a Minaprine agonist
39 P14416_TFP TFP DB00831 5566 CHEMBL422 Trifluoperazine antagonist Ki(nM) = 0.96
40 P14416_DB00850 n/a DB00850 n/a n/a Perphenazine antagonist Ki(nM) = 0.16
IC50(nM) = 0.3
41 P14416_DB00875 n/a DB00875 n/a n/a Flupentixol antagonist
42 P14416_DB00915 n/a DB00915 n/a n/a Amantadine agonist
43 P14416_DB00933 n/a DB00933 n/a n/a Mesoridazine antagonist Ki(nM) = 4.3
44 P14416_DB00934 n/a DB00934 n/a n/a Maprotiline binder
45 P14416_LDP LDP DB00988 681 CHEMBL59 Dopamine agonist Ki(nM) = 1.9
IC50(nM) = 0.0
EC50(nM) = 0.631
46 P14416_DB01038 n/a DB01038 n/a n/a Carphenazine antagonist
47 P14416_DB01043 n/a DB01043 n/a n/a Memantine antagonist
48 P14416_DB01063 n/a DB01063 n/a n/a Acetophenazine antagonist
49 P14416_DB01069 n/a DB01069 n/a n/a Promethazine antagonist IC50(nM) = 100.0
50 P14416_1II 1II DB01100 16362 CHEMBL1423 Pimozide antagonist Ki(nM) = 0.39
51 P14416_DSM DSM DB01151 2995 CHEMBL72 Desipramine binder Ki(nM) = 1561.0
52 P14416_68P 68P DB01175 146570 CHEMBL1508 Escitalopram inhibitor
53 P14416_DB01184 n/a DB01184 n/a n/a Domperidone antagonist Ki(nM) = 0.58
IC50(nM) = 3.4
54 P14416_DB01186 n/a DB01186 n/a n/a Pergolide agonist Ki(nM) = 0.62
55 P14416_08Y 08Y DB01200 31101 CHEMBL493 Bromocriptine agonist Ki(nM) = 0.62
56 P14416_DB01221 n/a DB01221 n/a n/a Ketamine agonist
57 P14416_DB01224 n/a DB01224 n/a n/a Quetiapine antagonist Ki(nM) = 16.0
58 P14416_DB01233 n/a DB01233 n/a n/a Metoclopramide antagonist Ki(nM) = 64.0
IC50(nM) = 70.0
59 P14416_DAH DAH DB01235 6047;6971033; CHEMBL1009 Levodopa agonist
60 P14416_9SC 9SC DB01238 60795 CHEMBL1112 Aripiprazole antagonist Ki(nM) = 0.2
IC50(nM) = 7.6
EC50(nM) = 1.0
61 P14416_DB01239 n/a DB01239 n/a n/a Chlorprothixene antagonist
62 P14416_DB01267 n/a DB01267 n/a n/a Paliperidone antagonist Ki(nM) = 1.0
IC50(nM) = 8.3
63 P14416_DB01392 n/a DB01392 n/a n/a Yohimbine antagonist Ki(nM) = 280.0
64 P14416_DB01403 n/a DB01403 n/a n/a Methotrimeprazine antagonist
65 P14416_DB01425 n/a DB01425 n/a n/a Alizapride antagonist
66 P14416_DB01549 n/a DB01549 n/a n/a Rolicyclidine inhibitor
67 P14416_PMZ PMZ DB01614 6077 CHEMBL39560 Acepromazine antagonist
68 P14416_DB01618 n/a DB01618 n/a n/a Molindone antagonist Ki(nM) = 3.8
69 P14416_DB01621 n/a DB01621 n/a n/a Pipotiazine antagonist Ki(nM) = 0.2
70 P14416_DB01622 n/a DB01622 n/a n/a Thioproperazine antagonist Ki(nM) = 0.45
71 P14416_DB01623 n/a DB01623 n/a n/a Thiothixene antagonist Ki(nM) = 0.12
72 P14416_DB01624 n/a DB01624 n/a n/a Zuclopenthixol antagonist
73 P14416_4MP 4MP DB04599 2196 CHEMBL36994 Aniracetam inhibitor
74 P14416_DB04842 n/a DB04842 n/a n/a Fluspirilene antagonist Ki(nM) = 0.2
75 P14416_DB04844 n/a DB04844 n/a n/a Tetrabenazine inhibitor
76 P14416_DB04857 n/a DB04857 n/a n/a Brasofensine n/a
77 P14416_DB04888 n/a DB04888 n/a n/a Bifeprunox modulator Ki(nM) = 0.04
IC50(nM) = 2.9
78 P14416_DB04889 n/a DB04889 n/a n/a Bicifadine n/a
79 P14416_DB04924 n/a DB04924 n/a n/a Itopride n/a
80 P14416_DB04946 n/a DB04946 n/a n/a Iloperidone antagonist Ki(nM) = 0.35
IC50(nM) = 110.0
81 P14416_DB05271 n/a DB05271 n/a n/a Rotigotine agonist
82 P14416_DB05766 n/a DB05766 n/a n/a Norclozapine n/a
83 P14416_DB05964 n/a DB05964 n/a n/a Amitifadine n/a
84 P14416_7RU 7RU DB06016 n/a CHEMBL2028019 Cariprazine partial agonist Ki(nM) = 0.41
IC50(nM) = 1.7
EC50(nM) = 0.18
85 P14416_92S 92S DB06077 21302490 CHEMBL3306803 Lumateperone partial agonist
86 P14416_DB06144 n/a DB06144 n/a n/a Sertindole antagonist Ki(nM) = 0.38
87 P14416_DB06148 n/a DB06148 n/a n/a Mianserin antagonist
88 P14416_DB06216 n/a DB06216 n/a n/a Asenapine antagonist Ki(nM) = 1.87
89 P14416_DB06229 n/a DB06229 n/a n/a Ocaperidone modulator
90 P14416_DB06288 n/a DB06288 n/a n/a Amisulpride antagonist Ki(nM) = 1.3
IC50(nM) = 1.5
91 P14416_DB06454 n/a DB06454 n/a n/a Sarizotan partial agonist
92 P14416_DB06477 n/a DB06477 n/a n/a Sumanirole agonist
93 P14416_DB08815 n/a DB08815 n/a n/a Lurasidone antagonist Ki(nM) = 1.2
94 P14416_DB08922 n/a DB08922 n/a n/a Perospirone antagonist
95 P14416_DB09018 n/a DB09018 n/a n/a Bromopride antagonist
96 P14416_DB09097 n/a DB09097 n/a n/a Quinagolide agonist
97 P14416_DB09128 n/a DB09128 n/a n/a Brexpiprazole partial agonist Ki(nM) = 0.3
EC50(nM) = 6.3
98 P14416_DB09194 n/a DB09194 n/a n/a Etoperidone antagonist Ki(nM) = 2300.0
99 P14416_DB09207 n/a DB09207 n/a n/a AS-8112 antagonist
100 P14416_DB09223 n/a DB09223 n/a n/a Blonanserin antagonist Ki(nM) = 0.14
101 P14416_DB09224 n/a DB09224 n/a n/a Melperone antagonist Ki(nM) = 3.6
102 P14416_ZOT ZOT DB09225 5736 CHEMBL285802 Zotepine antagonist Ki(nM) = 5.4
103 P14416_DB09286 n/a DB09286 n/a n/a Pipamperone antagonist Ki(nM) = 110.0
104 P14416_DB11274 n/a DB11274 n/a n/a Dihydro-alpha-ergocryptine agonist
105 P14416_DB12061 n/a DB12061 n/a n/a Pardoprunox agonist
106 P14416_DB12093 n/a DB12093 n/a n/a Tetrahydropalmatine antagonist
107 P14416_DB12478 n/a DB12478 n/a n/a Piribedil agonist
108 P14416_DB12518 n/a DB12518 n/a n/a Raclopride antagonist
109 P14416_DB12579 n/a DB12579 n/a n/a JNJ-37822681 antagonist
110 P14416_DB13025 n/a DB13025 n/a n/a Tiapride blocker
111 P14416_DB14185 n/a DB14185 n/a n/a Aripiprazole lauroxil partial agonist